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Biomedical subjects

K Ono

Publications and source records attributed to K Ono.

At least 901 records · Page 50Linked to original sources
PubMed1990

[Clinical, cytogenetic and immunological studies of 2 cases with B-cell acute lymphocytic leukemia. Comparison between B-ALL and Burkitt's lymphoma reported in Japan].

Two patients with acute lymphocytic leukemia of B-cell phenotype (B-ALL) are described. They were 77-year-old female and 34-year-old male. One patient presented with marked splenomegaly, and the other with rupture of spleen on admission. Leukemic morphology revealed a typical L3 profile by FAB classification system in both cases. Immunologic analysis showed the presence of surface immunoglobulins in both cases, and one phenotype was IgM kappa, whereas the other was IgG kappa. Cytogenetic study revealed the typical translocations (8; 14) in both cases. Following chemotherapy, complete remission was achieved in one case, but the other died 36 days after admission. Including our two cases, we studied 12 cases of B-ALL and 77 cases of Burkitt's lymphoma reported in Japan, investigating the clinical prognosis as well as the biological features. We concluded that there are no significant difference of survival between B-ALL and Burkitt's lymphoma. We estimated it is due to oncogenesis from the same original cell in despite of the difference in main tumor site between two diseases.

Adult↗
PubMed1990

[A solitary extramedullary plasmacytoma of the nasopharynx].

A 72-year-old male, complaining of epistaxis, was referred to our hospital where a physical exam revealed a tumorous mass in the nasopharynx. A subsequent immunohistopathological investigation found that the tumor mass was a plasmacytoma with IgG and a lambda chain. Electrophoresis of a serum sample revealed a normal value and there was no signs indicating a multiple myeloma on x-ray surveys of the skeleton, or from bone marrow aspiration or scintigraphy. Thus the diagnosis was an extramedullary plasmacytoma and the patient received a combined treatment of chemotherapy, radiotherapy, and surgery. Since surgery, the patient has had neither a recurrence or a metastasis of the tumor for four years and three months.

Aged↗
PubMed1990

[Effect of induced hypotension on arterial blood-gases].

Arterial blood-gases were evaluated before, during and after the vasodilator induced hypotension in patients undergoing mastectomy. Forty-two patients studied were anesthetized with halothane and nitrous oxide in oxygen. They were divided into following four groups according to vasodilators used: trimetaphan (TMP), nitroglycerin (TNG), adenosine triphosphate (ATP), and prostaglandin E1 (PGE1). Significant reduction in PaO2 was observed during induced hypotension in all groups. However, there was no difference in the degree of PaO2 decrease among four groups. A small but significant increase in PaCO2 and a decrease in pH were observed during and/or after hypotension with TNG and PGE1. These findings suggest that induced hypotension may impair the pulmonary gas exchange by decreased cardiac output and/or change in ventilation-perfusion ratio regardless of vasodilators used. Therefore, continuous arterial blood-gas monitoring should be desirable under these conditions.

Adenosine Triphosphate↗
PubMed1990

A case of acinic cell carcinoma of the palate.

A case of acinic cell carcinoma in the palate is reported here. Acinic cell carcinoma is a relatively rare type of adenocarcinoma of salivary gland origin. The patient, an 83-year-old male, complained of swelling in the palate. A red soft mass approximately 8 mm in diameter was noticed in the right maxillary first molar region. Histopathological diagnosis of the surgically removed specimen was acinic cell carcinoma. The tumor had invaded the maxilla. Surgical excision with a border of normal tissue seemed to be an effective form of treatment. The patient exhibited good clinical recovery without recurrence or metastasis.

Aged↗
PubMed1990

[Mitogenic activity of lipopolysaccharide from Bacteroides intermedius against C3H/HeJ mice spleen cells].

Bacteroides intermedius is one of the periodontal disease generative bacteria. Lipopolysaccharide preparation obtained from B. intermedius ATCC 25611 and ATCC 33563 strains was investigated as to Limulus activity observed with Pyrodic (endotoxin specific) reagent, and mitogenic activity in both normal and tolerant mice induced by Escherichia coli. Limulus activities of all LPS's were nearly similar to that of E. coli. LPS's preparation from B. intermedius were found to be strongly mitogenic for C3H/HeN mice spleen cells, whereas no LPS preparations were mitogenic for thymocytes of BALB/c mice. LPS-nonresponsive C3H/HeJ mice spleen cells were found to good mitogenic responses to LPS's from B. intermedius, as well as LPS from B. gingivalis 381 strain. Polymyxin B had remarkable inhibitory effect on the mitogenicity of LPS's from B. intermedius for C3H/HeN and C3H/HeJ mice spleen cells, also that activity of B. gingivalis LPS was inhibited by polymyxin B. The mitogenicity of the LPS from B. intermedius, as measured in C3H/HeJ mice spleen cells, was considerably resistant to the proteolytic effects of proteinase K.

Animals↗
PubMed1990

Pathohistological study on changes observed in the temporomandibular joint after experimental mutilation and shortening of the mandibular process with special reference to the changes under abnormal mandibular movement.

Abnormal mandibular movement continues to occur when fracture of the mandibular process has resulted in abnormal occlusion or abnormal mandibular movement. However, what changes might occur in the temporomandibular joint have not yet been fully clarified. In the present study, a fracture of the condylar process was experimentally induced in rats, and the resulting bone ends were wired in place. That is to say, the resulting displacement was fixed permanently. Histological studies were made on the changes of the temporomandibular joint at the postoperative third month in those rats which demonstrated abnormal occlusion and abnormal mandibular movement. Lack of uniformity of the fibrous layer and a shallowing of the mandibular fossa; proliferation of the fibrous connective tissue and reduction in size of the superior and inferior articular cavity; tylosis and irregularity in the articular disc; deformation and tylosis of the fibrous layer of the articular cartilage, tendency of the layer structure in the articular cartilage to disappear, and some effect on cartilaginous ossification in the condyle; flattening of the condyle and thinning of the layer structure in the condylar articular cartilage in the unaffected side of the mandibular joint. These changes were observed to be more marked as the displacement and occlusal abnormality of the mandible intensified, showing no morphological adaptation of the temporomandibular joint.

Animals↗
PubMed1990

An experimental study on the healing process after excision of the articular disc of the mandible--effect of short-term intermaxillary fixation.

In the present study, intermaxillary fixation for a period of 1 or 2 weeks after excision of the articular disc was administered to maturing rats. After removal of the fixation, the animals were allowed unrestricted mandibular movement. Histological observations were made at the postoperative 3rd month in those rats which demonstrated normal occlusion. As a result, it was found that the normal articular disc did not regenerate. However, in the articular cavity, both connective tissue and articular disc-like structures were found. The major changes in the mandibular fossa were tylosis of the outer fibrous layer of the fossa and an accompanying shallowing tendency. The major changes in the condyle were tylosis and morphological deformation of the fibrous layer of the parietal region. The deformation was mainly manifested by a fan-shaped hypertrophy. In the cases in which neither connective tissue nor articular disc-like structures were present in the articular cavity, changes in the mandibular fossa and condyle were remarkable. The appearance of the articular disc-like structure was more frequent in cases with 2-week intermaxillary fixation than in those with 1-week fixation.

Animals↗
PubMed1990

[Granular lymphocyte proliferative disorder with penis cancer].

A case of granular lymphocyte proliferative disorder with squamous cell carcinoma of penis is described. A 77-year-old Japanese male was admitted to our hospital in March, 1989 because of ulceration of penis and lymphocytosis. He had hepatomegaly and lymphadenopathy but not splenomegaly on physical examination. The WBC count was 10800/microliters with 83% of granular lymphocytes. Thrombocytopenia (32000/microliters) and mild anemia were also demonstrated. Bone marrow aspirate showed hypercellular marrow with 84% of granular lymphocytes. Proliferative granular lymphocytes were CD2+ CD3+ CD4- CD8- CDw29+ and exhibited ADCC activity but not NK activity. On March 15, amputation of penis was performed. But his lymphocytosis didn't change and thrombocytopenia increased. Thus we considered his granular lymphocytosis was neoplastic rather than reactive. Our case seemed to be rare and was compared with previous reports.

Aged↗
PubMed1990

[Malignant lymphoma with acute renal failure and nephrotic syndrome].

A case of non-Hodgkin's lymphoma with nephrotic syndrome and acute renal failure is described. A 60-year-old Japanese male was admitted to our hospital in November, 1988, because of lymphadenopathy, fever, night sweat, weight loss. On physical examination, lymphadenopathy was present in both cervical, submandibular, supraclavicular, axillary and inguinal regions. The leukocyte count was 9,700/microliters with 85% neutrophils and 2% atypical lymphocytes. Renal function was normal. Lymph node biopsy showed non-Hodgkin's lymphoma of diffuse, large cell type. Immunohistologic examination showed T cell type. A few days later, he fell into acute renal failure. After systemic chemotherapy, he showed prompt improvement in renal function. Echo and computerized tomography (CT) of abdomen revealed no compression of the ureters and bladder. Renal biopsy findings suggested mesangium proliferative glomerulonephritis without invasion of tumor cells. Our case seemed to be rare and was compared with previous reports.

Acute Kidney Injury↗
PubMed1990

[Oral galactose tolerance test in the study of glucose metabolism disorders in patients with liver disease].

Patients with chronic liver disease (CLD) may show an abnormal glucose tolerance test (GTT). On the other hand, it is debated whether diabetics may undergo abnormalities of liver function. The aim of our study was to see whether galactose tolerance test (GaTT) is a suitable complementary diagnostic tool in defining the glucose metabolism abnormalities characteristic of the two above mentioned clinical entities. Thirty-one patients with CLD, 16 adult diabetics and 12 healthy volunteers were considered. GTT with radioimmunoassay of plasmatic insulin (IRI) and oral GaTT were performed. CLD patients were divided into two groups: with IRI/glycemia greater than 0.4 or less than 0.4. On GaTT, galactosemia was significantly raised in CLD compared to diabetics and control. Further, a statistically significant difference was shown in the glycemic variations during GaTT between diabetics and both CLD groups. A significantly inverse ratio galactosemia/glycemia occurred during GaTT and showed a different pattern between diabetics and CLD patients with impaired insulin secretion. A careful study of galactosemia and glycemia variations during GaTT reliably defines the different patterns of glucose metabolism derangement in CLD with abnormal GTT and in diabetics.

Blood Glucose↗
PubMed1990

Frequency of micronuclei in hepatocytes following X and fast-neutron irradiations--an analysis by a linear-quadratic model.

The usefulness of the micronucleus assay for investigating the radiation response of hepatocytes was examined. The frequency was defined as the ratio of the total number of micronuclei to the number of hepatocytes examined. The dose-response curves were curvilinear after X rays and linear after neutrons. These dose-response curves were analyzed by a linear-quadratic model, frequency = aD + bD2 + c. The a/b ratio was 3.03 +/- 1.26 Gy following X irradiation. This value is within the range of the alpha/beta ratios reported by others using the clonogenic assay of hepatocytes. While the a/b value for neutrons was 24.3 +/- 11.7 Gy, the maximum relative biological effectiveness of neutrons was 6.30 +/- 2.53. Since the micronucleus assay is simple and rapid, it may be a good tool for evaluating the radiation response of hepatocytes in vivo.

Animals↗
PubMed1990

[Hypoxic cell radiosensitizer present status and problems from viewpoint of clinical radiotherapy].

The results of clinical trials of hypoxic cell radiosensitizers were reviewed in order to clarify the present status and problems in this field. Most trials failed to show an effectiveness of the combination, however, some ENT tumors and bladder cancers were improved in local tumor responses and survivals. A selection of the patients suitable for the combination and development of simple method for the selection are indispensable. SERs necessary for clinical radiotherapy are considered to be larger than 1.2 at 2 Gy fraction level. Present hypoxic cell radiosensitizers have no significant effects on alpha values. Since radiation responses at low radiation dose ranges are dominated by alpha values, the chemicals having an effects on alpha values have to be developed.

Cell Hypoxia↗
PubMed1990

Clinical and EEG studies on complex partial seizure in children.

In 18 (40%) of 45 patients with CPS, paroxysmal discharges were hard to be found on their interictal EEG examinations. These patients were, however, not different from the other 27 patients with paroxysmal discharges on EEG as for the onset, prognosis for attack, complication of generalized tonic-clonic seizure and febrile convulsion, family history and adaptation to society.

Adolescent↗
PubMed1990

Treatment of murine SCC VII tumors with localized hyperthermia and temperature-sensitive liposomes containing cisplatin.

The release of cisplatin (CDDP) encapsulated in temperature-sensitive unilamellar liposomes to murine SCC VII carcinoma by localized hyperthermia and the effects of the treatment on tumor growth were studied. A transition temperature of the temperature-sensitive liposomes containing cisplatin (LIP-CDDP) was 41 degrees C. Twenty-four hours after injection of LIP-CDDP, the heated tumors (42 degrees C, 60 min) contained 3.3 times more CDDP than the unheated tumors receiving free CDDP. Although the uptake of liposome-associated CDDP by liver was approximately threefold greater at 1.5 h after injection than uptake of free CDDP, it decreased about 50% over a 24-h period. No difference in uptake of the two forms of CDDP by kidney was observed. The combination of LIP-CDDP and localized heating at 42 or 43 degrees C was more effective relative to the amount of CDDP in delaying tumor growth than that of free CDDP and hyperthermia. Treatment with LIP-CDDP plus local heating resulted in a dose-modifying factor of 5.3 when compared with free CDDP and no hyperthermia. The dose-modifying factor was 2.8 when treatment with LIP-CDDP and heat was compared with treatment with free CDDP and heat. Thus CDDP could be released selectively from the temperature-sensitive liposomes by heat and resulted in both a greater uptake of the drug and a delay in tumor growth.

Animals↗
PubMed1990

Structure of chicken aldolase C mRNA and its expression in the liver and brain during development.

Chicken aldolase B (liver-type) and C (brain-type) cDNAs were isolated and their nucleotide sequences determined. Southern blot analysis of chicken genomic DNA using the fragments of aldolase C cDNA suggested that the aldolase C gene is a single-copy gene. The quantification by Northern blot analysis of aldolase B and C mRNAs in the chicken liver and brain during development showed that in the liver, the B gene was progressively activated, while C gene expression was extinguished reciprocally. In the brain, the B gene was silent throughout the development, while the C gene was activated progressively, reaching a product level of more than 20-fold that of the 7-day-old embryo.

Amino Acid Sequence↗
PubMed1990

Brainstem afferents to the intralaminar nuclei of the cat thalamus studied by the horseradish peroxidase method.

Brainstem afferents to the intralaminar thalamic nuclei of the cat have been studied by retrograde axonal transport of horseradish peroxidase (HRP) or wheat germ agglutinin conjugated to HRP (WGA-HRP). Injections of HRP or WGA-HRP into the lateral central and paracentral nuclei led to labeling of cells in various diencephalic structures of the injected side. Some cells were labeled in the intralaminar and medial pulvinar nuclei. A large number of labeled cells were detected in the thalamic reticular and ventral lateral geniculate nuclei. The zona incerta and field of Forel contained a few labeled cells. Occasional labeled cells were seen in the dorsomedial, ventromedial, posterior and lateral hypothalamic nuclei. Labeling of cells in the more caudal brainstem structures was found bilaterally, mostly with ipsilateral predominance. Some labeled cells were detected in the pretectal nuclei, the periaductal gray and the pars reticulata of the substantia nigra as well. The nuclei of Darkschewitsch and Cajal contained occasional labeled cells. Numerous cells were labeled in the superior colliculus, mainly in layers 3 and 4. A number of labeled cells were distributed in almost the entire extent of the brainstem reticular formation. It should be mentioned that the gigantocellular reticular nucleus contained labeled cells bilaterally with contralateral predominance. Very few labeled cells were encountered in the ipsilateral dorsal tegmental and parabrachial nuclei. A few cells were labeled in the vestibular nuclei and nucleus prepositus hypoglossi bilaterally. Some labeled cells were detected mainly contralaterally in three cerebellar nuclei; the fastigial, the interposed and the dentate. Injections of WGA-HRP into the medial central nucleus showed a different pattern of labeling. It is noteworthy that no labeled cells were found in the dorsal thalamus, the hypothalamus (except for the lateral mamillary nucleus), the superior colliculus or the cerebellar nuclei.

Animals↗