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Biomedical subjects

K Ohmori

Publications and source records attributed to K Ohmori.

At least 397 records · Page 22Linked to original sources
PubMed1985

[Heterotopic gastric mucosa in the wall of the gallbladder: a case report and review of the literature].

A case of heterotopic gastric mucosa (pyloric gland) in the wall of the gallbladder was reported. A 58 year-old woman was admitted with a history of sudden attack of hypochondralgia radiating to the back, but she had no fever and jaundice. Ultrasonography demonstrated high echo at the neck and body of the gallbladder. Cholecystectomy was performed with a diagnosis of the gallbladder tumor containing gall stone. The surgical specimen revealed a 15 X 14 X 8mm subserosal tumor in the body and chronic cholecystitis, but showed no metaplastic differentiation in the mucosa. The cause was considered to be congenital. Heterotopic tissue in the wall of the gallbladder was very rare. In the literature, there were 29 cases of gastric mucosa and 27 cases of pancreatic tissue. The mean age of incidence were 31.9 and 42.0 year-old, respectively. There is no sex difference. The lesion was located in the cystic duct and the neck of the gallbladder in half the patients. Cholelithiasis and/or cholecystitis was complicated in many cases, and it might be associated with heterotopic tissue whereas the etiology is unknown.

Choristoma↗
PubMed1984

[Chronic renal dysfunction in workers exposed to cadmium oxide fume. Medical examinations of welders using cadmium containing silver solder].

Workers, who had been exposed to cadmium oxide fume, i.e., engaged in welding work with cadmium containing silver solder in an automobile parts manufacturing factory, were examined in 1975. Twenty two male welders were 22 to 55 years old and exposed to cadmium for periods ranging from 7 months to 23 years. Excreted urinary cadmium levels varied from 5.7 micrograms to 184.9 micrograms per day, and these values were useful indices of most recent exposures in workshop environments. The examinees were divided into three groups according to excreted urinary cadmium levels: five of them in high, eleven in middle, and six in low group, respectively. Workers in high-excretion group complained of considerable subjective symptoms and their urinary protein showed a remarkable increase, compared to middle- and low-excretion groups, and the electrophoretic pattern of urinary proteins showed preponderance of globulins. Urinary calcium and beta 2-microglobulin in the high-excretion group showed a remarkable increase. In all examinees, urinary phosphate, calcium, and beta 2-microglobulin were significantly correlated with urinary excreted cadmium. Furthermore, in the high-excretion group showed a considerable increase of serum creatinine values and reduction of creatinine clearance, and percent tubular reabsorption of phosphate, calcium and beta 2-microglobulin decreased. In all examinees, creatinine clearance and percent tubular reabsorption of both phosphate and calcium were significantly negatively correlated with urinary cadmium excretion. Therefore, five high-excretion workers showed evidence of chronic renal tubular dysfunction and one of these was particularly recognized as having remarkable renal damage. The possibility to affirm the effects of exposure to cadmium was suggested on hematological findings related to anemia. Liver function abnormalities were not recognized. A slight reduction of the respiratory function was found in one worker of the high-excretion group, but radiological examination of chest showed no abnormalities in all examinees.

Adult↗
PubMed1984

[A case of localized lipomatosis in the pancreatic head presenting a lipoma-like appearance].

A 63-year-old woman with localized lipomatosis in the pancreatic head is reported. She was diagnosed to have a lipoma by clinical data including CT scanning. Histopathological examination of the extirpated mass revealed that the lesion was mostly composed of mature fatty tissue without any lobulation or encapsulation by connective tissue, there was a small amount of scattered pancreatic parenchyma at the peripheral and deeper parts of the mass. No Langerhans' islets were detected. Based on these findings, the lesion was diagnosed as localized lipomatosis in the pancreatic head.

Female↗
PubMed1983

Immunoregulatory T cell function in patients with primary biliary cirrhosis.

Both concanavalin A (Con A)-induced suppressor cell activity and autologous mixed lymphocyte reaction (AMLR) were significantly decreased in patients with primary biliary cirrhosis (PBC) in comparison with those of healthy subjects (p less than 0.001) and p less than 0.001, respectively). Factors inhibiting lymphocyte transformation by Con A and PHA were demonstrated in sera from a majority of the patients with PBC. In approximately half of these patients, some serum factor(s) also induced a decrease of Con A-induced suppressor cell function of lymphocytes from healthy subjects. These results suggest that patients with PBC have impaired immunoregulatory lymphocyte function which may be related to some factor(s) present in serum.

Adult↗
PubMed1983

[Pharmacological studies on oxatomide: (6) Effect on the peripheral organs].

The effects of oxatomide, an anti-allergic drug, on the cardiovascular, digestive and autonomic nervous systems were investigated, and the following results were obtained: Intravenous administration of oxatomide, at doses of 1 mg/kg or more, lowered arterial blood pressure, decreased heart rate, increased femoral blood flow, and depressed the gastrointestinal and uterine movement in anesthetized dogs, rabbits and rats. In in vitro experiments, oxatomide inhibited spontaneous movements of isolated rabbit ileum, isolated guinea pig atrium and isolated rat uterus at considerably high concentrations of 10(-6)M or more. The antagonistic activity of oxatomide for histamine in isolated guinea pig ileum and trachea was observed at concentrations of 3 X 10(-8)M or more. Oral administration of oxatomide, however, had no significant influence on the cardiovascular, digestive and autonomic nervous systems and urogenital organs, at doses up to 100 mg/kg. The antigenicity of oxatomide was studied with immunological procedures such as active anaphylactic shock, passive cutaneous anaphylaxis and passive hemagglutination test in guinea pigs, rats and mice. In these tests, neither anaphylactic shock nor allergic reaction was observed. From these results, it is suggested that oxatomide shows little effect on peripheral organs at a dose which elicits the anti-allergic actions and may have no antigenicity to experimental animals.

Animals↗
PubMed1983

[Pharmacological studies on oxatomide. (5). Effect on the central and peripheral nervous systems].

The effect of oxatomide, an antiallergic drug, on the central and peripheral nervous systems were investigated, and the following results were obtained: Oxatomide at oral doses of 30-100 mg/kg produced little or no effect on the spontaneous and cooperative movements in mice, hexobarbital-induced hypnosis in mice, body temperature in rats, and did not induce muscle relaxation, the analgesic effect, anticonvulsive effects and anti-physostigmine effect. Oxatomide at doses of 300 mg/kg or more produced sedation followed by an increase in the responses to stimuli in mice and rats. These behavioral changes diminished within 7-8 hours. Oxatomide (2 mg/kg, i.v.) changed the EEG to a slightly drowsy pattern in unanesthetized, unrestrained rabbits. Neither the EEG arousal responses evoked by auditory stimulation or electrical stimulation to the mesencephalic reticular formation, nor the limic afterdischarges induced by electrical stimulation to the hippocampus or amygdala were affected by oxatomide at any of the doses employed. Oxatomide had no effect on the spinal reflex in cats, conditioned behavior in rats or local anesthesia in guinea pigs. These results suggest that oxatomide shows little effect on the central and peripheral nervous systems at a dose sufficient to elicit the antiallergic actions.

Analgesics↗
PubMed1983

[Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators].

The effects of oxatomide, an anti-allergic drug, on the actions of chemical mediators were investigated in guinea pigs, rats and cats; and the following results were obtained: Studies on the guinea pig ileum revealed oxatomide to be a potent antagonist of histamine with a dual type of action, being competitive at low doses and noncompetitive at higher doses. Oxatomide at concentrations of 0.1 microM or higher inhibited the contractile responses evoked by crude SRS-A from sensitized guinea pig lung. Oxatomide (0.1 to 10 microM) did not inhibit the chronotropic effect of histamine in guinea pig atrium. In anaesthetized guinea pigs, serotonin-induced bronchoconstriction was antagonized by oxatomide (0.1 to 1 mg/kg, i.v.) as effectively as histamine-induced bronchoconstriction. However, oxatomide (up to 1 mg/kg, i.v.) did not inhibit acetylcholine-induced or arachidonic acid-induced bronchoconstriction. Oxatomide given orally in the range of 5 to 30 mg/kg markedly inhibited the increased vascular permeability by histamine, serotonin, and bradykinin in rats. Oxatomide at doses of 0.03 mg/kg (i.v.) or higher also prevented the contraction of the nictitating membrane induced by serotonin in cats. Oxatomide (0.3 microM and 1 microM) inhibited competitively the calcium-induced contracture of fully-depolarized taenia coli of guinea pigs. From these results, oxatomide appears to have potent antagonistic activities on the actions of various chemical mediators. These properties of oxatomide may contribute to its anti-allergic activity.

Acetylcholine↗
PubMed1983

[Clinical evaluation of micronomicin for the treatment of postoperative infections in cancer patients].

Micronomicin (MCR, Sagamicin), a new derivative of aminoglycoside, was used in 9 patients with postoperative infection mainly caused by Gram-negative bacilli. A dose of 60-120 mg was intramuscularly administered continuously twice a day for 3-21 days. The therapeutic results were excellent in 2, good in 3, fair in 1 and poor in 2 cases. The assessment was impossible in 1 patient. The effective rate was 62.5%. No side effects were encountered in any cases.

Adult↗