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Biomedical subjects

K Miyauchi

Publications and source records attributed to K Miyauchi.

At least 91 records · Page 5Linked to original sources
PubMed1990

Serum immunoreactive pancreatic phospholipase A2 in patients with various malignant tumors.

The high incidence (40.6%) of elevated serum pancreatic phospholipase A2 (PLA2) was demonstrated in patients with various malignancies. Serum PLA2 was significantly increased in cancer patients compared with healthy sex- and age-matched blood donors (358.4 +/- 168.0 vs. 241.7 +/- 69.0 ng/dl; p less than 0.01). No correlation was observed between serum PLA2 and carcinoembryonic antigen (CEA) in these patients. Although patients with advanced and distantly metastatic cancer of the liver, gallbladder and pancreas showed higher PLA2 levels in serum than those with early cancer, patients with other cancers showed no correlation between serum PLA2 and clinical stage. A combined assay of PLA2 and CEA increased the sensitivity of detection of cancers to 60.8%.

Amylases↗
PubMed1990

Suppression of exercise-induced ventricular arrhythmias by propranolol and diltiazem in a woman without organic heart disease--a case report.

A thirty-five-year-old woman without organic heart disease who has exercise-induced ventricular arrhythmias suppressed by propranolol and diltiazem is reported. Treadmill exercise provoked reproducibly nonsustained ventricular tachycardia (NSVT) and salvos of ventricular premature contraction (VPC). QRS morphology of these ventricular arrhythmias showed left bundle branch block pattern and right axis deviation. Oral propranolol (20 mg) and diltiazem (90 mg) prevented exercise provocation of NSVT and VPC. However, oral mexiletine (200 mg) and procainamide (500 mg) could not prevent exercise provocation of these ventricular arrhythmias. No ventricular arrhythmias could be induced by any form of ventricular extrastimulations. Right ventricular pacing at a rate of 210 beats/minute provoked NSVT of which the QRS morphology was similar to that of exercise-induced NSVT. Triggered activity may be a possible electrophysiologic mechanism for exercise-induced ventricular arrhythmias in this patient, although other mechanisms such as reentry and enhanced automaticity could not be completely excluded.

Adult↗
PubMed1990

[A long-term follow-up study of intra-arterial infusion chemotherapy in locally advanced breast cancer].

Long-term follow-up results were reported for 61 patients with locally advanced breast cancer treated by intraarterial infusion chemotherapy (IA), compared with those for 96 patients who received no such treatment. The results were as follows. (1) The response rate of the primary lesions to IA was 53.6%, and the post-surgical survival of responders (CR, PR) was significantly better than those of non-responders (NC). (2) Excellent loco-regional control was also achieved in the IA-group. The local recurrence rate was only 16.2%. (3) However, there was no difference between survival rates of each group. The author confirmed that IA was an effective initial treatment for locally advanced breast cancer in terms of loco-regional control, but definite conclusions can be made only after randomized study.

Antineoplastic Agents↗
PubMed1989

Isolation and characterization of a new 36-kDa microfibril-associated glycoprotein from porcine aorta.

A new connective tissue protein of 36 kDa has been purified from porcine aorta. The biochemical and immunological properties of the protein are distinct from those of microfibril-associated proteins reported previously such as lysyl oxidase, 31-kDa microfibril-associated glycoprotein, and fibrillin. It could bind to concanavalin A-Sepharose and gelatin-Sepharose. The protein contained the sequence Arg-Gly-Asp-Ala in the amino-terminal region, which is the site for the association with cell and extracellular matrix. Using specific antibody raised to the protein, we demonstrated its restricted localization in aorta adventitia. Immunoelectron microscopy specified its location to a class of extracellular structural elements described as elastin-microfibrils.

Amino Acid Sequence↗
PubMed1989

Stress lymphocytes and the dexamethasone suppression test in major depressive disorders.

The Dexamethasone Suppression Test (DST) was administered to 12 patients with major depression and 4 normal controls. Peripheral blood smears were collected before and after the DST, and atypical lymphocytes were counted. Six patients who were nonsuppressors on the DST had a high percentage of so-called stress lymphocytes (Downey type II atypical lymphocytes). Five of six subjects with normal suppressor responses had low stress lymphocyte counts or no such cells (p less than 0.01). The findings suggest that the stress lymphocyte response might be related to nonsuppression on the DST in major depression.

Adolescent↗
PubMed1989

Enzyme immunoassay of estrogen and progesterone receptors in drill biopsy specimens from breast cancer.

We have applied enzyme immunoassay (EIA) to the detection of estrogen and progesterone receptors (ER and PR, respectively) in small samples obtained by drill biopsy of primary breast cancers. Thirty patients with breast cancer underwent drill biopsy of the tumors just before mastectomy. Both the drill biopsy and surgical specimens were assayed for ER and PR in the cytosol and nuclear fractions by EIA. ER and PR in the cytosol fraction (ERc and PRc, respectively) of the drill biopsy specimens (DBS) correlated very well with those of the surgical specimens (SS): ERc (DBS) = 1.02 X ERc (SS) + 3.85 fmol/mg protein (r = 0.958) and PRc (DBS) = 1.05 X PRc (SS) + 3.87 fmol/mg protein (r = 0.958). ER and PR in the nuclear fraction (ERn and PRn, respectively) of the drill biopsy specimens also correlated very well with those of the surgical specimens: ERn (DBS) = 1.02 X ERn (SS) + 59.18 fmol/mg DNA (r = 0.932) and PRn (DBS) = 0.98 X PRn (SS) + 54.28 fmol/mg DNA (r = 0.898). These results demonstrate that EIA for ER and PR of the drill biopsy specimens is a very useful method for the estimation of the receptor status of breast cancers.

Biopsy↗
PubMed1989

Influence of adjuvant chemotherapy for operable breast cancer on results of treatment at relapse.

The influence of adjuvant chemotherapy (ACT) for operable breast cancer on the results of systemic therapy at relapse was retrospectively studied in 62 patients with recurrent disease. 32 had been treated with ACT [ACT (+) group] and the others had not [ACT (-) group]. The response rate (CR + PR) to the first treatment was 22% in the ACT (+) group and 43% in ACT (-) group. It is suggested that relapsing patients with a history of ACT respond poorly to the treatment as compared to those not receiving it.

Breast Neoplasms↗
PubMed1989

Influence of 1 alpha,25-dihydroxyvitamin D3 on the development and steroid hormone receptor contents of DMBA-induced rat mammary tumors.

The influence of 1 alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on the development and steroid hormone receptor contents of 7,12-dimethylbenzanthracene (DMBA)-induced rat mammary tumors was evaluated. Neither the incidence nor the size of the tumors was affected by the 1,25-(OH)2D3 treatment (1 or 2 micrograms twice a week for 16 weeks) but estrogen and progesterone receptor contents of the tumors were significantly lower in 1,25-(OH)2D3-treated groups as compared to the control group. These results demonstrate that 1,25-(OH)2D3 at doses producing mild hypercalcemia does not affect the development of DMBA-induced rat mammary tumors but decreases the estrogen and progesterone receptor contents of the tumors.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1989

[Syrinx-like artifact on MR images of the spinal cord].

We evaluated the syrinx like artifact on midline sagittal MR images of cervical spine. This artifact appeared as linear regions of low intensity along the length of the spinal cord. This artifact was frequently seen. And, when it appear as a single midline band, it mimics pathological conditions such as a syrinx. We found that this artifact eliminated by increasing the number of phase encoding steps, or decreasing the field of view. These method were useful for differentiation of artifact from syrinx.

Cervical Vertebrae↗
PubMed1989

[The effect of thyroid hormone on the growth of thyroid cancer].

Thyroid cancer is well known to be hormone sensitive as well as breast cancer, prostatic cancer, and endometrial cancer of the uterus. Various experimental results suggest that the growth regulation for thyroid cancer, as well as the normal thyroid gland, appears to depend upon the TSH (Thyroid stimulating hormone) receptor on cell membranes. Differentiated thyroid carcinoma cells possess TSH receptor, although anaplastic carcinoma cells do not; therefore suppression therapy of TSH with thyroid hormone is considered to be effective against differentiated thyroid carcinoma. It has been recognized that some recurrent differentiated thyroid cancers cause regression in size in response to treatment with thyroid hormone. But the administration of the thyroid hormone after the operation for the differentiated thyroid carcinoma does not necessarily enhance the survival rate. To analyze the difference in survival rate is very difficult because of the excellent survival rate of thyroid cancer patients after the operation. It is hoped that further clinical study and laboratory investigation about suppression in adjuvant therapy for differentiated thyroid cancer will give us a conclusive answer.

Adolescent↗
PubMed1989

[Long-term survival in patients with breast cancer after intra-arterial infusion chemotherapy].

Twenty two patients with locally advanced breast cancer survived for more than 5 years after intra-arterial infusion chemotherapy (IA). In this study, we compared these long-term-survivors with thirteen cases who died within 2 years. The results were as follows. (1) ER positive rate of the long-term-survivors (90%) was significantly higher than in short-term-survivors (25.0%). (2) There was no difference between the response rates of each group; 63.2% in long-term-survivors vs. 53.8% in short-term-survivors. (3) Adjuvant endocrine therapies were carried out in the former group, and their D.F.I. were considerably longer than in the latter group. (4) Common sites of recurrence in long-term-survivors were soft tissues and bones, compared with visceral in short-term-survivors. Post-recurrence survivals of the former were, also, longer than in the latter. From these results, we confirmed that preoperative IA and following adjuvant endocrine therapies induces favorable results in the treatment of hormone sensitive breast cancer.

Breast Neoplasms↗
PubMed1988

Results of surgical treatment for sternal metastasis of breast cancer.

Nine patients with solitary sternal metastasis of breast carcinoma were treated aggressively, with partial (n = 8) or total (n = 1) resection of the sternum. Parasternal and mediastinal lymph node dissection also was performed concomitantly for every patient. Chest wall defects were reconstructed with acrylic resin plate (n = 3) or rectus abdominus myocutaneous flap (n = 6). All patients received chemoendocrine therapy postoperatively. The median survival of these nine patients was 30 months. The prognosis of the patients (n = 4) with the mediastinal or parasternal lymph node metastasis were poor and all of them died of second relapse within 30 months. The prognosis of those (n = 5) without the lymph node metastasis, however, was quite favorable; three survived more than 6 years. These results suggest that sternectomy should be indicated for the solitary sternal metastasis when no evidence of systemic spread is noted since it can improve the quality of life and occasionally may result in long-term survival.

Adult↗
PubMed1988

Augmentation of anticancer effect with angiotensin II in intraarterial infusion chemotherapy for breast carcinoma.

We investigated the effect of angiotensin II (AT II) on blood flow in breast cancer patients using 81mKr and found that it increased tumor blood flow 2.3-fold while decreasing blood flow in adjacent normal tissue 0.7-fold. We, then, used AT II in conjunction with intraarterial infusion chemotherapy (IAC) for locally advanced breast cancer in order to increase drug delivery to the tumor and enhance its anticancer effect. Eleven patients (from 1976-1981) received IAC with doxorubicin through the internal thoracic and subclavian arteries, alternately, for 10 days (AT II- group). Twenty-four patients (from 1981-1985) received IAC with doxorubicin and concomitant infusion of AT II (1.3 micrograms/min through the internal thoracic artery and 2.6 micrograms/min through the subclavian artery) (AT II+ group). The response rate of the primary breast tumor was higher in the AT II+ group (92%) than in the AT II- group (73%) (P = 0.66). Complete tumor necrosis was 46% in the AT II+ group, but only 27% in the AT II- group (P = 0.51). These preliminary results suggest that the anticancer effect of IAC for breast cancer can be enhanced with concomitant infusion of AT II.

Adult↗
PubMed1988

Management of inflammatory carcinoma of the breast with combined modality therapy including intraarterial infusion chemotherapy as an induction therapy. Long-term follow-up results of 28 patients.

Twenty-eight patients with inflammatory breast cancer were treated with combined modality therapy consisting of (1) intraarterial infusion chemotherapy (IA chemotherapy) through the internal thoracic artery and subclavian artery, (2) surgical ablation, (3) extended radical mastectomy, and (4) adjuvant chemotherapy in that order. The IA chemotherapy included Adriamycin (n = 14) and mitomycin C plus 5-Fluorouracil (n = 14) were used. The response rate of the primary breast lesions to IA chemotherapy was as high as 83%, and complete necrosis of the tumor was histologically documented in 43% of the cases. The median interval from the initiation of IA chemotherapy to surgery was 7 weeks. Toxicity was acceptable and every patient completed the treatment. The 5- and 10-year disease-free survival rates were 59% and 53%, respectively. These results suggest that IA chemotherapy is a very useful induction therapy for inflammatory breast cancer in terms of excellent local effects and the short time required for therapy before surgery.

Adult↗