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Biomedical subjects

K Minami

Publications and source records attributed to K Minami.

At least 379 records · Page 21Linked to original sources
PubMed1979

Effect of Propionibacterium acnes on the cellular immune responses to tumor-specific antigens on malignant rat liver cells.

The effect of Propionibacterium acnes on the cellular immune responses to tumor-specific membrane antigens was investigated by microcytotoxicity assays (MA) and 51Cr release assays (CRA) with use of mesenteric lymph node cells (LNC) of syngeneic BD IV and BD VI rats. BD rat liver cell lines transformed in vitro by chemical carcinogens were used as target cells with tumor-specific antigens. By MA, the LNC from rats that were inoculated with malignant liver cells under the adjuvant effect of heat-killed P. acnes showed significant cytotoxic response to the target cells but not to nonmalignant liver cells. By CRA, these LNC did not show specific cytolysis to the malignant liver cells. Assays with various target cells derived from BD rat liver and inhibition tests with syngeneic and xenogeneic antisera against tumor-specific antigens on the malignant liver cells proved that LNC reacted with tumor-specific individual or tumor-specific cross-reacting antigens on the malignant liver cells. Cytotoxic responses against the malignant liver cells were not demonstrated even by MA with use of the LNC from rats inoculated with either the malignant liver cells or P. acnes alone. LNC from the rats inoculated with both nonmalignant liver cells and P. acnes were not cytotoxic to malignant or nonmalignant liver cell lines.

Animals↗
PubMed1978

Contribution of T cell-mediated immunity to the resistance to staphylococcal infection.

Abscess formation in nude mice after subcutaneous inoculation of Staphylococcus aureus (S. aureus) was more extensive and prolonged as compared with that in phenotypically normal littermates. Abscess formation in nude mice was augmented markedly by whole-body irradiation. Not only T cell-mediated immunity but also radiosensitive, nonimmune phagocytosis appear to contribute to the resistance against staphylococcal infection.

Abscess↗
PubMed1978

Hepatitis Bs antigen, antigen subtypes and hepatitis Bs antibody in Ghana.

In a study on the prevalence of hepatitis Bs antigen and antibody in 374 Ghanaian patients, 305 of whom had hepatic diseases and sixty-nine with non-hepatic diseases, it was found that Bs antigenaemia and antibody rates were, respectively. 38.7% and 4.3% in patients with hepatic diseases. In patients with non-hepatic diseases the corresponding values were 14.5% and 10.1% respectively. It was further found that both antigenaemia and antibody rates were higher in females than in males with hepatic diseases. However, HBs antigenaemia was highest in male children aged 0-5 years with hepatic disease than in their female counterparts. The antigenaemia rate was highest among both sexes in the 11-20 year age group. No antibody was detected in both male and female patients aged 6-10 years. Hepatitis Bs antigen was detected in all seven regions of the nine in the country surveyed. On the other hand, HBs antibody was detected in patients with hepatic diseases as well as in those with non-hepatic diseases in all the seven regions surveyed except in the Eastern Region. The only subtype detected in the survey was ayw.

Adolescent↗
PubMed1978

Propionibacterium acnes-mediated humoral immune responses to tumor-specific antigens on rat liver cells transformed in vitro by chemical carcinogens.

Effects of Propionibacterium acnes on production of antibodies against tumor-specific membrane antigens were investigated in syngeneic inbred BD IV and BD VI rats. BD rat liver cell lines transformed in vitro by chemical carcinogens were used as target cells for tumor-specific antigens. By membrane immunofluorescence, antibodies against these rat liver cell lines were detected in syngeneic BD rat sera. Antibodies were produced in syngeneic rats under the adjuvant effect of heat-killed P. acnes only. In assays with various target cells and absorption experiments, the antibodies reacted with a tumor-specific individual antigen or tumor-specific cross-reacting antigen on the surfaces of transformed BD rat liver cells. No antibodies against these antigens were found in the sera obtained from syngeneic rats immunized with either the transformed cell lines or P. acnes but not with both. Freund's complete adjuvant did not induce antibodies against these tumor-specific antigens.

Animals↗