Neurodevelopmental screening of 5-year-old children.
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Child Development↗
Biomedical subjects
K Michelsson
Publications and source records attributed to K Michelsson.
Neonatal risk factors and later neurodevelopmental disturbances.
Background factors of developmental outcome in a group of 386 neonatal 'at-risk' infants and 107 controls were examined in a prospective nine-year follow-up study. Dichotomized outcome variables were computed for each of the assessments; neurodevelopmental, motor, psycholinguistic, cognitive and school progress. In the study group, 17 to 29 per cent were found to have significant problems, compared with 10 to 17 per cent of the control group. Children with low birthweight, neonatal neurological symptoms or several neonatal disorders were found to have most problems at the age of nine years. In stepwise logistic regression analyses, smallness for gestational age, neonatal signs of cerebral depression and low social-class were found to be the most significant predictors of neurodevelopmental problems at age nine. Factors suggesting intra-uterine hypoxia or poor nutrition were also associated with developmental problems. The background pathology of the neonatal conditions seemed to be of more importance than the neonatal manifestations themselves.
Brain↗
Prediction of early school-age problems by a preschool neurodevelopmental examination of children at risk neonatally.
A group of 350 children who had had neonatal developmental risk-factors were assessed at the age of five years with a neurodevelopmental examination. At nine years they were assessed again for neuropaediatric, motor, psycholinguistic, cognitive and school-achievement problems. (Children with major handicaps were excluded). Poor performance at age five was significantly associated with failure in the nine-year examinations and with school problems. Sensitivity of the five-year neurodevelopmental examination in predicting problems at nine years was 0.30 to 0.50, and its predictive value for an abnormal performance was 0.30 to 0.60. Predictively, the neurodevelopmental examination was accurate in defining children without later problems, but less satisfactory in defining those who did develop problems. Multiple linear regression analyses between the neurodevelopmental examination and the scores at nine years revealed low explanatory power. A shortened neurodevelopmental examination, based on the best predictors, seemed to be as efficient as the full examination.
Brain Damage, Chronic↗
Neurodevelopmental significance of minor and major congenital anomalies in neonatal high risk children.
Minor and major congenital anomalies were studied in 395 neonatal risk children and 107 normal school children at the age of nine in the context of follow-up of the risk children. The purpose of the study was to evaluate the impact of early prenatal disturbances on the long term prognosis. Minor physical anomalies (MPA) were scored by a weighted scoring system modified from that of Waldrop and Halverson. The children with minor or major congenital anomalies performed worse in a cognitive test (WISC) and in a motor performance test. The differences were significant in the neonatal risk group. There were more small for gestational age (SGA) children in the anomaly group of the neonatal risk group as a whole and in the low birthweight group than in the non-anomaly group. Hyperactivity was associated with a high MPA score in the comparison group, but not in the study group. The results are consistent with earlier reports of associations between intrauterine growth disturbance and minor physical anomalies. Our findings suggest an additive effect of prenatal insults and neonatal risk factors in the origin of neurodevelopmental disturbances.
Attention Deficit Disorder with Hyperactivity↗
Ten-year follow-up of adolescent dyslexics.
A follow-up study of 26 dyslexics with an age range from 20 to 28 years revealed that reading and writing problems were essentially unchanged from the time of diagnosis 7-10 years earlier. The intellectual capacity of all subjects was normal. One of the ten who finished high school had started university studies. Sixteen (62%) had completed only the obligatory nine years of schooling. Fourteen (54%) were in practical occupations such as a cook, storeman, and truck driver. Our results suggest that with late diagnosis and no remedial treatment, dyslexia remains. The subjects report that their handicap has interfered with their choice of occupation.
Adult↗
Sound spectrographic cry analysis of infants with hydrocephalus.
Altogether 248 cries from 62 infants with hydrocephalus were analysed by sound spectrography: 92 cries from infants with congenital hydrocephalus and 52 cries from each of the groups with cerebral malformations, hydrocephalus as sequelae of meningitis, and after closure of a meningomyelocele. The cries were compared with 104 cries of normal healthy infants of corresponding age. The cry analysis showed that the most abnormal cries were seen in infants with congenital hydrocephalus and cerebral malformations. The pitch of the fundamental frequency did not differ from normal crying in cries of infants collected after recovery from meningitis and after closure of a meningomyelocele. The cries in hydrocephalus after meningitis showed more commonly flat melody types and the occurrence of bi-phonation.
Crying↗
Nine-year follow-up of infants weighing 1 500 g or less at birth.
A nine-year follow-up of 116 children born consecutively in 1971-74 with a birthweight of 1 500 g or less showed that 59 had died. Of those who were alive, four had severe motor and/or mental handicaps and three were blind because of retrolental fibroplasia. The low birthweight children without severe handicaps were found to have impaired motor function, speech defects and impaired school achievement more often than the controls. There was a significant correlation between the test results at the age of five and nine years, which indicates that children with school failure can be recognized and early remedial treatment started before school or on starting school.
Birth Weight↗
Cry score--an aid in infant diagnosis.
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Central Nervous System Diseases↗
School failure caused by dyslexia among adolescents visiting an adolescent unit.
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Achievement↗
Neurological, psychological and articulatory impairment in five-year-old children with a birthweight of 2000 g or less.
The study comprised 324 children with a birthweight less than or equal to 2000 g born in 1971-1974 at the Institute of Midwifery, Helsinki. The low birthweight (LBW) infants totalled 1.46% of the live-born during that time. At the age of 5 years 197 children were investigated; 15 had severe handicaps while 182 were without any immediate noticeable defects. The rest were not investigated for the following reasons: 86 had died, seven were severely handicapped and 34 could not be traced or the parents did not want to participate in the examination. The 197 children were given a neurodevelopmental screening examination, psychological and articulatory tests. A score of greater than or equal to 23 in the neurodevelopmental screening examination was noted in 8% of the controls, in 87% of the severely handicapped and in 34% of children without severe handicaps. All psychological test results differed significantly from those of the controls. The articulatory tests showed that the speech problems were more common among the LBW children. According to the teachers' assessments at the age of 9 years, 32% of the LBW children were in need of special education, compared with 12% of the controls. A significant correlation was found between the test results at 5 years and the school achievement at the age of nine.
Achievement↗
Sound spectrographic analysis of pain cry in preterm infants.
Sound spectrographic cry analysis was performed on 302 cries of 48 preterm infants born at 30-37 gestational weeks. The cries were recorded during the first week of life and thereafter weekly until the infants were discharged. The control series comprised 54 cries from 27 fullterm healthy infants. The results showed that the cries of the smallest prematures compared with the controls were shorter, more high-pitched, and included bi-phonation and glide more often. The cry characteristics changed with increasing conceptual age and the older the child the more the cry pattern resembled that of the fullterm. The cries of the preterm infants when they had reached 38 conceptual weeks were similar to those of newly born fullterm infants. The results indicate that the gestational age should be taken into consideration in cry analysis.
Acoustics↗
[Minimal brain dysfunction].
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Attention Deficit Disorder with Hyperactivity↗
Efficacy of salbutamol in treatment of infant pertussis demonstrated by sound spectrum analysis.
The value of sound spectrum analysis (sonography) as an indicator of the severity of symptomatic pertussis was assessed in four infants aged 3 weeks to 5 months. Coughing paroxysms and whooping could be clearly distinguished and measured on the sonogram. Sonography was then used to evaluate the effects of oral salbutamol on pertussis. The drug reduced the frequency and shortened the duration of the whoops; however, it did not have corresponding effect on the cough. Salbutamol seemed to relieve the laryngeal spasms and consequently eased the infant's breathing difficulties.
Albuterol↗
Cry analysis in infants with infectious and congenital disorders of the larynx.
Thirty induced pain cries from the same number of infants with infectious or congenital disorders of the larynx (infectious laryngitis, laryngomalacia, paresis of the recurrent nerve and subglottic stricture) have been analyzed by means of sound spectrography. For each cry 21 phonetic features have been evaluated. This cry material was then compared with 120 pain cries from healthy infants. In the pathological group a significant increase could be noted in the occurrence of the following cry attributes: second pause, abnormal melody types (rising, falling-rising, flat and no melody types), instability of the fundamental frequency, bi-phonation, vibrato, half-voiced voice quality, noise concentration, and inspiratory stridor. Furthermore, a significant decrease could be noticed in the occurrence of voiceless cries, falling and rising-falling melody types, and glottal roll. These findings show that such spectrographic features as very high maximum and minimum pitch, bi-phonation, gliding, and abnormal melody type occur more often in cries of infants with central nervous system involvement. Moreover, such parameters as instability of the fundamental frequency and noise concentration as indicators of neurologic disorders need further consideration. Except features of inspiratory stridor, this study revealed no really clear parameters typical of peripheral diseases of the vocal tract.
Central Nervous System↗
[Effect of antenatal hypoxia on the nature of the cry of newborn rats].
Spectrography was used to examine spontaneous and pain (induced by pricking the foot with a needle) cries of newborn Wistar rats of the first three days of life. Three groups of animals were employed: non-operated control rats, those which suffered hypoxia on days 17-21 of gestation (clamping of the umbilical cord), and control rats born to operated females. The cries were recorded on Kometa or Vesna tape recorders and analyzed with the use of a Sona Graph, type 7029A. Antenatal hypoxia was found to produce an increase in the minimum and maximum pitches of fundamental frequency and to a decrease in the duration of the cry. It is likely that the changes in the cry are related to the impairment of the thalamic and hypothalamic nuclei and external respiration distress because of hypoxia.
Animals↗
Neurodevelopmental screening at five years of children who were at risk neonatally.
A neurodevelopmental screening test with cumulative scoring for abnormal test responses was performed on 845 five-year-old Finnish children who, in the newborn period, had had disorders which placed them in a high-risk group, and on 70 controls. The results showed a significant difference between the neurodevelopmental scores of the risk-group children and those of the controls. The scores were higher if the child had had many of the risk factors simultaneously. Boys had significantly higher scores than girls. The mean scores also varied between different risk factors. It is evident that slight neurodevelopmental deviations at the age of five years can derive from disorders in the newborn period.
Child, Preschool↗
Cry analysis of infants with karyotype abnormality.
Sound spectrography was used to analyze 135 pain cries from 14 infants with a karyotype abnormality. At the time of the cry recording the children were from one day to seven months old, except for one child who was 2 years 10 months at the second recording. The cries were compared with 30 pain cries from 15 healthy infants of corresponding age. The children with an abnormality of chromosome 4 or 5 had cries with a significantly higher fundamental frequency than the control infants. Additionally, the cry in the "Cri-du-Chat" syndrome had a flat, monotonous melody type. The cries of infants with 13- or 18-trisomy were hoarse, low-pitched, with the shift parts absent. The cries in karyotype abnormalities were also different from pain cries of infants with other disorders involving the central nervous system. This study suggests that cry analysis can provide a valuable indication of the presence of a chromosome anomaly.
Abnormalities, Multiple↗
[Spectrographic analysis of the crying of infants with laryngeal disorders].
Twenty induced pain cries from the same number of infants with laryngeal disorders (infectious laryngitis, laryngomalacia, recurrens paresis and subglottic stricture) have been analyzed by means of sound spectrography. For each cry 21 phonetical cry features have been evaluated. This cry material was then compared with 120 pain cries from healthy infants. In the pathological group a significant increase could be noted in the occurrence of the following cry attributes: second pause, abnormal melody types, instability of the fundamental frequency, biphonation, vibrato, half-voiced voice quality, and inspiratory stridor. Furthermore, a significant decrease could be noticed in the occurrence of voiceless voice quality and glottal roll. For the other cry parameters no significant differences have been observed. In the light of these findings, the neuropathognomic significance, which has been up to now attached to such spectrographic features as very high maximum pitch, biphonation, gliding, and abnormal melody type, should not be taken too strictly. Moreover, one may conclude that the actual state of cry spectrography does not permit us to regard such parameters as instability of the fundamental frequency and noise concentration as indicators of neurologic disorders. On the other hand, the features inspiratory stridor, vibrato and tonal pit seem, to be to a certain extent typical of peripheral diseases of the vocal tract.
Crying↗