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Biomedical subjects

K Matsui

Publications and source records attributed to K Matsui.

At least 721 records · Page 40Linked to original sources
PubMed1981

[Rearing trial of a feed for Shiba goats].

Shiba goats are among the widely used for research purposes as laboratory animals and there is an increasing need for development of a suitable feed of reasonably constant nutrient composition and quality in pellet form for them. Preliminary studies yielded a pellet feed satisfactorily palatable and adequate as a maintenance ration for this species. The present experiments were conducted to assess the pellet feed for usefulness in rearing Shiba goats, in comparison with a conventional ration which has long been used at the Stock Farm of Tokyo University. No significant intergroup differences were observed as to VFA proportions in the rumen fluid, hematologic parameters or blood chemical constituents between the pellet feed and conventional ration. Animals maintained on the experimental pellets ad libitum displayed a significant decrease in apparent digestibility.

Animal Feed↗
PubMed1981

[Automatic recording and analysis of the ambulatory dynamics of cerebellar ataxic mice-rolling mouse Nagoya, Reeler and Weaver (author's transl)].

Rolling mouse Nagoya (Rolling) was found by Dr. Oda, Univ. of Nagoya, in 1969 as a spontaneous mutant and is characterized by the abnormal gait which appears about 2 weeks after birth. The origin and its mechanism of the motor abnormalities of Rolling has not yet been cleared, but this mouse is now grouped to be one of the cerebellar ataxic mice. The locomotion of the adult mice was automatically recorded and quantitized into the counts of each size of movements, and the gait of Rolling was compared with those of the nonaffected normal mouse, Reeler and Weaver. The reproducibility of the locomotion of the mice was fairly good regardless of the cage used and the observation time (less than 10 min.). Affected mice showed significantly small number of counts in size of 1/4 and 1/8 (about 6 and 3 cm in practice) of movements due to toppling during gait compared with the nonaffected normal mice. The gait of Rolling was not completely discerned from the Reeler or Weaver in the spectrum of movements. However, in locus of movements, each mutant showed the specific features of the motor abnormalities. Results presented in this paper suggest that Rolling is similar to Reeler and Weaver with regard to the cerebellar ataxia.

Animals↗
PubMed1981

[Postnatal development of the heart in the golden hamster (author's transl)].

The postnatal development of the heart was morphometrically followed in growing golden hamsters to obtain basic information on the development of cardiovascular system of the animal. Correlations among the body weight, heart weight, heart width and length, atrial weight, right ventricular weight and left ventricular (inclusive of ventricular septum) weight, and thicknesses of right and left ventricular free walls were examined. A linear correlation was observed consistently between width and length and between body weight and atrial weight throughout the observation period. On the other hand, the results indicated that in the correlations seen between thicknesses of right and left ventricular free walls, body weight and heart weight, body weight and ventricular weight, and right and left ventricular weights, an alteration point existed at 40 to 50 days of age, which coincided with the period of achieving sexual maturity. The data have shown that the various morphometric elements of the heart correlated linearly with the body weight during the early life till 40-50 days of age, and after wards only those concerned with the left ventricular chamber preponderated as the body weight increased.

Animals↗
PubMed1980

Chromosomal alterations of rat cell lines transformed by human adenovirus type-12 virion, whole DNA and left-end DNA fragments.

A normal rat cell line, 3Y1-B clone 1-6 (3Y1) and its adenovirus (Ad) type-12-transformed derivatives, W4 (transformed by Ad12 Virion), WY3 (transformed by Ad12 whole DNA), CY1-1 (transformed by the Ad12 EcoRI-C fragment, left 16.5%), GY1-1 (transformed by the Ad12 HindIII-G fragment, left 6.8%) and HY1 (transformed by the Ad12 Acd-H fragment, left 4.7%) were studied cytogenetically. 3Y1 and some of the transformed cell lines (W4, WY3 and GY1-1) were diploid or pseudodiploid, while others (CY1-1 and HY1) were hypotetraploid. A metacentric marker M1 was detected in GY1-1 cells and another marker M2 in W4 and CY1-1 cells at a high frequency. By the Giemsa banding technique, the metacentric markers M1 and M2 from these fully transformed cell lines were identified as isochromosomes derived from 1q (M1) and 3q (M2), respectively. On the other hand, the markers were detected only at a low frequency in incompletely transformed HY1 cells. However, hypersomy in chromosome No. 1 was observed at a high frequency in this cell line. It can be concluded that hypersomy of chromosomes No. 1 or 3 found in transformants and metacentric markers found in complete transformants are characteristic features in rat cells transformed by Ad12.

Adenoviruses, Human↗
PubMed1980

The distribution of Gc subtypes among the mongoloid populations.

The polymorphism of Gc (group-specific components) has been investigated for a series of 3,160 individual samples from 11 Mongoloid populations in Asia and North and South America by isoelectric focusing on polyacrylamide gels. The samples fall into six Gc phenotypes which can be explained by the three common alleles, Gc1F, Gc1S, and Gc2, together with several variant phenotypes explained as the heterozygotes for the three common alleles. The distribution of Gc1F suballele appears to be considerably different from population to population among Mongoloids, ranging from 0.105 (Machiguenga Indians, Peru) to 0.609 (Kadazan, Borneo). A clear geographic cline from Southeast Asia into South America in Gc1F allele was observed in the populations. In general, Gc1F allele frequencies are lower in European populations and higher in African populations. The range of variability in the Gc1F values observed among the Asiatic populations is between the Africans and the Europeans.

Alleles↗