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Biomedical subjects

K Masuda

Publications and source records attributed to K Masuda.

At least 631 records · Page 35Linked to original sources
PubMed1986

[The application of multivariate analysis to the radioallergosorbent test (RAST)].

Multivariate statistical analyses using principal component analyses (PCA) and Mahalanobis' method were applied to the quality control of radioallergosorbent test (RAST). Mites and foods allergen were analyzed by PCA method, and foods allergen were analyzed by Mahalanobis' method. The vast differences in the distribution on titers among the mites and the foods were observed. To evaluate the results of a test and the quality of kits for test statistically, it should be better to use multivariate analyses such as PCA or Mahalanobis' method.

Allergens↗
PubMed1986

[Endoscopic resection with local injection of HSE (ERHSE) in early gastric carcinomas].

We have developed a new therapeutic method of endoscopic resection with local injection of HSE (ERHSE) for the early gastric carcinomas. ERHSE was performed for a total of seventy eight lesions of seventy five cases. Seventy eight early gastric carcinomas consisted of IIc (35), IIa (32), I (6), IIa + IIc (4) and IIc + IIa (1). Ten cases out of 75 underwent gastrectomy, because the invasion of carcinoma was detected in the submucosa or to the resected margin. No evidence of local recurrence has been obtained in the sixty five cases treated by this method.

Epinephrine↗
PubMed1986

[A case of successfully resected abdominal aortic aneurysm complicated by arteriocolic fistula].

A 80 year-old man was admitted to our hospital with profuse rectal bleeding. Two weeks prior to admission he was diagnosed as having abdominal aortic aneurysm when he had first herald of rectal bleeding. Aortoenteric fistula was strongly suspected and patient underwent emergency operation. Bilateral axillofemoral bypass were first constructed in order to avoid contamination in hte peritoneal cavity. On laparotomy aneurysm was contaminated because of arteriocolic fistula and resection of aortoiliac aneurysm and Hartmann procedure were performed. In the postoperative course, formation of an intra-abdominal abscess, obstruction of the left axillo-femoral bypass graft and enlargement of a residual aneurysm occurred. The prolonged antibiotic therapy was successful and additional repair operations were performed. Abdominal aortic aneurysm complicated with arteriocolic fistula is a rare but lethal disease. To our knowledge, only 13 cases have been reported in the literature including our case. Eleven patients were operated but only 3 survived. Construction of an extra-anatomic bypass, avoidance of an anastomosis in unprepared bowel and aggressive use of antibiotics are recommended because fecal contamination to the aneurysm is inevitable in most cases.

Aged↗
PubMed1986

Development of synthetic lung surfactants.

We have previously reported the development of a reconstituted lung surfactant consisting of an organic solvent extract of natural bovine lung surfactant supplemented with synthetic lipids. This "artificial" surfactant was used successfully to treat surfactant deficiency states both in animals and humans. We now report on the successful testing of a synthetic lung surfactant consisting of a lipid-bound protein isolated from natural lung surfactant and the lipids present in the "artificial" lung surfactant and now used in the same concentration but in a synthetic, commercially available form. The synthetic lung surfactant possessed the in vitro and in vivo surface properties characterizing the "artificial" lung surfactant. In order to identify the components of the synthetic lung surfactant that are responsible for the required surface properties, a series of 25 simple mixtures was prepared. Of these, three possessed surface properties very similar to those of the "artificial" lung surfactant and the synthetic lung surfactant, in vitro as well as in vivo. These three mixtures had four components in common. Besides dipalmitoyl phosphatidylcholine and the lipid-bound protein, they each had a saturated fatty acid, palmitic or stearic, and they each had an acidic phospholipid, phosphatidylglycerol or phosphatidylserine.

Animals↗
PubMed1986

Population and proportion of component cells in preretinal membranes.

Cell population and proportion of each component cell type in preretinal membranes formed after retinal detachment were studied by light microscopy (LM) and transmission electron microscopy (TEM). The preretinal membranes were surgically obtained from 20 proliferative vitreoretinopathy (PVR) and 7 macular pucker patients. A thick section from the middle of Epok-embedded specimens stained by toluidine blue was photographed by LM and the area was determined. The cell nuclei were counted on the light micrographs, and the membrane cell population was estimated. All the cells in an ultrathin section of each membrane were photographed by TEM and classified into six types: pigment epithelial cells, astrocytes, macrophages, fibroblasts, cells of other types and unclassified cells. The proportion of these cell types in each membrane was analyzed. There was no significant correlation between the cell populations and duration of retinal detachment or grades of PVR. The proportions of macrophages and pigment epithelial cells were large in early stages of PVR and decreased in late stages, whereas those of astrocytes were the same as those of macrophages or pigment epithelial cells in the early stage and then increased as the duration of retinal detachment became prolonged. These results suggest that macrophages and pigment epithelial cells play important roles in the initiation of preretinal membrane formation in PVR, and that astrocytes participate in the development of rigid membranes. The main component cells in the preretinal membranes obtained from macular pucker patients were astrocytes. The population and the proportion of the astrocytes were almost similar among different stages. These facts suggest that astrocytes play an important role in preretinal membrane formation in macular pucker.

Cells↗
PubMed1986

[Histological findings determining disease-free survival rate].

Histological findings of malignant tumors were reviewed in relation to the prognosis following surgery, radiotherapy and/or chemotherapy. To say the histological grading of malignancy by differentiation (maturation), estimation of it seemed to be subjective and it did not always correlate with the disease free survival rate. Histological findings which indicated a high degree of tumor-host interaction were a good predictor of the prognosis as well as the cell type, and the disease free survival rate of the cases with these findings was relatively higher following not only surgery, radiotherapy but also chemotherapy.

Brachytherapy↗