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Biomedical subjects

K Maeda

Publications and source records attributed to K Maeda.

At least 1,045 records · Page 58Linked to original sources
PubMed1991

[A study of victims of methylmercury poisoning outbreaks by age and sex in Minamata, Niigata and Iraqi outbreaks].

To investigate features of the incidence of methylmercury poisoning cases presumably caused by intake of polluted foods in Japan and Iraq, several populations exposed to polluted foods were analyzed by geography and/or occupation. Ratios of confirmed cases to the corresponding number by age and sex in the defined exposed population were calculated. The distribution of the ratios showed a unimodal age distribution for both males and females in the Japanese Minamata and Niigata population. On the contrary, in the Iraqi population, ratios distributed equally by age and sex groups, having no peaks. This difference between the two countries is probably due to the difference of ingestion by age and sex in fish and wheat, which was the primary source of methylmercury exposure.

Adolescent↗
PubMed1991

[A case of metastatic rib tumor from thyroid cancer confirmed by the presence of thyroglobulin].

A 63-year-old female, with a chief complaint of right chest pain was referred to our hospital because of an abnormal right chest wall shadow on chest X-ray. A rib tumor was suspected based on her chest CT scan. Percutaneous needle biopsy yielded a diagnosis of well-differentiated adenocarcinoma. As metastatic rib tumor was suspected, the primary tumor was sought for. A thyroid gland nodule was recognized by ultrasonography, and the cytological diagnosis was class V. Immunohistological demonstration of the thyroglobulin studies of the rib tumor tissue revealed papillary and trabecular patterns of cell arrangement and the presence of thyroglobulin existence. Definitive diagnosis of metastatic rib tumor from thyroid cancer was established. Immunohistological examination is useful to confirm the diagnosis of metastatic cancer of thyroid origin.

Adenocarcinoma↗
PubMed1991

Accumulation of quinolinic acid in uremic serum and its removal by hemodialysis.

Quinolinic acid was first identified in uremic serum by use of gas chromatography/mass spectrometry. Quantification by selected ion monitoring revealed that the serum concentration of quinolinic acid was markedly increased in chronic hemodialysis patients, and that the acid could be removed by conventional hemodialysis. The serum concentration of quinolinic acid was weakly but significantly correlated with the serum uric acid concentration. Accumulation of quinolinic acid in uremic blood may be involved in the pathogenesis of anemia, suppressed immune system, and uremic encephalopathy.

Adult↗
PubMed1991

[Experimental study of partial arterialization of the portal vein on the dearterialized liver].

The influence of hepatic arterial obstruction on the hepatic circulation and tissue metabolism was studied between animals with and without partial arterialization of the portal vein. Mongrel dogs were divided into these groups: a group in which the collaterals to the liver were obstructed and the hepatic artery was dissected (hepatic artery ligated group); two groups in which an extracorporeal femoral artery-portal vein shunt was produced, and blood was sent by a Biopump at a rate of 100 or 200 ml/min (100 ml/min and 200 ml/min portal arterialized groups). The hepatic artery ligated group showed CO2 accumulation and acidosis in hepatic venous blood, reduction of oxygen supply, increase of oxygen consumption and marked increase of GOT and GPT. In the portal arterialized groups, sufficient oxygenation of portal blood was noted, and the oxygen demand and supply and tissue metabolism were kept approximately normal. The optimum flow rate for partial arterialization of the portal vein seemed to be 100 ml/min. At the flow rate of 200 ml/min, the original portal blood was reduced, leading to portal hypertension and increase of GOT and GPT. These results indicate that partial arterialization of the portal vein effectively preserves the liver function during the operation and in the early period after dissection of the hepatic artery.

Alanine Transaminase↗
PubMed1991

Effect of an oral adsorbent (AST-120) in rats with daunomycin-induced chronic renal failure.

The effect of an oral adsorbent (AST-120) was examined in rats with daunomycin-induced chronic renal failure. Sixteen pairs of daunomycin rats which had similar levels of proteinuria at 4 weeks after being injected with daunomycin were selected. One rat of each pair served as a control and was fed on a standard diet, while the other rats were fed on a diet containing AST-120. The blood creatinine and blood urea nitrogen (BUN) were significantly lower in the rats fed with AST-120 than in the controls. Moreover, the life span of the rats fed with AST-120 was significantly prolonged as compared to that of the control rats. These findings suggest that oral administration of AST-120 may help to prevent rapid deterioration of renal function in experimental chronic renal failure induced by daunomycin in rats.

Administration, Oral↗
PubMed1991

Generation of human autologous melanoma-specific cytotoxic T cells from tumor-involved lymph nodes.

Cytotoxic T lymphocytes (CTL) specific for autologous human melanoma have been successfully generated in vitro from tumor bearing lymph nodes without any stimulation by the autologous tumor. Tumor-involved lymph node cells (LNC) were cultured in serum free medium (AIM-V) containing 1,000 U/ml of recombinant interleukin-2. The best expansion and specific cytotoxicity of CTL were achieved in 4 to 6 weeks of culture. The predominant populations in cultured LNC-derived CTL were CD2+, CD3+, CD4-, CD8+, CD56-, and HLA-DR+ T cells. These data suggested that tumor-involved LNC may provide an alternative source for the generation of tumor-specific CTL in adoptive immunotherapy.

Antigens, CD↗
PubMed1991

[Immunohistological and histopathological study of the effect of PCB on the periodontal tissue].

We performed immunohistochemical and histopathological investigation on the inflamed gingiva from the patient with Yusho and on the periodontal tissue from PCB poisoned rats respectively. The results obtained were as follows. 1) In the gingiva from the Yusho patients, the proportions of plasma cells, B cells, T cells in the inflammatory cells and CD4/CD8 ratio were 47.9%, 18.3%, 10.7%, and 2.84, respectively. 2) In the periodontal tissue from rats with experimental periodontitis, we found no definitive difference between the PCB poisoned rats and the clinically healthy rats.

Animals↗
PubMed1991

The colonic patch graft as a new technique of enteroplasty: histological observations and absorptive functions.

BACKGROUND: A colonic patch graft technique which consists of a three-staged procedure, was developed in order to diminish ileostomy complications and to reconstruct rectoanal function in patients with extensive aganglionosis. The basic data on creation of the colonic patch graft remains uncertain. METHODS: Using 20 experimental dogs, a colonic patch graft was created by forming a longitudinal side-to-side ileocolostomy, followed in 10 weeks by severance of the colonic mesentery which feeds the anastomosed colon segment. Five weeks after division of the primary blood supply, histological studies of the walls of the colonic graft were carried out in 10 dogs. Effect of severance of the colonic mesentery on water and electrolytes absorption through the ileocolostomy segment was evaluated by single perfusion method in 10 dogs. RESULTS: The significant abnormality noted was marked thickening of the submucosal layer secondary to persistent lymphstasis. Other layers of the bowel wall were not abnormal including the mucosa, muscle layers, and intramural ganglion cells. The severance of the colonic mesentery belonging to the ileocolostomy segment did not affect its absorptive capacity for water and electrolytes. CONCLUSIONS: The histological findings support the observation that absorptive function in the mucosa of the colonic patch graft is not significantly disturbed, although lymphstasis is observed in the submucosa.

Animals↗
PubMed1991

A case of adult T cell leukemia complicated by proliferative synovitis.

A 60-year-old woman was admitted to our hospital with symmetrical arthritis of the knees. During the 2 years preceding admission, she had experienced recurrent arthritis. A histological examination of her synovial tissue showed prominent villous proliferation of the synovial cells, prominent vascularity throughout and an inflammatory infiltrate composed of abnormal mononuclear cells. Three months later, she developed fever, skin eruptions, lymphadenopathy and hepatosplenomegaly. She also had hypercalcemia and there was abnormal lymphocytosis in her blood smears. She was diagnosed as having adult T cell leukemia. Parenteral chemotherapy treatment with adriamycin and cyclophosphamide gave remission of all the manifestations of disease, including arthritis. Her leukemia recurred, however, and she died 6 months after the diagnosis was made.

Antineoplastic Combined Chemotherapy Protocols↗