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K M Lakin

Publications and source records attributed to K M Lakin.

75 records · Page 5Linked to original sources
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[Effect of fructose derivatives on platelet aggregation].

Fructose diphosphate, fructose monophosphate and inorganic phosphate decrease platelet aggregation. Fructose does not affect the function under study. The most pronounced antiaggregation action is displayed by fructose diphosphate which enhances calcium binding with thrombocytic membranes. The action of fructose diphosphate depends on the time of its presence in the blood channel. Fifteen minutes after injection the substance inhibits the formation of experimental thrombocytic thromboses. After one hour such an effect does not manifest since fructose diphosphate is absent from the blood flow by that time.

Animals↗
PubMedDate not supplied

[The effect of fluorinated prostaglandins on platelet aggregation].

The effects of fluorodeoxy prostanoids on platelet aggregability were studied. It was shown that introduction of fluorine into positions 9, 11 or 15 of prostaglandin F2 alpha led to enhanced proaggregation activity. The most active compound among fluorodeoxy analogs was 15-fluoro derivative; bisfluoro analog was moderately active, and 11-fluoro compound had the least activity. In the group of fluorodeoxy prostaglandins E2, a contrary effect was registered. Thus, the most active compound was 1-fluoride and the least, 15-fluoride. The incorporation of fluorine into position 15 of prostacyclin led to insignificantly lower antiaggregatory activity just as this modification of 6-keto-prostaglandin F1 alpha was accompanied by a dramatic increase in its ability to inhibit platelet aggregation.

Adenosine Diphosphate↗