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Biomedical subjects

K M Jensen

Publications and source records attributed to K M Jensen.

At least 91 records · Page 5Linked to original sources
PubMed1983

Transurethral prostatic resection in the treatment of prostatism with high urinary flow.

There were 51 patients with prostatism who were selected for transurethral resection of the prostate using clinical nonurodynamic criteria. Urodynamic evaluation revealed that 13 patients had preoperative maximum urine flow rates greater than 15 ml. per second. The favorable postoperative outcome in clinical and urodynamic terms in this group of patients with high preoperative urine flow is discussed.

Humans↗
PubMed1983

Comparison of concentrations of rifampin and a new rifamycin derivative, DL 473, in canine bone.

Constant-infusion experiments were performed in 14 dogs to determine the penetration into bone of rifampin and a new C-3 substituted rifamycin, DL 473. The drugs were assayed in cortical bone and medulla from tibia-femur and cortical and cancellous bone from rib. After identical dosage, the concentrations of DL 473 appeared to be higher, except in the medulla, although the serum concentrations of rifampin were almost twice as high as those for DL 473. The concentrations of both drugs in all bone areas were several times higher than their minimum inhibitory concentrations against pathogenic Staphylococcus aureus.

Animals↗
PubMed1983

Antibacterial activity of norfloxacin in the gastrointestinal tracts of rats.

The capacities of norfloxacin (MK-0366) and neomycin to reduce the numbers of bacteria in the gastrointestinal tracts of rats were evaluated. Results of a 3-day treatment with norfloxacin were compared with those of a 3-day treatment with neomycin. Both drugs significantly decreased gram-negative and gram-positive bacteria. Norfloxacin effected a significantly greater reduction in numbers of gram-negative bacteria than did neomycin. Norfloxacin also significantly increased the number of anaerobic bacteria. Although neomycin reduced gram-positive bacteria more effectively than did norfloxacin, this difference between the two drugs was not significant. Norfloxacin merits further study for potential as a bowel sterilant.

Animals↗
PubMed1983

Effect of pindolol on intraocular pressure in glaucoma: pilot study and a randomised comparison with timolol.

A pilot study on 10 consecutive patients with newly diagnosed glaucoma and a randomised double-blind study on 18 patients with glaucoma were carried out to investigate the effect of pindolol, a beta-adrenergic blocking agent, on the intraocular pressure (IOP) in patients with glaucoma. The studies showed that pindolol may reduce the IOP and that no significant difference between the effect of timolol 0.5% and of pindolol 0.25% could be demonstrated. The serum concentration of pindolol was measured in 9 of the patients, but none had measurable serum levels.

Clinical Trials as Topic↗
PubMed1983

Significance of prostatic weight in prostatism.

In addition to routine evaluation, 68 patients with prostatism underwent blinded urodynamic testing prior to transurethral prostatectomy and were reexamined symptomatologically and urodynamically at 3 and 12 months after surgery to determine if prostatic weight could predict postoperative outcome. Resected prostatic weight correlated with estimated weight at cystoscopy and with obstructive symptoms, but not with urodynamic variables of infravesical obstruction. Patients with small prostates improved symptomatologically to the same degree as patients with larger glands, although they did not improve to the same degree urodynamically. Prostatic weight, therefore, could not be used to predict the outcome of transurethral surgery.

Aged↗
PubMed1983

Urinary flow studies in normal kindergarten--and schoolchildren.

The problems in the evaluation of children with suspected infravesical obstruction are shortly reviewed. Based upon literature studies it is concluded, that an isolated urinary flow measurement determining the Qmax is a suitable procedure of screening. Due to different shortcomings of earlier published normal materials, we investigated the spontaneous urination of 205 normal children aged 3 to 13 years in their normal environment. The mictiograph was installed in the toilet of two kindergartens and one school, enabling the children freely to void into the machine upon desire. From the flow curves the following parameters were calculated: Q1 sec, Qmax, Qmax time, and the micturition time, all of them being related to the square root of the voided volume. The data were non-parametrically statistically processed, and the limits of normal values (2 1/2% and 97 1/2% percentiles) are defined for different groups of age and sex. Furthermore, the different flow curve patterns are described, and it is found, that in 90% of the cases they are identical to the adult pattern.

Adolescent↗
PubMed1982

Human prostatic tissue concentrations of rosoxacin.

The corresponding concentrations of rosoxacin in serum (S) and prostatic tissue (PT) were determined in 15 patients undergoing transurethral resection of the prostate because of benign prostatic hyperplasia. Rosoxacin concentrations were determined employing both bioassay and a high-pressure liquid chromatography procedure, with excellent correlation between the two methods. Two dosage schedules were followed, resulting in median serum concentrations of 3.6 and 5.8 microgram/ml, respectively. The ratio of PT/S was found to be fairly constant and surprisingly high, the median values being 0.46 and 0.56. These results indicate that concentrations of rosoxacin are obtained in prostatic interstitial fluid in the range of the minimal inhibitory concentrations for most of the gram-negative pathogens causing bacterial prostatitis and urinary tract infections. Acceptable drug concentrations also were determined in urine and cerebrospinal fluid. The results obtained in this study warrant further clinical trials for rosoxacin in the treatment of bacterial prostatitis and urinary infections.

4-Quinolones↗
PubMed1982

Contamination of urological wounds by aerobic bacteria. Transvesical prostatectomy used as a model.

The density of aerobic bacteria in the subcutaneous wound was quantified by the velvet pad rinse technique before (first stage) and after (second stage) opening of the bladder in 13 patients undergoing transvesical prostatectomy. Six patients had bacteria in the urine preoperatively (group A) and the same bacteria were isolated from bladder puncture during the operation and during second stage. Seven patients (group B) had sterile urine preoperatively and the bacteria isolated during first and second stage were commensals of the skin and the upper-respiratory tract. The bacterial density in group B was median 3.1 viable counts (v.c.) x 10(-1)/cm2 during first stage rising to median 4.7 v.c. x 10-1/cm2 during second stage, while group A showed an increase from median 4.3 v.c. x 10(-1)/cm2 during first stage to median 169,5 v.c. x 10(-1)/cm2 during second stage. The results of the study indicate the possibility of using selective antibiotic prophylaxis, with the relevant antibiotic for the bacteria isolated in the urine preoperatively, to reduce postoperative wound infection in urological surgery with opening of the urinary bladder.

Aged↗
PubMed1980

Determination of amitriptyline-N-oxide, amitriptyline and nortriptyline in serum and plasma by high-performance liquid chromatography.

A method for the determination of amitriptyline-N-oxide, amitriptyline and nortriptyline in serum and plasma has been developed. After extraction from serum or plasma the drugs were analysed by high-performance liquid chromatography. The detection limit was 10 ng/ml (2 ml serum or plasma actually used). The coefficient of variation for all three compounds was below 10%. Amitriptyline-N-oxide was found in rat plasma after an oral dose (10 mg/kg) of amitriptyline-N-oxide.

Amitriptyline↗
PubMed1979

Interaction of salicylates and other non-steroidal anti-inflammatory agents in rats as shown by gastro-ulcerogenic and anti-inflammatory activities, and plasma concentrations.

The interaction of salicylates and other non-steroidal anti-inflammatory drugs was studied in rats. Concurrent oral administration of sodium salicylate (SS) or salicylic acid (SA) and indomethacin (IND) significantly reduced the gastro-ulcerogenicity and the plasma concentrations of IND. Acetylsalicylic acid (ASA) failed to do so. IND had no significant influence on plasma concentrations of SA. Simultaneous administration of SS and IND intraperitoneally or subcutaneously showed the same pattern of interaction as for oral administration. Concurrent oral administration of SS and IND exerted similar anti-inflammatory activity as the single drugs. SS significantly antagonized the ulcerogenicity of ibuprofen and tended to antagonize the ulcerogenic activity of ASA, phenylbutazone, tolfenamic acid and naproxen. The results suggest that in rats SS and SA (but not ASA) interact with IND concerning both gastro-ulcerogenicity and plasma concentrations of IND (but not of SA) and that the interaction is systemic in nature. We propose that the ulcerogenic interaction might be explained partly by the reduced IND plasma concentrations and partly by a weaker inhibition by SS of the prostaglandin system in the rat stomach.

Administration, Oral↗
PubMed1979

A new anti-inflammatory derivative of imidazole which is less ulcerogenic than indomethacin in rats.

The mechanism of the anti-inflammatory activity and ulcerogenicity of (2-dimethylamino-1(2)-methyl) ethyl ester of the 1-(2-carboxyethyl)-2-(p-chlorophenyl)-4,5-bis-(p-methoxyphenyl)-imidazole (A-162-ester) was compared with that of indomethacin in rats and enzymatic preparations derived from other species. A-162-ester was found to be deesterified in plasma to A-162. A-162-ester was about 3 times less anti-inflammatory and about 17 times less ulcerogenic than indomethacin. A-162-ester, when given orally, decreased prostaglandin I2 (PGI2) biosynthesis by gastric mucosa. The IC50 was close to the ulcerogenic ED50. Indomethacin--in the same test--was 37 times more potent than A-162-ester and the PGI2 inhibition and ulcerogenic dose-response curves for indomethacin were parallel. In other in vitro systems of prostaglandin (PG) biosynthesis, the inhibitory activity of A-162 was comparable to that of indomethacin. It is concluded that the ulcerogenicity of indomethacin results from a high affinity of this drug to gastric mucosal wall PG-synthetase which leads to decreased PGI3 formation at this site. The relatively low ulcerogenicity of A-162-ester most probable results from a lower affinity of this drug to the same site.

Animals↗
PubMed1978

Determination of indomethacin in serum by an extractive alkylation technique and gas-liquid chromatography.

A method for determining indomethacin in serum has been developed, involving extractive alkylation, in which indomethacin is converted into its ethyl ester, and subsequent gas chromatographic determination of the ester. The method is specific and permits the determination of amounts down to 50 ng/ml in serum. The indomethacin concentration in serum was followed for 24 h after oral and rectal application and the results are compared with those reported in the literature.

Administration, Oral↗