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K M Chen

Publications and source records attributed to K M Chen.

At least 109 records · Page 6Linked to original sources
PubMed1987

Effects of exogenous fat emulsion on lymphocyte function in septic rats.

Effects of exogenous fat emulsion (Intralipid) on lymphocyte function were studied, in vivo, with rats. Abdominal sepsis was induced in Sprague Dawley rats by cecal ligation and puncture. Following a bolus infusion of the fat emulsion or normal saline, lymphocyte proliferations after stimulation with bacto-concanavalin A (Con A), phytohemagglutinin (PHA), and pokeweed mitogen (PWM) were evaluated in animals divided into the following groups: group I, non-septic rats receiving saline infusion (NS-S); group II, non-septic rats receiving the fat emulsion (NS-F); group III, septic rats receiving saline (S-S); group IV, septic rats receiving the fat emulsion (S-F). Results of the study demonstrated that lymphocyte function was not suppressed by the presence of sepsis, and infusion of the exogenous fat emulsion also did not lead to a suppression of the lymphocyte function in either the septic or the non-septic rats. The results obtained from a previous, as well as this present, study suggest that although infusion of exogenous fat emulsion may suppress the function of monocyte and polymorphonuclear cells, lymphocyte function is not affected.

Animals↗
PubMed1986

Functional changes in rat-liver mitochondria during the early phase of burn injury.

Using succinate as a substrate, the respiratory control ratios of liver mitochondria from burned male Sprague-Dawley rats with full skin thickness burns covering 20 per cent of the body surface area were increased at 15, 30, 45 and 60 min after burn, the peak being at 30 min post-burn. A sham group acted as control. In comparison with the sham group, the specific activity of succinic dehydrogenase was slightly decreased and the activities of cytochromes b and c + c were decreased significantly 30 min after burning. All the results suggest a lack of increased metabolic activity during the early phase of burn injury.

Animals↗
PubMed1986

Amyotrophic lateral sclerosis and parkinsonism-dementia on Guam: a 30-year evaluation of clinical and neuropathologic trends.

We reviewed the records of 279 Guamanian Chamorro patients with amyotrophic lateral sclerosis (ALS) and 293 patients with parkinsonism-dementia (PD), who had onset of symptoms between 1950 and 1979, to determine if there were changes in the clinical and neuropathologic features that might clarify the declining incidence rates in the past decade. There were no major temporal changes in the frequencies of physical findings or histopathologic features, but in the past three decades, an increase in age at onset was observed for both ALS and PD. There was also a shorter duration of illness in ALS and a longer duration in PD. Good correlation was found between the clinical and pathologic findings for both ALS and PD throughout this period.

Amyotrophic Lateral Sclerosis↗
PubMed1986

Antitumor effect of two-drug simultaneous or sequential use of cisplatin, vindesine or etoposide on human pulmonary adenocarcinoma cell lines in tumor clonogenic assay.

The antitumor effects of two-drug simultaneous or sequential use of cisplatin, vindesine or etoposide were examined in human pulmonary adenocarcinoma cell lines by human tumor clonogenic assay. Different tumor cell lines (PC-9, PC-13 and PC-14) that originated from the same histological cell type responded quite variably to simultaneous and/or sequential therapy. The antitumor effects of various sequential combinations of cisplatin, vindesine and etoposide depended strongly on the nature of the individual tumor cell line tested.

Adenocarcinoma↗
PubMed1986

Observations on the clinical presentations and the neuropathological findings of amyotrophic lateral sclerosis in Australia and Guam.

Among 20 consecutive autopsies of amyotrophic lateral sclerosis (ALS) occurring in Caucasians in Western Australia (WA), 85% were males. The median age of onset was 58.9 years and the average duration of illness was 2.4 years. Twenty-two randomly selected ALS occurring among natives in Guam also showed a male predominance of 75%, younger age of onset (median 48.5 years) and longer survival period (median 3.4 years). 45% of the WA patients presented with bulbar involvement at the time of first examination. These patients had the lowest median survival period of 1.5 years when compared with the other forms of ALS, the classic upper and lower motor system involvement and progressive muscular atrophy. Theneuropathologic lesions of ALS in WA and Guam were similar with the exception that neurofibrillary tangles were frequently present in the Guamanian brains. In 14%, neuronal loss, gliosis and frequency of tangles in the cerebral cortex especially in Ammon's horn, substantia nigra, and locus ceruleus, were sufficiently severe to indicate the coexistence of another disorder, Parkinsonism-Dementia Complex. This condition was not clinically recognized. In the WA cases only one patient had tangles in the brain and he had concurrent Alzheimers disease. While senile plaques were present in this patient they were usually absent in the Guamanian brains.

Adolescent↗
PubMed1986

Effects of exogenous fat emulsion (Intralipid) on chemotactic function of monocytes and polymorphonuclear cells in sepsis.

Effects of exogenous fat emulsion (Intralipid) on the chemotactic function of monocytes and polymorphonuclear (PMN) cells were studied in vivo with rats. Abdominal sepsis was induced in Sprague Dawley rats by cecal ligation and puncture. Following a bolus infusion of the fat emulsion or saline, chemotactic function of monocytes and PMN cells was evaluated in animals divided into the following four groups: Group I, non-septic rats receiving saline infusion (NS-S); Group II, non-septic rats receiving the fat emulsion (NS-F); Group III, septic rats receiving saline (S-S); Group IV, septic rats receiving the fat emulsion (S-F). Results of the study revealed that monocyte function was suppressed by the sepsis, whether saline or the fat emulsion was infused, and administration of the fat emulsion resulted in suppression of monocyte chemotaxis both in the non-septic and the septic rats. Although in this study chemotactic function of PMN cells was not significantly suppressed by the sepsis, administration of the fat emulsion again led to a suppression of PMN cell function, in both the non-septic and the septic rats. Results of the study confirmed that administration of an exogenous fat emulsion may suppress the chemotactic function of the monocytes and PMN cells and, in the presence of severe sepsis, infusion of the fat emulsion may lead to a further deterioration of immunologic function of the host. Special care, therefore, should be taken against the use of exogenous fat emulsion in septic individuals or in those at risk of infection.

Animals↗
PubMed1985

Gallstone ileus.

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Adult↗