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Biomedical subjects

K Kudo

Publications and source records attributed to K Kudo.

At least 361 records · Page 20Linked to original sources
PubMed1984

The suppression of insulin-specific immune responses by the administration of insulin-derivatized syngeneic cells and soluble lysates from these cells.

The results of this study demonstrated that the i.v. administration of insulin, in the form of a conjugate with either syngeneic spleen cells (SC) or peritoneal exudate cells (PEC), markedly reduced the capacity of recipient mice to develop insulin-specific immune responses, as manifested by diminished in vivo IgE antibody production and by depressed in vitro, lymph node cell proliferation responses, respectively. Furthermore, it was shown that i.v. injection of insulin-PEC conjugates induced the activation of suppressor cells that had the capacity to downregulate insulin-specific IgG plaque-forming cell (PFC) responses. Finally, it was also determined that freezing and thawing of the insulin-PEC conjugates resulted in the release of a soluble tolerogenic molecule and/or membrane preparation that could also markedly depress insulin-specific IgG antibody production.

Animals↗
PubMed1983

Immediate reconstruction using a scalp-forehead flap for the entire upper lip defect with the application of lyophilized porcine skin to surgical wounds. A case report of a malignant melanoma in the upper lip and oral mucosa.

A rare extensive malignant melanoma involving the upper lip and maxillary alveolar mucosa was removed by en bloc resection after chemotherapy and radiotherapy. Simultaneous immediate reconstruction of the entire upper lip defect was carried out with a bitemporal pedicle flap which included the scalp and forehead after applying lyophilized porcine skin to the wound where the alveolar bone had been resected, and the bilateral scalp-forehead and thigh donor sites. A partial denture was inserted six months postoperatively. Now, one and a half years after operation, the patient is quite satisfied with his cosmetic appearance and masticatory recovery.

Adult↗
PubMed1983

[Echocardiography of ischemic heart disease simulating dilated cardiomyopathy, with special reference to abnormal wall movement on the short-axis].

The purpose of this study was to determine whether two-dimensional echocardiography (2DE) can differentiate ischemic myocardial disease (IMD) from dilated cardiomyopathy (DCM). The subjects consisted of six cases of IMD which showed left ventricular dilatation (LVDd greater than or equal to 60 mm) and diffuse abnormality of wall motion, but did not show obvious localized myocardial infarction or left ventricular aneurysm on 2DE, and 16 cases of DCM. Two cases of IMD had previous myocardial infarction, and five cases of DCM had cardiomegaly following myocarditis. A short-axis image of the left ventricle was recorded at the chordal and the papillary muscle levels. Each image was divided into 4 segments, which were comprised of the septum, anterior wall, lateral (posterolateral) wall, and posterior (posteromedial) wall. Regional wall motion abnormality with reference to systolic thickening was analyzed qualitatively in each segment. The results were as follows: In ECG findings in IMD group, only one case showed abnormal Q waves and five cases showed left ventricular hypertrophy (LVH) similar to intraventricular conduction defect. On the other hand, in DCM group seven cases showed abnormal Q waves and five cases showed LVH. Two cases of IMD had two-vessel disease and four three-vessel disease, respectively. Left ventricular ejection fraction by cine-angiography ranged from 0.10 to 0.39 (mean 0.24) in IMD group and from 0.22 to 0.42 (mean 0.36) in DCM group. Mean LVDd showed no significant difference between these two groups. Five cases of DCM showed marked left ventricular dilatation (LVDd greater than or equal to 75 mm), but there were no such cases in IMD group. B-B' step was recognized in only one case of IMD, though it was present in eight cases in DCM. In regional wall motion, incidence of asynergy such as akinesis or dyskinesis was higher in IMD group than in DCM group. Left ventricular asynergy was more serious in the posteromedial wall than the posterolateral wall at the same image in five cases of IMD. However, in 12 cases of DCM, the degree of asynergy was equal at the both walls. In conclusion, it is recommended to examine echocardiographically the extent of severe asynergy in the posteromedial and posterolateral walls in order to differentiate IMD from DCM.

Adolescent↗
PubMed1983

[Clinical experience with cefpiramide in pediatrics].

Clinical effects of cefpiramide (CPM) on 10 respiratory tract infections were excellent in 9 and poor in 1, and those on 3 urinary tract infections were excellent in 3. Although CPM is considered to be excreted mainly into bile, it was suggested that the excretion rate of CPM at doses of 10 approximately 20 mg/kg into urine is good enough. Antibacterial activity of CPM was considered to be almost the same as that of cefmetazole and cefoperazone. As to side effects, weak diarrhea was observed in 2 cases. This should be considered when CPM is given to children because of its main excretion route to bile duct.

Adolescent↗
PubMed1982

WDHA syndrome caused by VIP-producing ganglioneuroblastoma.

A 3 yr 11 mo-old girl showing classical symptoms of WDHA syndrome was transferred to our department of surgery. In preoperative examination, serum vasoactive intestinal peptide (VIP) was markedly elevated and pancreatic tumor was suspected. However, no tumor was found in the resected pancreas. Unfortunately, an unexpected adrenal tumor (ganglioneuroblastoma) was found in autopsy. The tumor was judged VIPO positive, immunohistochemically. This case was thought to be WDHA syndrome caused by VIPO-producing ganglioneuroblastoma (VIPoma).

Adenoma, Islet Cell↗
PubMed1982

Regulation of the murine IgE antibody response. III. Analysis of the IgE response to insulin species variants.

IgE responses to insulin species variants i.e. to bovine, ovine and porcine insulins (respectively BI, OI and PI), were investigated. H-2d mice developed an anti-BI IgE response when this antigen was administered i.p. with A1(OH)3 gel, and H-2b and H-2a,d,k mice generated anti-BI and anti-OI IgE responses, respectively, when these antigens were injected i.p. with Freund's complete adjuvant (FCA). H-2d mice, on the other hand, developed only weak to negligible anti-PI IgE responses, when this antigen was administered in A1(OH)3 or in FCA. Antibody cross-reactivity indicated that at least two populations of IgE antibodies were produced in response to BI and/or OI; one population specific for the A chain loop and a second population specific for a determinant common to several insulins. Finally, i.v. injections of conjugates of insulin with spleen lymphocytes markedly suppressed the capacity of mice to develop an anti-insulin IgE response.

Animals↗