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Biomedical subjects

K Korth

Publications and source records attributed to K Korth.

At least 19 recordsLinked to original sources
PubMed1999

Cross-talk between the signal pathways for pathogen-induced systemic acquired resistance and grazing-induced insect resistance.

Reducing phenylpropanoid biosynthesis in transgenic tobacco compromises systemic acquired resistance (SAR) to tobacco mosaic virus, while increasing phenylpropanoid biosynthesis enhances SAR. Surprisingly, transgenic tobacco plants compromised in SAR exhibit more effective grazing-induced systemic resistance to larvae of Heliothis virescens, whereas induced insect resistance is compromised in transgenic plants with elevated phenylpropanoid levels. Levels of the phenylpropanoid-derived signal salicylic acid are directly correlated with overall phenylpropanoid biosynthesis in this series of transgenic plants. Moreover, while pathogen-induced SAR is almost completely compromised in salicylic acid-deficient plants expressing the bacterial nahG salicylate hydroxylase gene, these plants show enhanced grazing-induced insect resistance compared to wild-type. Hence, suppression of grazing-induced insect resistance is mediated at least in part by salicylic acid and likely reflects salicylic acid inhibition of the synthesis and action of the wound signal jasmonic acid. We propose that the dual functions of salicylic acid contribute to a signal poise which constrains constitutive expression of disease and insect resistance mechanisms, and reciprocally switches their selective activation.

Animals↗
PubMed1997

Endostent: new device for ureteral strictures.

The results with the new Korth Endostent (manufactured by Rüsch), which was placed in 71 ureters after endopyelotomy, were compared with the results of conventional stenting in 183 ureters. Good or excellent results were seen in 79% of the Endostented ureters v 73% of the conventionally stented ureters. With conventional stents, results were better in primary than in secondary stenoses, whereas the reverse was true with the Endostent. The Endostent provided superior results in patients with third-degree hydronephrosis and in those with long scars. There was a striking reduction in the risk of infection (fever) in patients having an Endostent inserted (7% v 44%). The Endostent may also be indicated for permanent implantation in patients with strictures of ureterovesical anastomoses involving neobladders or allograft kidneys.

Adolescent↗
PubMed1996

Percutaneous endopyelotomy and results: Korth technique.

Endoscopic incision of ureteral strictures has become an important component of the urologic armamentarium. Despite different techniques and stenting times applied for the procedures, the rates of long-term favorable outcomes have proved to range consistently from 72% to 89% for both secondary and primary hydronephrosis. Cold-knife incision combined with 3 weeks of stenting has been utilized at our institution from the beginning. The results have been as favorable as those from other groups. However, stenting times are the subject of controversy. In a prospective trial, a newly designed stent for internal reflux-free drainage and subcutaneous fixation was applied in 53 patients and left indwelling for 6 months. Whereas such long-term stenting using the Endostent seemed to produce less favorable overall results, stenting for 3 weeks proved sufficient in lower-grade hydronephrosis secondary to small stenotic ureteral segments. Although stenoses recurred in 12% of our cases, 90% of these recurrences could be treated endoscopically. All but two recurrences became evident within the first 6 months after stent removal. After a mean follow-up of 20.2 +/- 19.6 months, the outcomes have remained unchanged even on late reexamination.

Adolescent↗
PubMed1995

Rationale for antegrade sclerotherapy in varicoceles.

Clipping of the testicular veins in varicocele in principle follows open surgical treatment modalities such as the Palomo and Bernardi operations by disrupting venous reflux of the testicular veins. Thus, success rates of laparoscopic varicocelectomy range around 85% as well. As a less invasive means of treatment, retrograde (interventional) sclerotherapy of varicocele has produced long-term results as favorable as those of open surgical procedures. Antegrade sclerotherapy was introduced by Tauber as an equivalent, but even less invasive treatment modality, done by the urologist. We have performed antegrade sclerotherapy in more than 80 patients with left-sided primary varicocele. The procedure was done in local anesthesia via a scrotal incision and lasted between 12 and 60 min. If different treatment modalities yield similar long-term results, they must be valued according to how these outcomes are achieved. With antegrade sclerotherapy, the urologist has a modality at hand that is not only less invasive than laparoscopic varicocelectomy, but bears fewer risks for the patient, requires less personnel and costs less. Therefore, we consider laparoscopic varicocelectomy indicated only if antegrade sclerotherapy cannot be performed or has been tried twice without success. However, it may still be considered in bilateral varicoceles.

Adult↗
PubMed1993

[Mechanical pressure regulator for transurethral surgery of the bladder].

A new device is presented, rendering to constant pressure conditions during transurethral operations without need of intravesical pressure determination. Using a double sheath resectoscope the device is solely connected to the irrigation system. By backflow, intravesical pressure changes are transmitted to a membrane within the device. Irrigation is then controlled accordingly by a connected valve. In order to adapt bladder configuration to a situation ideal for performing resections, intravesical pressure can be set manually by regulating the tension of the membrane with a spring.

Cystoscopes↗
PubMed1993

[Laparoscopic surgery in urology. Problems--possibilities--perspectives].

To date, there have been few indications for laparoscopic surgery in modern urology. The operations already tried have posed a challenge because they require skills with this new technique that cannot be acquired by just performing this type of surgery, because of the few operations possible in urology. Thus, a cooperative arrangement was made with the surgical department in our hospital to form an interdisciplinary team consisting of a surgeon and a urologist; the team performed all laparoscopic surgery on a rotational base. Within a few months' time, this gave us sufficient experience with this new type of surgery to be able to perform even large urological operations laparoscopically.

Animals↗
PubMed1992

The "TUR-Catheter", a new catheter for postoperative drainage of the bladder.

A new catheter for postoperative irrigation of the bladder after operation of the prostate or bladder is introduced. Instead of 1 to 3 large holes measuring 5.5-6.5 mm by 2.5-3 mm at its tip, as in common catheters, it has 32 drainage holes, each of them measuring 1.5 mm in diameter. This type of construction still secures sufficient unhindered drainage of the bladder, even if the majority of holes is obstructed. Thus, postoperative tamponade is prevented.

Drainage↗
PubMed1991

[The "TUR catheter", a new indwelling catheter for postoperative bladder irrigation].

A new catheter has been developed for bladder drainage following operations on the prostate or bladder. Instead of having 1 to 3 large holes at the tip, as in common catheters, it has 32 drainage holes, each 1.5 mm in diameter. Thus, unhindered drainage of the bladder is guaranteed even if the majority of the holes is obstructed.

Catheters, Indwelling↗
PubMed1990

The chloroplast genome of an exsymbiotic Chlorella-like green alga.

Chloroplast DNA was isolated and cloned from Chlorella, strain N1a, exsymbiotic with Paramecium bursaria. BamHI, SalI, KpnI and Xho I restriction fragments of the DNA were assembled into a circular map. The genome consists of approximately 120 kbp of DNA, has a G/C content of 38%, and contains only a single copy of the rRNA cistron. The rRNA cistron is small, 5000-8000 bp, and the 16S and 23S gene are separated by less than 2000 bp.

Chlorella↗
PubMed1990

Transcription and sequence studies of a 4.3-kbp fragment from a ds-DNA eukaryotic algal virus.

A 4.3-kbp portion of the genome from the Chlorella virus, PBCV-1, has been cloned and sequenced. Minimally, five open reading frames (ORFs) were identified on this fragment. Transcriptional analysis indicates that each ORF encodes complex patterns of RNA. The total length of transcribed RNA exceeds that of the ORF indicating either post-transcriptional modification or multiple transcriptional start/stop sites. The sequence TTTTTNT, previously described as the transcriptional stop site for the early genes of vaccinia virus, is also found downstream of each of our ORFs. The regions 5' to each ORF were very A + T-rich (approx 80%) but distinct promoter sequences were not unambiguously identified.

Base Sequence↗
PubMed1990

[Endourology].

Explore the source record for details and available documents.

Endoscopes↗
PubMed1990

[Long-term results following percutaneous reanastomosis of complete ureteral occlusion].

The combination of percutaneous access to the kidney with ureterorenoscopy makes reanastomization of completely occluded ureters possible. The method has proved primising in cases where excessive previous surgery means that reintervention at the same site can be expected to be difficult. Up to now, 20 patients with complete ureteral occlusion have been successfully operated upon by endoscopic means, and 11 of them have been followed-up for more than 6 months (av. 26.1 +/- 13.4 months). In all these patients, the reanastomized ureter has remained patent.

Adult↗
PubMed1990

[Long-term results following percutaneous pyeloplasty].

Since 1982, 201 patients have undergone percutaneous incision for congenital or secondary obstruction of the pyeloureteral junction, and 171 of them have now been followed up for up to 63.3 months (12.5 +/- 11.5 months on average). All preoperative data, such as clinical and laboratory findings and results of i.v. urography and isotope nephrography, were usually controlled 6 months postoperatively. Depending on the degree of preoperative hydronephrosis, we found good and very good results in 78% of the patients followed up. Results were better in patients who had had primary stenoses, and younger patients had better outcomes than older ones. The treatment turned out during follow-up to be more successful for short stenoses than for longer ones. When pelvic or high ureteral stones were present the long-term results were less good. There were 16 patients with recurrences of obstruction, 15 of whom underwent another, this time successful, percutaneous pyeloplasty. Only 1 patient required open plastic surgery after three unsuccessful attempts at endoscopic surgery. We conclude that percutaneous pyeloplasty as we perform it is a safe endoscopic procedure that can produce reproducibly good long-term results comparable to those of open plastic surgery for primary pyeloureteral obstruction. In the case of secondary stenoses, however, a percutaneous approach should always be tried first, if in any way possible.

Adolescent↗
PubMed1989

[Pressure constant, transurethral resection with the new suprapubic "overflow regulator"].

A new suprapubic device that regulates the intravesical pressure automatically during TUR is introduced. This flow controller ensures a constantly low intravesical pressure during TUR. The irrigation fluid constantly flows over into a small open glass jar adjusted to the trocar immediately above the abdominal wall. In this way the pressure is determined by the height of the jar above the bladder, which makes it independent of the irrigation flow. Having constant low pressure conditions between 14 and 18 cm H2O, the bladder wall does not collapse. Thus, the anatomical situation does not change throughout the entire operation, which leads to markedly better overall vision.

Cystoscopes↗
PubMed1988

Percutaneous pyeloplasty.

The indication for and the technique of the percutaneous operation on strictures at the ureteropelvic junction are reported on 120 patients. The results of evaluation of 66 followed-up cases are presented. The new method proves to be superior to open surgery in secondary (acquired) stenoses with a success rate of 89 per cent, whereas in congenital stenosis the success rate was 75 per cent. However, if this simple and safe technique does fail, open plastic surgery still can be performed.

Anesthesia, Local↗
PubMed1988

Percutaneous reanastomosis of transplant kidney.

A successful percutaneous reanastomosis of a transplanted kidney is reported. The kidney already had been operated on several times. The kidney-ureter anastomosis was occluded. Using a combination of ureteroscopy and the percutaneous technique, the old anastomosis was bypassed, and a new one was made.

Adult↗
PubMed1988

Unusual applications of ureteroscopy.

Six cases of combined percutaneous and ureteroscopic opening or reanastomosis of completely occluded ureters are described. All patients had previously had nephrostomy tubes inserted to salvage their kidneys.

Adult↗