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Biomedical subjects

K Konrad

Publications and source records attributed to K Konrad.

At least 109 records · Page 6Linked to original sources
PubMed1979

Ultrastructural localization of immunoglobulin and fibrin in lichen planus.

To demonstrate the exact localization of immunoglobulin and fibrin deposits in skin lesions of lichen planus, we employed the peroxidase-antiperoxidase technique, both light and electron microscopically. IgM is shown to be deposited preferentially in and on the cytoid bodies all over their cut surface in a typical stippled pattern, partly obscuring the characteristic fibrillar substructure. All other structures such as the basal lamina are devoid of IgM deposits. Fibrin (F) is also present in cytoid bodies but in a lesser amount; it is characteristically deposited on and along the basal lamina and its reduplications in the uppermost strata of the dermis. Our results indicate that IgM deposition in cytoid bodies occurs at a very early stage during the formation of these structures and that fibrinogen exhibits a specific affinity not only to cytoid bodies but also to basal lamina material.

Fibrin↗
PubMed1979

Juvenile dermatitis herpetiformis: an immunoelectron microscopic study.

Three children with persistent maculopapular and urticarial lesions and vesicles at the predilection sites of dermatitis herpetiformis (DH) were shown to exhibit typical granular, papillary IgA and C3 deposits in the tips of the dermal papillae, as demonstrated by direct immunofluorescence. By immunoelectron microscopy, the IgA deposits were associated with the microfibrils of the elastic fibres as has been described in DH of the adult. C3 deposits were scattered throughout the papillary dermis. Despite the similarity of the clinical appearance, history with regard to gluten sensitive enteropathy (GSE) varied in these three cases. In one child, the skin lesions appeared following faults in the gluten free diet on which he was kept for coeliac disease. Another child developed the skin lesions during a gluten free diet which was not strictly followed; no recurrences of gastrointestinal symptoms accompanied the eruption of DH. In the third case, no evidence for GSE in patient's history or in jejunal biopsies was present at the time of onset of DH.

Celiac Disease↗
PubMed1979

[Sézary syndrome. Clinical, immunological and proliferative kinetics].

The development of Sézary syndrome was observed in a patient with mycosis fungoides. The Sézary cells in the peripheral blood were identified as a specific T-cell population with helper cell characteristics. Autoradiographic analysis showed that the Sézary cells obtained from skin biopsies proliferated much more rapidly than those from the peripheral blood. After transformation into a highly malignant T-cell lymphoma (immunoblastic) it came to an abrupt and fatal course of the disease.

Aged↗
PubMed1979

[Immunopathology of Duhring's dermatitis herpetiformis].

Dermatitis herpetiformis and gluten-sensitive enteropathy and their mutual association are discussed. Clinical, histopathological, immunopathological and genetic findings are emphasized, particularly with regard to the pathogenesis and diagnosis of both disorders.

Antigen-Antibody Complex↗
PubMed1979

[Ultrastructure of tumor-stroma junction of invasive laryngeal carcinoma (author's transl)].

The tumor-stroma junction of invasive squamous cell carcinoma of the larynx was examined electron microscopically. Polymorphic cytoplasmic protrusions (blebs) with a diameter ranging from 2--4 micron to 8--10 micron were observed on the basal and lateral surfaces of the malignant keratinocytes. A system of cytoplasmic 6--8 nm microfilaments can be seen consistently at the base of the blebs. The microfilaments possibly serve as a contractile ring during the pinching-off process of the blebs from the malignant keratinocytes. The blebs were observed at various stages of development until the pinching-off process occurred. They have varying shapes, sizes, and electron density and are plasmamembrane bounded. They contain hyaline ectoplasm, ribosome particles, a fine filamentous and fine granular material as well as some lysosomes. The blebbing phenomenon is discussed in respect to the cellular locomotion of malignant keratinocytes and interpreted as a possible temporary invasion mechanism in the preliminary stages of the tumor growth.

Carcinoma, Squamous Cell↗
PubMed1978

Non-inflammatory dermal elastolysis.

A 33-year-old woman is described who suffers from an idiopathic loss of mid-dermal elastic tissue which leads to wrinkling of the skin and to discrete perifollicular protrusions. In accordance with Sheley & Wood (1977) we conclude that these findings represent a new entity for which we propose the term 'non-inflammatory dermal elastolysis'.

Adult↗
PubMed1978

Immunoelectron microscopy of skin in lupus erythematosus.

A multistep immunocytochemical method, utilizing horeradish peroxidase as an immunological bound marker enzyme, was employed to demonstrate in vivo fixed immunoglobulins (IgG, IgM) in the skin of three patients with CDLE and three patients with SLE. The immunoglobulin deposits were confined to the uppermost strata of the dermis, i.e. the area just below the basal lamina. Small amounts of immunoglobulin were visible within the lamina lucida and the basal lamina. Only quantitative differences were observed between deposits of immunoglobulins in CDLE and SLE. I CDLE, the reaction product covered a wider area of the superficial dermis and extended deeper down into the dermis. IgG and IgM deposits exhibited an identical fine structural morphology.

Complement C3↗
PubMed1978

[Photochemotherapy in mycosis fungoides].

Nineteen patients with mycosis fungoides (m.f.), without involvement of lymph nodes and/or internal organs, were treated with oral photochemotherapy (PUVA). After four to five weeks of PUVA therapy (four irradiations/week) complete remission of erythematous and infiltrative plaques occurred; tumorous m.f. lesions also responded to treatment but required longer treatment times. After complete resolution of m.f. lesions the patients were controlled regularly, the observation periods ranging from 6 to 27 months. When recurrences occurred the initial treatment schedule was resumed. Recurrences, more often seen in the tumorous m.f. stage, responded to PUVA equally well as the initial lesions. PUVA therapy of m.f. is thus more effective than conventional UVB-irradiation and less problematic than treatment with cytotoxic agents or ionizing radiation. Present experience indicates that PUVA represents the treatment of choice in early stage m.f.

Adult↗
PubMed1978

[Kaposi's sarcoma. Pharyngo-laryngeal manifestation, treatment (author's transl)].

Kaposi's sarcoma involvement of the ENT region develops normally years after the onset in the skin. Reports on Kaposi's sarcoma in the ENT literature are therefore very rare. Until now by no kind of treatment including X-ray irradiation satisfactory results could be obtained. The recently introduced longterm-treatment with vinblastine sulfate is very effective reducing the size and extension of the tumorous infiltrations. In the ENT-region the plate, the pharynx, the larynx and the trachea are most frequently involved. We report on a patient with extensive pharyngeal and laryngeal involvement who had to be tracheotomized. While still on treatment with vinblastine-sulfate the decanulement was possible, the patient could resume his profession as bassoonist. This successful treatment regimen has not been mentioned in the ENT-literature previously.

Humans↗
PubMed1978

Systemic lupus erythematosus with multiple myeloma.

A 44-year-old white man presented with an erythemato-squamous rash in the supra-orbital and preauricular regions of the face. The diagnosis systemic lupus erythematosus was confirmed by histopathology, immunofluorescence (circulating antinuclear antibodies and a positive lupus band test), and by immunoelectron microscopy. Further examinations disclosed a multiple myeloma of the IgG type without cutaneous involvement. The coexistence of these two disorders has not been reported previously.

Adult↗
PubMed1977

Circulating IgA anti-basement membrane antibodies in linear dermatitis herpetiformis (Duhring): immunofluorescence and immunoelectronmicroscopic studies.

IgA deposits were observed by direct immunofluorescence in linear distribution along the basement membrane zone in a case of dermatitis herpetiformis (Duhring). In addition, in the serum of the same patient circulating IgA antibasement membrane zone antibodies were detected by indirect immunofluorescence, utilizing normal human skin and monkey esophagus as substrates. The ultrastructural localization of in vivo-bound IgA and circulating IgA antibasement membrane zone antibodies fixed to substrate tissue in vitro was found to be in the uppermost strata of the dermis below the basal lamina.

Aged↗