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Biomedical subjects

K Kohri

Publications and source records attributed to K Kohri.

At least 199 records · Page 11Linked to original sources

[A case of traumatic rupture of the testicle].

Traumatic rupture of the testicle is rare because of the protection afforded by surrounding structures. Many clinicians now speculate that this entity is underreported due to misdiagnosis. However, the condition should not be overlooked because of the importance of early treatment for the preservation of testicular function. A more aggressive approach to scrotal hematoma has been advocated. A case of traumatic rupture of testicle in a 21-year-old patient is reported. The testicle was surgically explored 6 days after trauma to the scrotum. The tunica albuginea was repaired and the testicle was preserved. Discussion is made especially on the injury to scrotum.

Adult↗

[Clinical reevaluation of aztreonam (AZT) on urinary tract infections].

The clinical effectiveness and safety of Aztreonam (AZT) were studied in 55 patients with complicated urinary tract infections. AZT was administered at a dose of 4 g/day for 5 days. The results as evaluated by the UTI criteria were excellent in 8 cases, moderate in 26 and poor in 21. The overall effectiveness rate was 61.8%. Out of 64 strains of bacteria isolated before treatment, 50 strains (78.0%) were eradicated by the treatment. Bacteriological eradication rates for gram negative rods and gram positive cocci were 79.6% and 66.7%, respectively. There were no obvious side effects, except for a temporary elevation of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase alkalinephosphatase, and total bilirubin in some patients. The results indicate that AZT tablets are useful and safe for the treatment of complicated urinary tract infections.

Adolescent↗

[Multiple myeloma in a patient with primary hyperparathyroidism].

A 50-year-old man presented with knee pain and general fatigue and was found to have severe hypercalcemia and renal failure. Hyperparathyroidism was suspected by hypercalcemia and a nodular lesion of the thyroid gland with CT-scan of the patient's neck. Exploration of the neck disclosed two slightly enlarged parathyroid glands. After surgery, the patient's serum calcium levels remained normal for two weeks, but after that his serum calcium levels rose again and renal failure continued. So needle biopsy of the kidney was enforced, and myeloma of the kidney was suspected. Multiple myeloma was diagnosed by bone marrow puncture.

Humans↗

[Staging of bladder carcinoma by magnetic resonance imaging compared with computed tomography and transurethral echography].

Various techniques are used for tumor staging of bladder carcinoma such as endoscopic photography, transurethral echography, and computed tomographic (CT) scan. Endoscopic photography enables easy observation of tumor morphology, but we utilized other approaches to determine the presence or absence of tumor infiltration. Magnetic resonance imaging (MRI) has recently found widespread use in the staging of tumors. We first employed this approach at our hospital in February 1987. We compared the diagnostic accuracy rate of MRI with that of transurethral echography and CT scan in 10 cases of bladder tumor. The diagnostic accuracy rate of MRI was 70%, while that of transurethral echography and CT scan was 40% and 50%, respectively. We concluded that MRI was very useful in the diagnostic staging of bladder tumor.

Aged↗

[Renal cell carcinoma with a long-term hemodialysis patient: a case report].

A 59-year-old man was found to have a renal cell carcinoma during about one hundred months of hemodialysis by means of an ultrasound tomography. Nephrectomy was done and renal cell carcinoma, clear cell type, with acquired renal cysts were observed, histologically. The usefulness and routine application of ultrasound tomogram are stressed for examination of the renal appearance during the management of hemodialysis.

Carcinoma, Renal Cell↗

[Percutaneous nephro-ureterolithotripsy in patients after urinary diversion or reconstruction using the intestine: report of 5 cases].

Five patients who developed urolithiasis after urinary diversion or reconstruction using the intestine were treated with percutaneous nephro-uretero lithotripsy (PNL). These patients were successfully treated, and we did not experience any severe complications. For the stone removal in this case, PNL seems to be superior to other open surgery methods.

Adult↗

The role of magnesium in calcium oxalate urolithiasis.

The aim of this study was to evaluate the effect of magnesium on calcium oxalate crystal formation, both in physiological conditions and at slightly higher oxalate concentrations, using a mixed suspension mixed product removal crystallizer and scanning electron microscopy. True supersaturation ratios were calculated by allowing for complexation in solution. Magnesium inhibited the nucleation rate at all oxalate concentrations. It also inhibited the growth rate at oxalate concentrations of less than approximately 2.0 mmol/l but promoted the growth rate at higher concentrations. This suggests that, provided the oxalate concentration is sufficiently high, increase of magnesium concentration can increase the crystal growth rate. At physiological concentrations of oxalate, however, magnesium decreases both nucleation and growth rates. The SEM photographs showed that the predominant crystal was calcium oxalate trihydrate at low magnesium concentrations, with calcium oxalate dihydrate being observed in larger quantities at high magnesium concentrations.

Calcium Oxalate↗

Treatment of vesicoureteral reflux by endoscopic injection of blood.

We have developed a new endoscopic procedure for correction of experimental and clinical reflux. It was technically feasible to correct successfully experimentally produced vesicoureteral reflux in dogs by endoscopic injection of blood. Thirteen ureters (10 patients) with grade I-III vesicoureteral reflux were treated by endoscopic injection of patient's heparinized blood behind the ureteral orifice. Before drawing out the needle, small amounts of thrombin and protamine were injected to prevent the leakage of the injected blood. Eight of thirteen treated ureters showed complete absence of reflux. The technique has both advantages and disadvantages. Advantageous points are that it is technically simple and injection can be done a few times when reflux has not disappeared. Furthermore, no complications such as distant migration of injected materials and escape from the bladder mucosa have been observed. A disadvantageous point is that the treatment has not been successful in every case.

Adolescent↗

[A case of 2,8-dihydroxyadenine stones with a partial deficiency of adenine phosphoribosyltransferase].

We report a case of 2, 8-dihydroxyadenine (2, 8-DHA) urolithiasis. A 39-year-old female was referred to our hospital with the complaint of right flank pain. An X-ray examination showed right hydronephrosis. On May 1986, right percutaneous nephrolithotripsy was performed. Infrared spectroanalysis revealed 2, 8-DHA and calcium phosphate mixed calculus. The adenine phosphoribosyltransferase activity in erythrocytes was partially deficient. Since the operation, 300 mg/day of allopurinol has been administered, and there have been no signs of recurrence.

Adenine↗

[Clinical study of extracorporeal shock wave lithotripsy].

Extracorporeal shock wave lithotripsy was performed on 81 patients with urolithiasis (35 patients with ureteral stones, 25 patients with renal stones less than 2 cm in diameter, and 21 patients with renal stones more than 2 cm in diameter) at Kanbara Hospital from August to October, 1986. A 4 Fr catheter was placed transurethrally in the ureter up to the stone to identify the stone position and the degree of fragmented stones. In four patients with staghorn calculi, a double-J catheter was placed in the ureter to prevent stone street formation. More than 50% of the patients with renal stones less than 2 cm in maximum diameter and ureteral stones had satisfactorily excreted fragments or sand of crushed stones not later than 2 weeks after the operation. However, in patients with renal stones more than 2 cm in maximum diameter, it took much more time to discharge the crushed stones compared with the foregoing two groups and some patients needed further management to remove the remnants. Combined treatment, ureteral catheterization or endoscopic operation with ESWL is recommended for treatment of renal stones larger than 2 cm in diameter.

Adult↗

[Extracorporeal shock-wave lithotripsy for children].

We performed extracorporeal shock wave lithotripsy (ESWL) on a 5-year-old and 8-year-old. Ureteral calculi in both patients were disintegrated, and all fragments were passable spontaneously. The 5-year-old girl was the youngest of the cases of ESWL reported in Japan. As this patient was 107 cm in height, we put a styrofoam layer on the back of this patient. This protected her lung from the shock wave, and the height limit was released from the ESWL treatment. These cases and the peculiarities and devices for ESWL in the pediatric field are discussed.

Child↗

Parathyroid hormone and electrolytes during long-term treatment with allopurinol and thiazide.

We have investigated the composition of plasma and urine in patients with recurrent calcium calculi treated with allopurinol alone, thiazide alone, and both agents together for more than 18 months, and compared the results with those of patients receiving no treatment. In patients treated with allopurinol, both plasma and urinary uric acid were decreased, and plasma parathyroid hormone (PTH) and urinary calcium were increased between 1 and 2 years after treatment. In patients treated with thiazide, plasma calcium was decreased 3 months after treatment but then increased gradually, although the pre-treatment level was not reached. Urinary calcium was decreased 3 months after treatment but returned to pre-treatment levels at 6 and 12 months. Plasma PTH was gradually increased. In patients treated with both allopurinol and thiazide, plasma and urinary uric acid, plasma potassium and urinary calcium were decreased during treatment. Plasma PTH increased gradually during treatment. In patients receiving no treatment, the composition of plasma and urine did not alter during follow-up. The reasons for the changes in urinary calcium and plasma PTH have been discussed.

Adult↗