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Biomedical subjects

K Kohno

Publications and source records attributed to K Kohno.

At least 487 records · Page 27Linked to original sources
PubMed1981

Aortic regurgitation with dove-coo murmur with special references to the mechanism of its generation using dual echocardiography.

Triphasic dove-coo murmur in a patient with aortic regurgitation was studied as to the mechanism of its generation using simultaneous recording phonocardiography and dual echocardiography. The murmur arose coincident with the coarse regular fluttering of aortic posterior wall during the opening of mitral valve and decreased coincident with the protrusion of mitral valve anterior leaflet into the left ventricular outflow tract. Thus the murmur might occur, provided that normal mitral valve opening and closure was maintained. It may well explain why the murmur hardly occurs in aortic regurgitation of rheumatic origin in which rheumatic lesion often is thought to involve mitral valve, restricting mitral opening during diastole and thereby inhibits aortic root vibrations.

Adult↗
PubMed1979

A case of double pylorus.

Doubling of the pyloric channel is one of the rare anomalies of the intestinal tract. There have been 23 cases of double pylorus that we have been able to find in the literature. As the etiologic aspects of double pylorus the majorities of the cases were thought to be acquired lesions from ulcer disease except three cases. We present a case of double pylorus which seems to be acquired lesion, with a review of the literature.

Aged↗
PubMed1979

An experimental study of the spread of tumor cells through the lymph node.

Intralymphatic inoculation of rat ascites hepatoma AH 130 was carried out to elucidate the function of the regional lymph node as a barrier against tumor spread. Tumor cells reaching regional lymph nodes decreased in number 48 to 72 hr after inoculation. Ten percent of tumor cells injected into lymphatic vessels appeared in the thoracic duct within 3 hr after injection. Bioassay tests revealed that transnodal tumor cells were viable in the thoracic duct.

Animals↗
PubMed1977

Pharmacokinetics and bioavailability of diltiazem (CRD-401) in dog.

Pharmacokinetic behaviour of a new coronary vasodilator, the d-cis-isomer of 3-acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride (diltiazem, CRD-401), as well as the bioavailability study of the release controlled tablet Herbesser have been described by using the proposed specific assay method of unchanged diltiazem in plasma. Quantitive analysis after its oral administration evidenced that diltiazem was absorbed through the gastrointestinal tract in the intact form. In the kinetical experiment, where diltiazem was administered i.v., a rapid and large distribution of diltiazem into tissue compartment were suggested. In the bioavailability study, a comparison of plasma concentrations of diltiazem between the two different crystals and the micronized powder resulted in no difference in their bioavailability, when they were administered in the form of capsules. In the single and multiple administration of the release controlled tablet, a slow and continuous absorption of diltiazem was observed. Elimination rate after the multiple dose regimen was in good agreement with that in a single dose, thereby indicating no accumulation in the body.

Administration, Oral↗