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Biomedical subjects

K Kitani

Publications and source records attributed to K Kitani.

At least 217 records · Page 12Linked to original sources
PubMed1978

Difference in the effect of bucolome on the hepatic transport maximum of sulfobromophthalein and indocyanine green.

The effects of bucolome (BC, 1-cyclohexyl-5-n-butyl-2,4,6-trioxoperhydropyrimidine, a non-steroid antiinflammatory agent), a potent choleretic, on the maximal biliary excretion rates (Tm) of sulfobromophthalein (BSP) and indocyanine green (ICG) were investigated in rats. With continuous infusion of BSP or ICG, Tm and bile flow rate in control rats and rats given BC (40--100 min after 20 mg/100 g body weight i.p. injection) were compared. The BSP Tm was not significantly different in control and BC administered rats (BC rats), while the bile flow rate and endogenous bile salts excretion rate were significantly higher in BC rats. On the other hand, ICG Tm was significantly higher in BC rats, although ICG concentration in bile was significantly lower in BC rats. The rates of the rise in plasma concentration of the dyes were significantly lower in BC rats. However, the plasma concentration of ICG was significantly higher in BC rats at corresponding time intervals than in control rats throughout the experimental period. The difference in the effect of BC on the transport of these two dyes indicates variability in the regulatory mechanisms for hepatic anion transport.

Animals↗
PubMed1978

Differences in the effects of secretin and glucagon on the blood circulation of unanesthetized rats.

Carbonized microspheres, 15 mu in diameter and labelled with 85Sr or 51Cr were injected into the left ventricle of unanesthetized male rats to investigate the changes induced by secretin and glucagon in the distribution of cardiac output to various organs including splanchnic organs. Secretin (0.5 U/100 g i.v.) significantly increased the cardiac output distribution to the stomach, small intestine and pancreas, while the percentage distribution of the cardiac output to the heart, lungs and kidneys was unchanged. On the other hand, glucagon (10 microgram/100 g i.v.) significantly increased the cardiac output distribution to the heart, lungs and kidneys, while the distribution to the major splanchnic organs remained unchanged with the exception of hepatic arterial perfusion which was significantly increased by glucagon.

Animals↗
PubMed1977

Bile-salt-dependent and independent choleresis induced by bucolome in the rat.

Choleresis induced by bucolome (BC) (1-cyclohexyl-5-n-butyl-2,4,6-trioxoperhydropyrimidine) was studied in male Wistar rats. [14C]Erythritol and mannitol clearance studies indicated this choleresis to be of canalicular origin. In 1-h continuous bile collection studies, immediately after the interruption of enterohepatic circulation (acute interruption), both bile flow and bile salt excretion rates were significantly increased in rats administered BC. However, the bile salt excretion rate fell rather rapidly in BC-administered rats, while the bile flow rate was fairly constant during this 1-h period. Thus, unlike the situation in control rats, bile flow rate was not significantly correlated with the bile salt excretion rate in BC-administered rats. In rats that had an external bile fistula open for 16-20 h (chronic interruption of enterohepatic circulation) the bile flow rate was also significantly increased by BC administration, while the bile salt excretion rate was not changed after BC administration. It is suggested that BC induced bile-salt-independent choleresis in both experimental rat groups (acute and chronic interruption of enterohepatic circulation). In addition, BC appeared to increase the bile-salt-dependent fraction of bile in rats with acute interruption of enterohepatic circulation, possibly by mobilizing the bile salt pooled in the intestinal content and (or) intestinal wall.

Animals↗