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Biomedical subjects

K Kihara

Publications and source records attributed to K Kihara.

At least 217 records · Page 12Linked to original sources
PubMed1984

[Clinical outcome of adult testicular tumor. I. Study on patients of nonseminoma with negative human chorionic gonadotropin].

The outcome of clinical therapy of adult nonseminomatous testis tumor presenting with negative human chorionic gonadotropin (hCG) at our hospital is reported. Of 45 nonseminoma, 28 cases showed negative hCG and they had no chorionic element. Embryonal carcinoma was found in 14 cases (50%), teratoma in 5 cases (17.9%), and teratomatous mixed tumor in 9 cases (32.1%). The 5 year actuarial survivals were 94% for stage I disease, 40% for stage II and 16.6% for stage III. Prophylactic irradiation was given to the patient with stage I disease and no relapse occurred in the irradiated area, but later, neoplasms had spread by vascular dissemination in 3 cases (17.6%). In the treatment of stage II disease, radiotherapy has proved unsatisfactory and retroperitoneal lymph nodes dissection was a choice of modality. Of 11 patients with lung metastasis including vascular dissemination from stage II and III disease, 3 cases (27.3%) were cured by localized radiotherapy and chemotherapy of the pre-VAB regimen era.

Adult↗
PubMed1984

[Clinical outcome of adult testicular tumor. II. Study on patients with positive human chorionic gonadotropin].

The outcome of clinical therapy of testis tumor presenting with positive human chorionic gonadotropin (hCG) in our hospital is reported. Of 110 patients with adult germ cell testis tumor, 19 (17.3%) had elevated hCG levels in serum or urine. Two (3.1%) of the 65 patients with seminoma and 17 (37.8%) of the 45 non-seminoma patients had positive hCG. Chorionic elements were confirmed at primary and/or metastatic sites in 10 (52.6%) of these patients, and in not a few cases different histologic features were seen at the two sites. Many patients with chorionic elements had high hCG levels (more than 3,000 mIU/ml) in serum, while patients in whom no chorionic elements were detected had low hCG levels (below 1,000 mIU/ml). The hCG-positive group seemed to have a poor prognosis because they were mostly in an advanced stage at their first visit to the hospital, and no difference in prognosis was found between the patients with chorionic elements and those without. The advanced group had a poor prognosis irrespective of their hCG levels.

Adolescent↗
PubMed1984

[A case of sclerosing lipogranuloma].

Although sclerosing lipogranuloma is relatively rare, it is of special interest to urologists because the majority of the cases occur in the genital and urinary tracts. A 49-year-old man complained of urinary frequency and lower abdominal pain. IVP examination revealed compression and irregularity of dome of bladder. CT scan showed giant abnormal mass upper dome of bladder. The tumor and part of the bladder which was adhered to it were excised. Histological findings were necrosis of the fat cells with liberation of fat droplets into the intercellular spaces. There were giant cells clinging to fatty masses and small fat vacuoles in them. Essentially sclerosing lipogranuloma is a disease affecting the fat cells which for some unknown reason undergo a degenerative type of change which results in rupture of the cells with liberation of free fat droplets into the surrounding intercellular spaces and then reaction around. Complete surgical excision is the treatment of choice. Otherwise the lesion recurs.

Granuloma↗
PubMed1984

[Chemotherapy of metastatic urothelial carcinoma. cis-Diamminedichloroplatinum combination chemotherapy for patients with decreased renal function].

Cis-diamminedichloroplatinum (CDDP) combination chemotherapy has induced a high response rate in the treatment of metastatic urothelial carcinoma at our clinic. However, due to the risks of renal failure, renal function manifested by creatinine clearance (Ccr) of more than 50 ml/min is suggested to be the requirement for CDDP therapy. Unfortunately, some patients do not meet this requirement. Thus, the renal function of patients who were treated with our combination chemotherapy was evaluated and the method of CDDP administration was modified for these patients. Four patients with Ccr in the range of 38 approximately 49 ml/min were treated and 3 patients achieved objective response; complete response in 1 case and partial response in 2 cases. Transient decrease in Ccr and elevation of blood urea nitrogen and serum creatinine were observed but these changes were reversible in all but 1 of the 10 courses. The results indicate that CDDP can be administered with reasonable safety without sacrificing anti-tumor activity in patients with Ccr of less than 50 ml/min.

Adenocarcinoma↗
PubMed1983

Utility of egg yolk medium for cultivation of Mycoplasma pneumoniae.

Chicken egg yolk broth medium containing 10% (vol/vol) phosphate-buffered saline extract of egg yolk instead of horse serum showed better growth-promoting activity for Mycoplasma pneumoniae than did Chanock medium and was effective in promoting the growth of small numbers of M. pneumoniae. Moreover, the phosphate-buffered saline extract of egg yolk proved superior to horse serum in the following respects: (i) it was consistent in growth-promoting activity for M. pneumoniae among different batches; (ii) it could be preserved at 4 degrees C for at least 2 years; (iii) it is inexpensive and easy to obtain; and (iv) it contains large amounts of lipoproteins, cholesterol, and phospholipids.

Animals↗
PubMed1983

[Treatment of pain caused by metastases of reactivated prostatic cancer with ifosfamide].

Ifosfamide (Z 4942) is an alkylating agent with the structure of a cyclophosphamide analog. Preliminary studies performed in our hospitals demonstrate the releasing effect of Ifosfamide for persistent pain caused by metastases of the prostatic cancer at various regions. Ifosfamide was given 2 grams a day intravenously with hydration and alkalization for consecutive 5 days. The regimen was performed every 3 or 4 weeks. Pain has disappeared in 7 of 10 cases within 2 or 3 courses. Pain of other 3 cases has also greatly reduced. The effective rate for the primary lesion of the prostatic carcinoma in stage C and D is 30.7%. Side effects were nausea, vomiting, hair loss and leukopenia.

Aged↗
PubMed1983

[Diagnosis and treatment of carcinoma of the prostate].

The incidence of carcinoma of the prostate has recently increased in Japan, but it is still considerably less frequent than in other countries. The highest incidence of carcinoma of the prostate occurs at around 70 years of age, and more than half of all cases are in stage C and D when detected in Japan. Antiandrogenic treatment is still widely used, but unfortunately, results are unsatisfactory in terms of control and survival rates. Other treatment modalities, for example, radical prostatectomy, radiotherapy or chemotherapy should be studied in order to improve the results. Although the results of patients with stage A and B are rather favorable, those of patients of advanced prostatic cancer are miserable. The reason is considered to be difficulty to cure large primary lesion and metastases. Development of treatment modality for stage C is therefore most important at present. In order to reduce size of primary lesion or metastatic pelvic lymph nodes estrogen should be given prior to operation or radiotherapy. Improvement of chemotherapy for the prostatic cancer will provide better results.

Adenocarcinoma↗
PubMed1982

[Chemotherapy of metastatic urothelial carcinoma].

Six patients with metastatic urothelial carcinoma--4 transitional cell carcinomas and 2 adenocarcinomas--were treated with cis-platinum (CDDP), adriamycin (ADM) and 5-fluorouracil (5-FU). CDDP (12-15 mg/m2) and 5-FU (300 mg/m2) were given on day 1-5 and ADM (30 mg/m2) was given on day 1. Courses were repeated every 3-4 weeks. In 4 cases of transitional cell carcinoma, 1 complete remission and 3 partial remissions, were obtained, but in 2 cases of adenocarcinoma, only symptomatic improvement was observed. General toxic effects consisted of vomiting, alopecia, myelosuppression and disturbance of renal function, but the therapy was well tolerated. Our encouraging results to date seemed to indicate the higher degree of effectiveness of this combination chemotherapy against the chemoresistant disease.

Adenocarcinoma↗
PubMed1981

Radiation therapy for carcinoma of the prostate.

The results of megavoltage radiotherapy by linear accelerator for the prostatic cancer are reported. Most of the patients were treated with combined radiation and hormone therapy. Five-year survival rates in stages B, C, and D were 91.7%, 58.9%, and 25.3%, respectively. Patients with stage C disease did poorly following radiotherapy compared to stage A and B patients. Improvement of overall status and atrophy of prostatic lesions was more frequently observed in stage B than in stage C disease. The post-therapeutic course was good in those patients in whom the prostate atrophied, and when this was combined with an absence of detectable cancer cells, the post-therapeutic course was excellent. Many patients who experienced only general improvement or no change in prostate size after irradiation experienced reactivation or developed metastasis.

Humans↗
PubMed1981

Behavior of Mycoplasma hominis in a human diploid cell culture system.

The behavior of Mycoplasma hominis in normal human embryonic lung fibroblast (HAIN-55) cell cultures was investigated. Multiplication patterns of cell-associated mycoplasmas and of extracellular mycoplasmas in the HAIN-55 cultures depended upon the size of the inoculum. This relationship did not vary with the number of days the cells had been cultured, nor with the number of HAIN-55 cell passages. The maximum mycoplasmal growth was obtained with inoculum sizes of 10(5) to 10(6) colony-forming units (CFU)/ml. The recovery of mycoplasmas decreased rapidly with inoculum size beyond 10(7) CFU/ml, and growth of the HAIN-55 cells was inhibited. Growth of the cells was also inhibited by the addition of the cytoplasmic fraction of Mycoplasma hominis.

Cell Line↗
PubMed1981

Attachment of Mycoplasma hominis and M. orale to human diploid lung fibroblasts.

The process of attachment of Mycoplasma hominis and M. orale to HAIN-55 cells, derived from normal embryonic human lung, was investigated quantitatively. The attachment reached its maximum within about 2-4 hr at 37 degrees C and increased linearly as a function of the number of organisms present in the system. The relative attachment efficiency of M. hominis was approximately 1% under our experimental conditions. Trypsin and EDTA were effective in detaching particles of M. hominis and M. orale from the surfaces of HAIN-55 cells. Therefore it was suggested that some proteinaceous substance and salt bridges might be involved in the attachment of these mycoplasmas to HAIN-55 cells.

Adhesiveness↗