[Determination of clofexamide and its metabolites in plasma by gas chromatography].
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Animals↗
Biomedical subjects
K Kigasawa
Publications and source records attributed to K Kigasawa.
[Studies on absorption, biotransformation and excretion of drug. VIII. Metabolic fate of a new analgesic and anti-inflammatory agent, 2-oxo-3-[4-(1-oxo-2-isoindolinyl)phenyl]-butanamide (OIB) in rats].
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Administration, Oral↗
[Studies on the synthesis of analgesics. LIV. Syntheses of 3-(substituted phenyl)-4-oxazolidinone and 3-(substituted phenyl)-3,4,5,6-tetrahydro-2H-1,3-oxazin-4-one derivatives as analgesics (studies on the syntheses of heterocyclic compounds. CMXXVII) (author's transl)].
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Analgesics↗
[Biopharmaceutical studies of drugs. III. Serum concentration level of o-ethoxybenzamide and N-(beta-hydroxybutyryl)-p-phenetidine after simultaneous administration to rabbit (author's transl)].
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Administration, Oral↗
[Biopharmaceutical studies of drug. IV. Studies on the improvement of dissolution properties and gastrointestinal absorption of 2-oxo-3-[4-(1-oxo-2-isoindolinyl)phenyl]butanamide (author's transl)].
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Animals↗
[Biopharmaceutical studies of drugs. V. Dissolution properties and bioavailability of ground mixtures of poorly water soluble drugs and soluble proteins (author's transl)].
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Animals↗
Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives.
A number of N-acyl and N-(alkoxycarbonyl)-5-fluorouracil derivatives possessing, for example, benzoyl, o-toluyl, acetyl, propionyl, heptanoyl, ethoxycarbonyl, phenoxycarbonyl, and benzyloxycarbonyl groups as N1 and/or N3 substituents were synthesized, and their antitumor activities were evaluated. The synthesis was achieved by a direct and two-step acylation of 5-fluorouracil and by selective N1-deacetylation of N1-acetyl-N3-substituted-5-fluorouracil under appropriate reaction conditions. Several N3-benzoyl- and N3-o-toluyl-5-fluorouracil derivates and showed significant activity against experimental tumor, and N1-acetyl-N3-o-toluyl-5-fluorouracil was found to be most promising among them. Further investigation revealed 12 to retain higher activity toward various tumors, with lower toxicity and good blood level, than either 1 or FT-207, even for oral administration.
Animals↗
[Pharmaceutical studies on physical properties of solid form drugs. V. Relation between compaction pressure and strength of powder compacts (author's transl)].
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Hardness↗
[Biopharmaceutical studies of drugs. II. The competitive inhibition of pentazocine glucuronidation by salicylamide in vitro (author's transl)].
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Animals↗
[Studies on the syntheses of analgesics. LII. Synthesis of 4a-(3-substituted phenyl)-1,2-disubstituted decahydrocinnoline derivatives (studies on the syntheses of heterocyclic compounds. DCCCXLIII) (author's transl)].
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Analgesics↗
[Studies on the syntheses of analgesics. LIII. Synthesis of 3-(4-substituted phenyl)-2-oxobutanamide derivatives (studies on the syntheses of heterocyclic compounds. DCCCXLV) (author's transl)].
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Animals↗
[Studies on the syntheses of antispasmodic agent. IV. Synthesis of 2-cyclohexyl-r-2-phenyl-c- and t-4-piperidinomethyl-1,3-dioxolan methiodide (studies on the syntheses of heterocyclic compounds. DCCCXLVI) (author's transl)].
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Dioxolanes↗
[Biopharmaceutical studies of drugs. I. Effect of salicylamide on serum concentration of pentazocine after oral administration (author's transl)].
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Administration, Oral↗
[Studies on the syntheses of heterocyclic compounds. DCCLXXVI. Cyclization reaction of N-substituted mandelohydrazide with formaldehyde (author's transl)].
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Cyclization↗
[Decomposition and stabilization of drugs. XVIII. Studies on the stability of carboxylic acid esters of phenol and their effectiveness as prodrug (author's transl)].
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Acetaminophen↗
[Pharmaceutical studies on physical properties of solid form drugs. IV. Behavior of powders in tabletting (author's transl)].
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Chemical Phenomena↗
[Synthesis of 6-substituted 1,2,3,4,4a,10b-hexahydro-6H-dibenzo]b,d]pyran derivatives (studies on the syntheses of heterocyclic compounds. DCCXCV) (author's transl)].
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Benzopyrans↗
[Studies on the syntheses of analgesics. XLIX. Synthesis of 2-(6-methoxy-2-naphthyl)propanoic acid (studies on the syntheses of heterocyclic compounds. DCCXL) (author's transl)].
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Animals↗