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Biomedical subjects

K Kigasawa

Publications and source records attributed to K Kigasawa.

At least 37 records · Page 2Linked to original sources
PubMed1990

Urinary surge of human luteinizing hormone in infertile women.

An improved semiquantitative immunoassay method allows human luteinizing hormone (hLH) in urine to be detected from 2.5 to 640 mIU/ml has developed. With this method, the hLH surges in every 3 h urine samples while awake were measured in 8 normal and 12 infertile women. The result was that the urinary hLH surge in infertility was insufficient regardless of the high urinary E2 value. This result may play, at least in part, an etiologic role in infertility.

Adult↗
PubMed1987

Clinical features of a newly recognized type of lattice corneal dystrophy.

We examined five patients with an undescribed type of lattice corneal dystrophy. All patients were in the seventh to ninth decades of life and had developed decreasing vision late in life. None of the patients had suffered from recurrent epithelial erosions, there was no overt evidence of systemic amyloidosis, and the lattice lines were much thicker than those usually observed in lattice corneal dystrophy types I and II. Available pedigree data from two families of three patients indicated that the corneal disorder affected several siblings but not the parents or offspring. Two patients had no affected family members. There was no known consanguinity in any of the four families.

Adult↗
PubMed1987

Histopathologic and immunochemical features of lattice corneal dystrophy type III.

We examined seven corneas from five patients with a new form of lattice corneal dystrophy (designated lattice corneal dystrophy type III) by light and electron microscopy. Numerous amyloid deposits were scattered throughout the corneal stroma, some of which were much larger than those usually observed in either lattice corneal dystrophy type I or II; these were located predominantly midway between the epithelium and the endothelium. Image analysis disclosed that the cross-sectional size of the large stromal amyloid deposits was significantly greater than those in age-matched patients with lattice corneal dystrophy type I. All patients had a discontinuous band of amyloid (15 to 25 micron wide) in the superficial stroma beneath Bowman's layer, which usually had only one or two small disruptions. Descemet's membrane and the endothelium were normal. The stromal deposits, which were composed of 10-nm diameter fibrils typical of amyloid, stained positively with Congo red after the histologic sections were pretreated with dilute potassium permanganate. Immunohistochemical studies on formalin-fixed, paraffin-embedded tissue indicated that only some deposits reacted weakly with antibodies to amyloid protein AA. The deposits stained positively with antibodies to protein AP and negatively with antibodies to kappa and lambda immunoglobulin light chains.

Amyloid↗
PubMed1986

Primary band-shaped spheroidal degeneration of the cornea: three cases from two consanguineous families.

Three cases of primary band-shaped spheroidal degeneration of the cornea from two consanguineous families are reported. In all cases vision deteriorated slowly, the deterioration beginning in childhood. Photophobia in childhood was also a common symptom, and two patients suffered from intermittent painful sensations. The occupational and environmental histories had no bearing on the cases. Histochemical study of the yellow, oily appearing deposits suggested that this material has a complex composition, with staining characteristics of both protein and acid-fast lipid.

Adult↗
PubMed1985

Erythrocyte filterability and adenosine triphosphate levels in normal pregnancy and puerperium.

The filterability of erythrocytes was determined by a filtration method using erythrocytes suspended either in phosphate-buffered saline or in native plasma. Erythrocytes from pregnant women in the second and third trimester were significantly less filterable than those from non-pregnant women. On 0 to 1 day after delivery, erythrocyte filterability was further reduced, being significantly lower than that in the third trimester of pregnancy. Erythrocyte adenosine triphosphate (ATP) levels during pregnancy were not significantly different but in early puerperal period it was significantly lower than that in non-pregnant women. One month after delivery the filterability and ATP content of erythrocytes returned to the non-pregnant levels. The size and hemoglobin concentration of erythrocytes were unchanged during pregnancy and puerperium.

Adenosine Triphosphate↗
PubMed1984

A method for monitoring ADP-induced thromboembolism in mice.

A method for monitoring ADP-induced thromboembolism in mice by means of the measurement of respiratory rate and depth was studied. The measurement were accurately carried out with a new method devised by us. In mice intravenously injected with 5-40 mg ADP/kg, it was found that the respiratory rate decreased transiently and dose-responsively, and that the platelet count also decreased transiently. On the other hand, no decrease in respiratory rate after administration of ADP was observed in neuraminidase-pretreated mice, in which the platelet count was significantly reduced. In the histological examination, platelet thrombi formed in the pulmonary vessels were observed 10 sec after administration of 10 and 40 mg/kg of ADP in mice which had not been treated with neuraminidase. The extent of thromboembolism at the dose of 40 mg/kg showed a tendency to be more marked than that at 10 mg/kg. Pretreatment with 300 mg dipyridamole/kg p.o. prevented the respiratory depression at 40 mg ADP/kg. However, with 10 mg dimorpholamine/kg i.v. or 30 mg warfarin/kg p.o., no preventive effect was observed. Therefore, it was concluded that it is possible to monitor ADP-induced thromboembolism in mice by means of the accurate measurement of the respiratory rate and depth.

Adenosine Diphosphate↗
PubMed1984

A new method for measuring respiration in the conscious mouse.

A highly sensitive apparatus and method for measuring respiratory changes in conscious mice and rats is described. The apparatus is constructed from readily available components and consists of three sections: 1) mouse housing capsule and respiratory-sensitive part; 2) air supplying part; and 3) data recording part. Changes in the respiration of an encapsuled mouse can be accurately detected by means of changes in pressure exerted on the respiratory-sensitive part attached to the capsule. In our study, the rapid increases and decreases in the respiratory rates of these animals after the i.v. administration of respiratory depressing agents (morphine and arachidonate) and a respiratory stimulant (dimorpholamine) were recorded with exceptional accuracy by this procedure.

Animals↗