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Biomedical subjects

K Kakudo

Publications and source records attributed to K Kakudo.

At least 145 records · Page 8Linked to original sources
PubMed1982

Medullary carcinoma of the thyroid with ectopic ACTH syndrome.

An autopsied patient with medullary carcinoma of the thyroid and ectopic ACTH syndrome is reported. A microadenoma of pancreatic islet coexisted in this case, which is assumed to be of D cell origin. Immunohistochemical study revealed decreased number of pituitary ACTH cells. Some of them showed Crooke's degeneration. Hormone assay study of tumor tissue and plasma disclosed abnormal ACTH, beta-MSH as well as calcitonin. Somatostatin and Substance P were also demonstrated in tissue. Histologically the tumor showed solid alveolar pattern with a minor part consisting of small cell variant and this histologic variation is discussed.

ACTH Syndrome, Ectopic↗
PubMed1981

[Experimental teratoma derived from mouse yolk sac (author's transl)].

By using no carcinogens, well differentiated teratomas were induced by BALB/c nu/+, +/+ and ICR strain of mice. On the 11th to 18th day of gestation, mice were laparotomized and all fetuses were removed from uterus, leaving placentas in situ and fetal membranes were protruded into peritoneal cavity. After 5 to 139 days of operation, extrauterine tumors developed in twenty five mice of fifty fetectomized mice. In BALB/c nu/+ mice the tumor developed in six of ten, in +/+ mice eighteen of twenty five and in ICR mice only one of fifteen. The tumors were all histologically well differentiated teratomas, some contained tissues derived from one germ layer and other from two or three germ layers but no undifferentiated cells. The teratomas became cystic, so we call, endodermal cysts on histological examination during rather long term observations. We concluded that these induced tumors were not genuine tumors in real pathologic means but only well differentiated tissues derived from the yolk sac on developmental stage. Alpha-fetoprotein (AFP) in serum or in cystic contents of the tumor bearing mice were not detected by double immunodiffusion method.

Animals↗
PubMed1980

Hypoglycemia in a child with hepatoblastoma.

A five-year-old boy with hepatoblastoma, who showed a severe hypoglycemia as an initial symptom, was studied. After resection of tumors, hypoglycemia disappeared and did not recur despite recurrence of tumor. A high concentration of insulin-like activity (ILA) was found in preoperative serum and in the tumor extract. Hypoglycemia in this patient seemed to depend mainly on ILA and in part on liver enzyme activities related to carbohydrate metabolism.

Carcinoma, Hepatocellular↗
PubMed1980

Watery diarrhoea with a vasoactive intestinal peptide-producing ganglioneuroblastoma.

An 8-month-old boy with persistent watery diarrhoea and failure to thrive developed abdominal distension, hypokalaemia, and flushing of the face and trunk. A high concentration of vasoactive intestinal peptide-like immunoreactivity was found in the serum. Soon after resection of a suprarenal mass, the serum level of vasoactive intestinal peptide became normal and the diarrhoea stopped. Histologically the tumour was a ganglioneuroblastoma: the cells showed fluorescence by the indirect immunofluorescence technique with anti-vasoactive intestinal peptide serum. Electron microscopical examination showed abundant secretory granules in the tumour cells. Reports of chronic watery diarrhoea in children due to neural crest tumours are reviewed, with particular respect to the clinical features of the syndrome.

Abdominal Neoplasms↗
PubMed1979

C cell carcinoma of the thyroid--papillary type.

Two cases of papillary type of C cell carcinoma of the thyroid were reported. They showed papillary arrangement with fibrovascular stalk in properly fixed tissues. Histochemically argyrophil reaction was positive in the cytoplasm and amyloid deposited in the stroma. Ultrastructurally secretory granules were found in their cytoplasm. The papillary type is not an artifact but one of the histologic variations of this carcinoma.

Adult↗
PubMed1978

Medullary carcinoma of the thyroid. Giant cell type.

This report presents a rare histological variation of medullary (C-cell) carcinoma of the thyroid, referred to as giant cell type, which is similar to that found in anaplastic carcinoma of the thyroid, or choriocarcinoma. The giant cells in this case possessed specific immunofluorescence for calcitonin and secretory granules in the cytoplasm. The giant cells were tumor cells of medullary carcinoma and could be distinguished from anaplastic carcinoma of the thyroid by various histological characteristics, such as nuclear invagination, an intermingled pattern of giant cells with typical small solid cells, infrequency of mitosis, and the existence of amyloid stroma.

Carcinoma↗
PubMed1977

Ultrastructural study of thyroid medullary carcinoma.

This study deals with 11 cases of thyroid medullary carcinoma of which 7 were familial cases including 3 cases of Sipple's syndrome and 4 cases of sporadic cases. There were also 2 cases of Cushing's syndrome. In addition to the previously described English literatures about human medullary carcinoma of the thyroid, the rod-shaped body with cristae and an abundant glycogen particles in the cytoplasm, nuclear inclusion bodies of cytoplasmic invagination and microvilli at the surface membrane of gland formation were found in our cases. The mean and mode diameters of secretory granules of all familial cases with only calcitonin secretion were larger than those of the sporadic cases with ectopic ACTH and beta-MSH in addition to calcitonin secretion. Ultrastructural study on non-cancerous follicles of grossly normal thyroid of two cases of early familial medullary carcinoma disclosed apparently increased C-cells which were not intrathyroidal metastases. It is supposed that the increased C-cells in the thyroid of the familial cases are multicentric C-cell hyperplasia.

Adrenocorticotropic Hormone↗
PubMed1977

Experimental rat choriocarcinoma: an electron microscopic study.

Experimental choriocarcinomas of the rat were studied with electron microscopy and compared with the ultrastructure of rat trophoblasts at mid-and late-gestational stage. The choriocarcinoma numbered m-803 contained abundant cytoplasmic organellae and was quite similar to the trophospongial cell at late-gestational stage. The M-801 closely resembled the trophospongial cell at mid-gestational stage. The m-673, which has 3-beta-ol dehydrogenase enzyme system, could not be studied sufficiently inspite of the examination of more than 30 blocks of epon embedded specimen, because of the degeneration and necrosis occurring in the specimens.

Animals↗