Biomedical subjects
K K Datta
Publications and source records attributed to K K Datta.
Toxicological studies of a leachable stabilizer di-n-butyltin dilaurate(DBTL): effects on hepatic drug metabolizing enzyme activities.
Toxicological studies of a leachable stabilizer Di-n-butyltin dilaurate (DBTL) were undertaken. Effects of DBTL after 15 days oral exposure to rats were studied on brain and liver enzyme activities. A significant decrease in body weight gain of DBTL exposed rats were observed. No effect was observed in the activities of brain enzymes, succinic dehydrogenase, adenosine triphosphatase, acetylcholine esterase and monoamine oxidase. In liver, DBTL treatment resulted in a significant decrease in the activities of microsomal enzymes glucose-6-phosphatase, aminopyrine-N-demethylase, benzphetamine-N-demethylase, aniline hydroxylase, benzo(a)pyrene hydroxylase and also on cytochrome P-450 content, whereas no difference in the activities of mitochondrial enzymes, succinic dehydrogenase, Mg2+-adenosine triphosphatase as well as in the activity of lysosomal enzyme acid phosphatase was observed. Duration of exposure dependent increase in pentabarbital induced sleeping time was also observed. DBTL treatment produced an induction in heme oxygenase activity whereas the activity of -aminolevulinic acid synthetase remained unaltered. The results demonstrate that DBTL significantly affects the biotransformation mechanism and heme metabolism of hepatocytes.
Prevalence of intestinal parasites in urban area of Alwar, Rajasthan.
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Morbidity due to common communicable diseases in rural India.--An institutional study.
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Response of female guinea pigs to repeated oral administration of quinalphos.
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Weak estrogenic activity of lindane in rats.
Administration of lindane (20 mg/kg . d) for 30 d to ovariectomized rats caused no significant change in the weight of the uterus, cervix, or vagina. Histological changes in these organs were comparable to those in ovariectomized control rats. Treatment with estradiol dipropionate alone and in combination with lindane induced a significant increase in the weights of these organs. Microscopically, these organs appeared normal. Lindane induced a significant increase in the glycogen content of the uterus, cervix, and vagina of ovariectomized rats compared to ovariectomized control rats, whereas a two- to fourfold increase in glycogen was observed in ovariectomized rats treated with estradiol dipropionate or estradiol dipropionate plus lindane. There was a significant increase in total erythrocytes and hemoglobin in ovariectomized rats treated with lindane, estradiol dipropionate, or lindane plus estradiol dipropionate. An increase in neutrophils with a corresponding decrease in lymphocytes was also observed in rats treated with lindane or lindane plus estradiol dipropionate.
Response of carbon tetrachloride treated male rats to benzene hexachloride & Quinalphos.
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Epidemiological studies on bancroftian filariasis in East Godavari district (Andhra Pradesh): baseline filariometric indices.
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Interaction of phosphamidon & benzene in female rabbits.
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Surveillance of cholera at Alwar, Rajasthan.
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Effect of methyl demeton on vital organs & cholinesterase in male rats.
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Morbidity and mortality in infants in a rural community of Rajasthan--a prospective cohort study.
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Toxicological studies of ammonium sulfamate in rat after repeated oral administration.
A 90-day study involving administration of O (group 1), 100 (group 2), 250 (group 3) and 500 mg/kg (group 4) of ammonium sulfamate to rats 6 days a week was carried out. No adverse effect was observed in respect of appearance, behaviour or survival of animals. No significant difference in the body weights of rats was observed except in case of adult rats (group 4) where the body weight was significantly less than the controls after the end of 60 days. In all the groups food intake gradually reduced whereas water intake increased as the experiment proceeded. No significant change in relative organ weights were noticed in all groups of rats. Haematological examination conducted at 30, 60 and 90 days revealed non-significant increase in the neutrophils in the adults and male weanling rats (group 4) after 90 days. In the histological examination, organs in all the groups of animals appeared normal except that the liver of 1 rat in adults (group 4) showed slight fatty degenerative changes after 90 days.
Effects of paraquat dichloride in male rabbits.
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Endosulfan: lack of cytogenetic effects in male rats.
Cytogenetic effects of endosulfan (Thiodan) a member of the chlorinated hydrocarbon insecticide was tested in male albino rats. The insecticide was administered orally to rats at 0, 11.00, 22.00, 36.60 and 55.00 mg/kg daily for 5 days. The highest doses were associated with clinical signs of insecticide poisoning and death. Cytogenetic analysis of bone marrow cells and spermatogenial cells did not reveal any significant effect of the insecticides on chromosomes. The ratio of mitotic index and frequency of chromatid break in the two cell types had no correlation with the doses tested and was not very different from those of the control group.
Comparative response of male rats to parathion and lindane: histopathological and biochemical studies.
Exposure of male rats to parathion (2.6 mg/kg), lindane (17.6 mg/kg), or their combination through oral intubation daily for a period of 90 days produced histological and biochemical alterations in the liver and testis. The focal necrosis of the liver, although observed in all the treatments, was very prominent in the animals exposed to lindane alone. The kidney and epididymis, however, did not show any significant histological lesions. The activity of acetylcholine esterase in blood and brain decreased markedly, whereas that of succinic dehydrogenase, adenosine triphosphatase, and the alkaline and acid phosphate in liver and testis showed significant alterations for all three treatments.
Histopathological and biochemical changes in guinea pigs after repeated dermal exposure to benzene hexachloride.
Dermal application of benzene hexachloride in daily doses of 100, 200 and 500 mg/kg for a total period of 30 days caused significant changes in male guinea pigs. The animals exposed to high doses of benzene hexachloride (1,2,3,4,5,6-hexachlorocyclohexane) (BHC) (BHC) died within 5--12 days. There was no mortality in 100 mg/kg/day but significant pathologic and biochemical changes were observed in the vital organs of the experimental animals. Massive congestion and thickened blood vessels were seen in liver of the BHC treated animals in comparison to the normal picture of the controls. Similarly, testicular changes included mild to severe pathologic lesions. There was no change in the epididymis, kidney, spleen, brain and lungs. The changes in the skin were mild and no signs of dermatitis were observed in the BHC painted areas. The activity of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) and alkaline phosphatase in liver and serum revealed significant changes from that of the controls. The significance of biochemical changes with the tissue damage of the insecticide exposed animals are discussed.