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Biomedical subjects

K Jonsson

Publications and source records attributed to K Jonsson.

At least 145 records · Page 8Linked to original sources

Late mortality and morbidity after arterial reconstruction: the influence of arteriosclerosis in popliteal artery trifurcation.

Mortality and the incidence of myocardial infarction and cerebrovascular lesion have been retrospectively analyzed in patients who have survived 30 days after lower limb vascular reconstruction. These events have been related to the extent of arteriosclerotic lesions in the trifurcation of the popliteal artery (trifurcational disease, TFD) in 368 patients treated consecutively. One hundred fifty-five patients underwent aortoiliac reconstruction, 229 had femorodistal bypass, and 16 underwent both procedures. The median follow-up period was 4.4 years. The mortality rate in male and female patients was increased compared with the expected mortality. This increase was found both in patients with and without TFD. In patients having TFD the mortality was 2.0 times higher than in patients who did not have TFD (p less than 0.001). The difference in the mortality rate persisted after correction for the influence of age, sex, and diabetes mellitus. The higher mortality rate in patients who had TFD was most marked early in the postoperative period and was mainly caused by myocardial infarction. The incidence of myocardial infarction and cerebrovascular events was significantly increased in patients who had TFD compared with those who did not, particularly in the early postoperative period.

Adult↗

Angiography in colonic carcinoma.

Angiography of the mesenteric arteries was performed in 17 patients with adenocarcinoma of the colon and rectum. At angiography, the marginal artery was encased in 13 patients and 10 of these were surgically unresectable while three could be resected radically. Encasement of the mesenteric arterial branches was found in seven of 11 unresectable tumors and in two of five resectable tumors. The resectability of colonic carcinoma cannot be established by means of angiography but in two patients with recurrent colonic carcinoma, barium-enema examinations were negative, while infiltrated vessels were demonstrated by angiography and the carcinomas were verified at surgery. Four patients received intra-arterial chemotherapy with mitomycin C. In one of these, a slight decrease in tumor size was noted, while in the others no change was noted.

Adenocarcinoma↗

Width of the normal ankle joint.

An investigation of the talocrural joint was performed in 160 normal adults, 80 males and 80 females. The joint space was measured on films at six locations, three in the antero-posterior and three in the lateral view of the ankle. The average joint space in men was 3.4 mm and in women 2.9 mm, which is a significant difference (p less than 0.001). The joint space was wider in the medial part when evaluating the antero-posterior view, but did not change with age.

Adolescent↗

Effect of ioxaglate on the liver and pancreas following selective visceral angiography in man.

Selective visceral angiography was performed with the ionic, monoacidic, dimeric contrast medium ioxaglate (280 and 320 mg I/ml). Twenty patients with and without disease of the liver and/or pancreas were prospectively and consecutively studied. Changes in the serum activities of ALAT, ASAT, GT, AP, and pancreatic isoamylase and changes in the level of serum bilirubin, prothrombin index and haematocrit were evaluated sequentially before and after angiography. The total volume of contrast medium ranged from 100 to 340 ml per patient and the median dosage was 3.5 ml per kg body weight. There was no statistically significant elevation within the entire group of patients in the measured parameters after angiography when compared with pre-angiographic values. No clinically important toxic effect on the liver or pancreas induced by the contrast medium was found.

Abdomen↗

Percutaneous transluminal angioplasty of arteriosclerotic lesions in the pelvis and lower extremities.

The experience of percutaneous transluminal angioplasty (PTA) in 66 patients (71 stenoses) with arteriosclerotic lesions in the pelvic and lower extremity arteries is reported. The PTA was technically successful in 70 stenoses. Complications were seen in eleven patients. The follow-up time was 19 months (2-44). The frequency of recurrencies was clearly related to the location of stenosis, the more distal the lesion the higher the recurrency rate. The immediate roentgenologic result had no prognostic value to protect recurrencies. To conclude PTA is an alternative to surgery in patients with short stenoses in the iliac arteries, but very strict indications should be used when lesions are localized below the inguinal ligament.

Adult↗

Arteriosclerosis in popliteal artery trifurcation as a predictor for myocardial infarction after arterial reconstructive operation.

The frequency of myocardial infarction and mortality within 30 days after lower limb vascular reconstruction, in relation to the extent of atherosclerotic lesions in the trifurcation of the popliteal artery, have been retrospectively analyzed in 158 consecutive patients reconstructed in the aortoiliac region and 239 consecutive patients undergoing femorodistal bypass. Among the patients without trifurcational disease (TFD) none had myocardial infarction develop postoperatively, as compared with four of the 50 patients with TFD in the aortoiliac series (p less than 0.05) and 18 of the 174 patients with TFD in the femorodistal series (p less than 0.05). In nine instances, the cause of death was myocardial infarction. The strong correlation between postoperative myocardial infarction and the presence of TFD, may be due to a direct correlation between coronary artery disease and TFD. The finding is of practical importance in the selection of treatment for patients with circulatory disorders of the lower limbs. The finding facilitates the preoperative identification of patients liable to have myocardial infarction develop. Indications for operation can be made more stringent and optimal intraoperative and postoperative monitoring can be instituted.

Acute Kidney Injury↗

Aneurysms of the popliteal artery.

A retrospective study of 13 patients with 18 popliteal artery aneurysms has been undertaken. The patients were seen under a period of 12 years. Six of the patients had extrapopliteal aneurysms as well. Seven of the popliteal aneurysms presented as vascular emergencies, due to occlusion of the popliteal artery. In this group the amputation rate was 57%. In the elective group no amputation was necessary nor did any patient suffer from claudication during follow-up. Ultrasonography is a good tool for demonstrating the nature of the disease. Usually a short exclusion bypass is enough to reconstruct the area. A popliteal aneurysm, if not occluded and asymptomatic, is an indication to operate because of the threat to the limb in case of embolism or thrombosis.

Adult↗

Radiologic evaluation of subdiaphragmatic spread of Hodgkin's disease.

A prospective investigation is presented on the usefulness of lymphography, computed tomography, ultrasound, radionuclide examinations and fine-needle aspiration biopsy of the spleen and the liver in assessing subdiaphragmatic spread of Hodgkin's disease. Initial staging laparotomy is superior to all other diagnostic procedures. If laparotomy cannot be performed, CT and scintigraphy of the spleen are recommended. At restaging CT and lymphography provide equal diagnostic yield; CT is suggested, however, to be used in the first place.

Adolescent↗

Development of carpal bone cysts as revealed by radiography.

In 11 patients with carpal bone cysts the course of the intraosseous lytic lesion could be followed over periods from 2 to 27 years. The cysts were found to develop from an area of sparse trabeculae of reduced mineral content to a well-defined cavity, in some instances surrounded by a sclerotic zone. In 2 instances the lytic process caused progressive destruction of the subchondral layers of the affected bone resulting in communication with the adjacent joint space. The findings support the theory that carpal bone cysts are intraosseous lesions probably caused by vascular disturbances from mechanical stress and repeated trauma. The term intraosseous ganglion is a misnomer and should be avoided.

Adult↗

Arthrosis of the lunate-capitate joint.

Arthrosis of the lunate-capitate (LC) joint was investigated in 44 wrists from 36 patients. The symptomatology was uncharacteristic and most patients were examined because of pain, swelling or decreased function of the wrist. The LC arthrosis seemed to be secondary to trauma in most patients; 26 wrists had an increased distance between the lunate and scaphoid, indicating a rotatory luxation of the scaphoid; 5 had fracture of the scaphoid with pseudarthrosis; one had a radius fracture healed with volar and ulnar compression and 2 had penetrating trauma to the LC joint. The arthrosis was secondary to pathologic changes in the lunate in 3 patients; lunatomalacia in 2 and a cyst fracturing into the LC joint in one. In 7 wrists arthrosis was found in several carpal joints and the LC arthrosis was one of these.

Adult↗

Median nerve compression complicating arthrodesis of the rheumatoid wrist.

The frequency and pathogenesis of median nerve compression complicating the Rush pin method of fusing the rheumatoid wrist was evaluated retrospectively. This complication was encountered in 14/50 wrists (28%). In 7 hands the carpal tunnel was explored, mostly within 2 weeks after fusion. In addition to signs of acute entrapment of the median nerve the most constant finding was that the volar edge of the resected distal end of the radius was prominent and projected into the bottom of the carpal tunnel caused by too vigorous correction of the subluxed carpus. Obviously the median nerve was squeezed or angulated at the volar edge of the radius. After median nerve release and resection of the bony prominence all patients regained full sensibility within the period of observation (in average 2.5 years). It is concluded that this mechanism of nerve entrapment should be realized when fusion of a severely destructed rheumatoid wrist is considered.

Arthritis, Rheumatoid↗

Renal failure as a complication to aortoiliac and iliac reconstructive surgery.

A retrospective analysis has been undertaken of 17 patients among 221 who developed renal failure after aortic and/or iliac reconstructions because of occlusive disease (incidence 8%). In two renal artery occlusion was causing anuria, in the others tubular necrosis was considered to be responsible. This complication is multifactorial and factors of importance may be: operative trauma, haemorrhagic and other postoperative complications with reoperations, age and preoperative angiography. The patients with postoperative renal failure were older, the preoperative serum creatinine slightly higher, operation time longer and intraoperative haemorrhage greater than in patients without postoperative renal failure. Renal insufficiency after aorto-iliac reconstruction is a symptom with poor prognosis, the mortality being significantly higher (35%) than among the 204 patients without renal failure (2.0%). No simple dominating risk factor has been found in this material.

Adult↗