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Biomedical subjects

K Jonsson

Publications and source records attributed to K Jonsson.

At least 181 records · Page 10Linked to original sources

Angiographic work-up in a patient with late vaginal metastasis from a renal carcinoma.

Vaginal metastasis from a renal cell carcinoma appeared 23 years after the primary surgery in a 64-year-old female. At angiographic work-up local recurrence in the renal fossa and liver metastasis were demonstrated. These findings indicated radiation treatment instead of radical surgery of the vaginal metastasis, which primarily was though to be solitary. Angiography and/or computorized tomography (CT) of the retroperitoneal space and the liver should be performed in patients with late and presumed solitary metastasis from a renal cell carcinoma before radical surgery of the metastasis is attempted.

Adenocarcinoma↗

Mitomycin C in advanced gallbladder carcinoma.

Seven patients with advanced gallbladder carcinoma were given intraarterial infusions of 10 to 15 mg mitomycin C with 10 to 24 days' interval, 3 received intravenous infusion (10 mg/m2) with median 3 weeks' interval. Stationary disease was obtained in 4 patients, progressive disease in 4, and treatment failures in 2. The median survival after mitomycin C treatment was 4 months (range 1-23 +). Irreversible thrombocytopenia occurred in 2 patients and a severe gastrointestinal bleeding episode in one.

Aged↗

Short-term intra-arterial mitomycin C in hepatic metastases.

Short-term intra-arterial Mitomycin C treatment of hepatic metastases from various malignancies was performed in 24 evaluable patients. An objective regression was obtained in 12 patients. The median survival of responders was 11 months compared with 3 months in nonresponders. No complication of the technical procedure occurred and the treatment was well tolerated. The only side effect of clinical importance was thrombocytopenia, which occurred at a median dose of 45 mg of Mitomycin C.

Adult↗

Carpal bone cysts: a clinical and radiographic study.

In order to analyse and correlate the clinical and radiographic features of intracarpal bone cysts a review of 80 cysts in 77 patients is presented. Some cysts were found to develop very slowly from an area of trabecular fading to a well-defined cavity, bordered by a zone of radiopacity. Pain was constantly correlated to cysts with marginal sclerosis and at operation these cysts were found to be made up of fibrous tissue with mucoid changes. Most cysts were located in the scaphoid and lunate which are known to have vulnerable vascular supplies. These bones are also exposed to heavy load during power grip. It is, therefore, plausible that these cysts are caused by intramedullary vascular disturbances, followed by bone resorption and fibroblastic proliferation, and that pain is elicited by increasing pressure inside the cyst.

Adolescent↗

Arterial occlusion of pelvic bone tumors.

Arterial occlusion of the internal iliac artery was successful in the relief of pain due to primary and secondary neoplasms of the bony pelvis in 8 of 9 patients. These included 3 giant cell tumors, 1 aneurysmal bone cyst, 1 recurrent chondrosarcoma, 3 metastatic renal cell carcinoma and 1 metastatic clear cell sarcoma. Calcification of the margin of the lesion occurred in 3 of 4 primary neoplasms after infarction. The transcatheter arterial occlusion was accomplished utilizing Gelfoam and stainless steel coils. Although most patients experienced pain and fever for several days following the procedure, no permanent sequelae or complications were encountered.

Adenocarcinoma↗

How accurate is angiographic staging of renal carcinoma?

Angiographic interpretations were compared with the pathologic findings of 75 patients undergoing nephrectomy for renal carcinoma. Angiography correctly predicted the clinical stage in only 36 per cent of the cases. This failure rate was attributed to the lack of consistent radiologic criteria for determining invasion of the perinephric fat, renal vein, and extension to regional lymph nodes.

Adult↗

Angiography in leiomyosarcoma of the inferior vena cava--report of two cases.

Two patients with leiomyosarcoma of the suprarenal inferior vena cava are presented. In one case the tumour was misinterpreted as intrahepatic at angiography. In the second case an extrahepatic location was suggested after repeated angiography. The diagnosis should be borne in mind when a large hypovascular mass appears to be located centrally in the liver at coeliac angiography and when ultrasound examination has revealed its solid nature.

Age Factors↗

Lymphangiography in patients with malignancy in a non-descended testicle.

Lymphangiography was performed on 23 patients with malignancy in non-descended testicles, 14 of whom had seminomatous and 9 non-seminomatous tumors. Lymph node metastases were shown by lymphangiography in 8 patients: 3 in lumbar nodes, 1 in iliac nodes alone and 4 in lumbar and iliac lymph nodes. Microscopic metastases were shown in lumbar nodes at retroperitoneal lymph node dissection in 2 patients when the lymphangiograms were negative. Iliac lymph node metastases are rare in testicular tumors but may be seen in tumors of non-descended testicles, alone or in combination with lumbar metastatic disease. This information is extremely important for the radiologist as well as the clinician in the management of patients.

Adult↗

Prostaglandin E1 (PGE1) in angiography of tumors of the extremities.

Prostaglandin E1 (PGE1) is a potent vasodilator. The value of this agent as an adjuvant in angiography of tumors of the extremities was evaluated in 10 patients. Except in one case involving a hemangioma, the diagnostic information concerning tumor vascularity and delineation of the extent of disease decreased after the use of PGE1. The visualization of small normal muscular arteries was improved. Therefore, the effect of PGE1 may be to preferentially increase the blood flow in normal tissues relative to the tumor. PGE1 seems to be of little value in enhancing the angiographic demonstration of neoplasms of the extremity.

Adolescent↗

Angiography of abdominal leiomyosarcoma.

The spectrum of angiographic findings of abdominal leiomyosarcoma in 33 cases is presented, and the value of angiography in the diagnosis and management of such patients is discussed. Angiographic features of abdominal leiomyosarcomas are different depending upon the site of origin. Small bowel lesions are hypervascular, and those in the stomach and colon moderately vascular. Well circumscribed masses with enlarged feeding arteries and draining veins form the predominant presentation of small bowel leiomyosarcoma. In the retroperitoneum these neoplasms are usually hypovascular to moderately vascular, and displacement of major vessels, particularly the inferior vena cava, is the most common angiographic finding. Bladder leiomyosarcoma can be either moderately vascular or hypervascular. Vascularity of metastases is usually similar to that of the primary lesion.

Abdominal Neoplasms↗

Lymphangiographic changes after radiation therapy.

Lymphangiographic appearance following radiotherapy is described in 21 patients with pre- and posttherapy lymphangiograms. Following radiotherapy to normal lymphatics, decrease in nodal size and lymph vessel caliber is noted uniformly after 12 months. Before 12 months the development of these changes is variable and may not be seen, especially during the first several months. Following irradiation of abnormal lymph nodes, dilatation of the lymph vessels distal to the abnormal nodes may occur. These lymphangiographic findings can be related to histologic changes seen in lymph nodes after radiation therapy.

Adolescent↗

How is renal carcinoma detected?

The primary symptoms and signs, indicating urography, in 369 patients with renal carcinoma have been reviewed. Gross haematuria was noted in 33%, signs of malignancy in 20% and in 13% metastases were first diagnosed. In 15% the renal tumor was an incidental finding at urography performed because of prostatism, cystopyelitis, hypertension and prostatic carcinoma. It is concluded that every urography must have such a high quality as to be able to evaluate the entire urinary system in all patients, as a renal carcinoma may be found at urography in any patient above the age of 30 years.

Abdomen↗

Changes in the lymphatic dynamics after retroperitoneal lymph node dissection.

Lymphatic dynamics in the retroperitoneal space are altered after retroperitoneal lymph node dissection. Obstruction with or without visible collaterals is seen frequently. Lymphaticovenous communications and lymphocysts are also common findings. The immediate sequelae are of minor importance, although the mass effect of lymphocysts may be serious. The collateral pathways and lymphaticovenous anastomoses may result in the appearance of metastases in unusual sites.

Adolescent↗

The angiographic appearance of thymic tumors.

Angiography of the internal mammary artery was performed in 30 patients with suspected tumors in the anterior mediastinum. In 3 patients, thymic venography was also performed. In 13 lymphoepithelial thymomas, a smooth outline with the arteries penetrating the periphery of the tumor was demonstrated. Frequently, neovascularity but never encasement of large arteries or arteriovenous (AV) shunting was exhibited. In the lymphoepithelial thymomas of the cell-rich type, the accumulation of contrast medium and neovascularity were pronounced. This type of thymoma may possibly be locally more invasive than others. In carcinomas, the arteries penetrated the tumor and AV shunting was common. Arteriography was superior to venography in the few patients in whom both examinations were performed. Angiographically, it should be possible to differentiate thymomas from carcinomas.

Adult↗

Fine needle aspiration biopsy of retroperitoneal lymph nodes and abdominal masses: an updated report.

Percutaneous fine needle aspiration biopsy of retroperitoneal lymph nodes and abdominal masses was performed in 109 patients. Eighty-five per cent of the aspiration biopsies yielded sufficient cytologic material for a correct diagnosis. Indications include confirmation of lymphangiographic findings and the establishment of a histologic diagnosis in lieu of surgery. No significant complications were encountered.

Abdominal Neoplasms↗

The use of prostaglandin E1 for enhanced visualization of the splanchnic circulation.

A single bolus injection of prostaglandin E1 (5-7.5 microgram) into the superior mesenteric, hepatic or pancreatico-duodenal arteries was employed as a pharmacoangiographic aid in 22 patients. Good quality arterial phase and greatly enhanced portal venograms were obtained. No significant complications were observed. The authors found the technique useful in diagnosis of primary and metastatic lesions in the liver and pancreas.

Abdomen↗