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Biomedical subjects

K Jensen

Publications and source records attributed to K Jensen.

At least 217 records · Page 12Linked to original sources
PubMed1990

[Indomethacin in severe cerebral contusions with intracranial hypertension].

In five head-injured patients with cerebral contusion and oedema in whom it was not possible to control ICP by hyperventilation and barbiturate sedation, indomethacin Confortid was used as a cerebral vasoconstrictor drug. In all patients indomethacin reduced ICP below 20 mmHg for several hours. Studies of cerebral circulation and metabolism during indomethacin treatment showed a decrease in cerebral blood flow (CBF) at 2 hours. After 7 hours. ICP remained below 20 mmHg in three patients, and these still had reduced CBF. In two patients a return of ICP and CBF to pretreatment levels was observed. In all patients indomethacin treatment was followed by a fall in rectal temperature. Outcome scaling has not yet been performed, but all patients left hospital without neurological deficits. These results suggest that indomethacin is an alternative in the treatment of intracranial hypertension in head-injured patients.

Adult↗
PubMed1989

[Traditional and alternative treatment of patients with multiple sclerosis].

The medicine consumption and the employment of alternative treatment were investigated in a material of 117 patients with disseminated sclerosis (DS) considered to be a representative sample of the patients with DS in the County of Funen. This investigation revealed that the preparations most commonly employed to modify the disease among patients with disseminated sclerosis were: spasmolytics, agents to counteract neurogenic bladder symptoms, benzodiazepine and analgesics. The consumption of medicine increased with increasing handicap. Employment of psychopharmaca was commonest in patients in social classes 4 and 5 and in women. In addition, is was found that there was no difference in social class, sex and age among the patients who employ alternative methods of treatment. The patients themselves have not experienced any effect from alternative treatment.

Adult↗
PubMed1989

[Pregnancy and disseminated sclerosis. A retrospective study].

A retrospective investigation was undertaken on 64 female patients with disseminated sclerosis (DS) on the Island of Funen. The object was to investigate whether pregnancy and delivery influenced the course of the disease. The results were standardized for the age of commencement and the duration of the disease. In addition, the available literature on the subject is reviewed. It was found that the group of women in whom the disease commenced before or in connection with pregnancy or delivery had more severe physical handicaps than women without children or in whom the disease commenced after the last delivery. Women in whom the disease commenced in connection with the last delivery were most severely handicapped. In women in whom the disease commenced more than six months after the last delivery, the long term prognosis is not poorer than for women without children.

Female↗
PubMed1989

Mesenteric venous infarction in acute pancreatitis.

Segmental intestinal necrosis is a rare complication of acute pancreatitis. The pathogenesis of intestinal necrosis in acute pancreatitis has previously been attributed to arterial thrombosis, but we have observed an unusual case of segmental small intestinal infarction associated with pancreatitis that could not be explained by this mechanism. In our patient, the clinical, gross, and microscopic features were compatible with mesenteric venous infarction. A search of the literature revealed three previous cases of small intestinal infarction in patients with acute pancreatitis with similar clinical and histologic findings. Mesenteric venous infarction of the colon has also been described in association with acute pancreatitis. It seems clear that mesenteric venous infarction represents an additional cause of intestinal necrosis in patients with acute pancreatitis, and may result from changes in clotting mechanisms known to be induced by acute pancreatitis.

Acute Disease↗
PubMed1989

Existence of similar antigenic-sites on varicella-zoster virus gpI and gpIV.

We previously identified the antibody-binding site of a monoclonal antibody (mAb 79.0) on varicella-zoster virus (VZV) glycoprotein I (gpI) and showed that this monoclonal antibody binds to both VZV gpI and gpIV (Vafai et al., J. Virol. 62, 2544, 1988). In this study, a synthetic peptide comprising the mAb 79.0 binding site (designated el) was prepared and anti-peptide antibodies (RAnti-el) were raised in rabbit. RAnti-el recognized the primary translation products encoded by VZV genes 67 (gpIV) and 68 (gpI). To further localize the binding site of RAnti-el on VZV gpIV, the gpIV gene cloned in pGEM transcription vector was cleaved at different locations to generate four truncated DNA fragments. RNA was transcribed from each truncated gpIV fragment, translated in vitro and immunoprecipitated with RAnti-el. The results indicated that RAnti-el binds an antigenic determinant within the first 153 amino acid residues on the primary translation product of VZV gpIV. In addition, RAnti-el recognized the high-mannose intermediate but not the mature from of gpI in the infected cells or the translation products of gpIV glycosylated in vitro in the presence of canine microsomal membrane. These results: (a) confirmed the existence of a shared antigenic determinant on both VZV gpI and gpIV; and (b) indicated that the addition of terminal sugar modification may influence the conformation of gpI and gpIV with respect to the antigenic determinant recognized by RAnti-el.

Antigens, Viral↗
PubMed1989

Pressure pain thresholds and thermal nociceptive thresholds in chronic tension-type headache.

The nociceptive thresholds to mechanical and thermal stimuli in patients with chronic tension-type headache were compared. Palpation of pericranial tenderness was performed in 50 patients and a total tenderness score (TTS) was calculated. Palpation was repeated, and pressure pain thresholds (PPTs) were determined with a pressure algometer in the temporal and occipital regions. In 32 of the patients, pain thresholds for heat and cold and limens for detection of non-painful temperature changes were determined in the hands and the temporal regions. Twenty-four healthy volunteers served as controls. Scores obtained by manual palpation (TTS) at the first and second visit were positively correlated. A negative correlation between headache severity and PPT was found in the temporal region. A positive correlation between PPT in the temporal and occipital region was found, and PPT and TTS were negatively correlated. Thermal pain thresholds were consistently less extreme in patients compared to controls, and patients reporting severe headache on the examination day were those most sensitive to thermal pain. No difference was found between patients and controls with respect to detection of temperature changes. A correlation was found between PPT and the corresponding cold pain thresholds, but no correlation could be demonstrated between TTS and thermal pain thresholds. In conclusion, headache patients had decreased pain perception thresholds. Chronic tension-type headache might be a result of dysmodulation of nociceptive impulses, but it is likely that sensitized nociceptors also play a role.

Adult↗
PubMed1989

Measurements of human pressure-pain thresholds on fingers and toes.

Pressure-pain thresholds (PPT) were measured on fingers and toes with a hand-held electronic pressure algometer in 15 males and 15 females. The pressure algometer offered easy control of pressure application rate. The intra-individual coefficient of variation, based on repeated PPT measurements with a 1 week interval was 14%. The inter-individual coefficient of variation was 28% for females and 33% for males. In the course of 10 consecutive PPT measurements with short intervals (10 and 20 sec), no significant change in PPT was observed. PPT was found to be 50% higher in males than in females (P less than 0.0001). Slightly but significantly higher PPT values were found on the dominant compared to the non-dominant side (P less than 0.005).

Adult↗
PubMed1989

Cerebral blood flow during anaesthesia: influence of pretreatment with metoprolol or captopril.

We have studied the influence of a beta adrenergic blocking agent and an angiotensin converting enzyme (ACE)-inhibitor on cerebral blood flow (CBF) during general anaesthesia before surgery. Nine patients served as controls and received no special pretreatment. Two other groups were allocated randomly to receive either metoprolol 0.07 mg kg-1 i.v. (nine patients) at the time of induction or captopril 1 mg kg-1 by mouth (11 patients) 1.5 h before induction. There was no significant difference in CBF or CBF values corrected for changes in PaCO2 (CBF corr.) between the metoprolol group and controls. In the group pretreated with captopril, CBF corr. values were significantly lower compared with the metoprolol group. Low CBF corr. in association with low mean arterial pressure was observed in two patients treated with captopril. These findings suggest that treatment with ACE-inhibitors should be discontinued before anaesthesia.

Adult↗
PubMed1989

Evaluation of eccentric exercise in treatment of patellar tendinitis.

The purpose of this study was to analyze the effects of a quadriceps femoris muscle eccentric training program on strength gain in patients with patellar tendinitis. The effect of an eight-week eccentric exercise program on quadriceps femoris muscle work was evaluated in four groups of subjects--two groups of "normal" (healthy) subjects and two groups of patients with patellar tendinitis. All four groups participated in a home muscle stretching exercise program, but only two groups--one group of normal subjects (N-A) and one group of subjects with tendinitis (T-A)--received additional eccentric training on an eccentric isokinetic dynamometer. The eccentric quadriceps femoris muscle work ratio (involved limb/uninvolved limb x 100) was used to quantify strength in the N-A and T-A Groups. Pain ratings were recorded for subjects with tendinitis before and after the eight-week experiment and were correlated with the dependent variable using a Spearman rank-order correlation coefficient. The N-A Group performed significantly better than all subjects with tendinitis (p less than .05). Subjects in the T-A Group, however, showed a trend toward increasing eccentric quadriceps femoris muscle work capacity over the eight-week training period. As pain ratings in the T-A Group increased, work ratios decreased. We concluded that eccentric exercise may be an effective treatment for patellar tendinitis, but that knee pain may limit optimal gains in strength.

Adult↗
PubMed1988

Multiple sclerosis: correlation of psychiatric admissions to onset of initial symptoms.

Forty-two (12%) of a total of 366 patients with multiple sclerosis (MS) had psychiatric admissions. Of these, 34 (81%) had their first psychiatric admission in conjunction with or after the onset of MS. Classification by psychiatric diagnosis showed that there was a significant positive correlation between the onset of MS and the first psychiatric admission for psychoses and transient situational disorders, but not for neuroses.

Hospitalization↗
PubMed1988

Critical roles of spo0A and spo0H in vegetative alkaline phosphatase production in Bacillus subtilis.

Growth conditions established to optimize vegetative alkaline phosphatase production and stability in Bacillus subtilis were used to compare alkaline phosphatase synthesis and secretion in isogenic strains JH646 (spo0A12) and JH646MS (spo0A12 abrB15). A mutation in spo0A blocked vegetative alkaline phosphatase production, and a second mutation at the abrB locus resulted in hyperinduction of vegetative alkaline phosphatase. Phosphate regulation of vegetative alkaline phosphatase synthesis was unaffected in the double mutant. spo0H, on a multicopy plasmid, partially overcame the spo0A effect.

Alkaline Phosphatase↗
PubMed1988

Hypovolemic stimuli and vasopressin secretion in man.

Different non-hypotensive hypovolemic stimuli were applied to 21 healthy and 20 uremic dialysis patients. The purpose was to study the effect on plasma arginine-vasopressin concentration, using orthostasis as a reference model. Orthostasis increased the plasma AVP level in healthy subjects as well as in uremic dialysis patients. In healthy subjects plasma AVP increased both when they were normohydrated and after they had been water-depleted. Lower body negative pressure (LBNP, -40 mmHg) was applied to 11 healthy males to induce a central blood volume decrease, equal to that induced by orthostasis. The plasma AVP increased in two subjects only who became hypotensive during the investigations. Ten hemodialysis patients were volume-depleted by isolated ultrafiltration. A flow directed Swan-Ganz catheter was used to measure the central intravascular pressures. Pulmonary capillary wedge pressure was reduced to normal or subnormal values during 1-2 h of ultrafiltration, without any significant changes in plasma AVP. Plasma AVP increased only in 2 patients, who became hypotensive during the investigations. Thus, of the present non-hypotensive volume stimuli only orthostasis was able to stimulate AVP secretion. Equal or even greater reductions in central blood volumes by other stimuli had no effect on AVP secretion. The results demonstrate that isolated stimulation of low-pressure volume receptors has no effect on the secretion of AVP in humans.

Adult↗