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Biomedical subjects

K Jensen

Publications and source records attributed to K Jensen.

At least 199 records · Page 11Linked to original sources
PubMed1991

Acute and chronic pain syndromes in multiple sclerosis.

A representative sample of 117 patients with definite multiple sclerosis (MS) was interviewed on pain syndromes. Chronic syndromes lasting more than one month included dysaestesthesia, low back pain, spasms, tonic seizures, tightening and painful sensations in the extremities. Acute syndromes included neuralgia, L'Hermitte's sign and pain associated with optic neuritis. Thirty-five per cent were pain-free. Of the remaining patients had 45% pain at the time of the examination, 32% indicated pain among the most severe symptoms of MS and 23% had pain at the onset of MS. The number of patients with pain at the time of the examination increased with age and duration of disease. Patients with pain were significantly more often spastic and significantly more often sought alternative treatment forms. No difference was found for mean age, sex, physical impairment, duration of disease from onset of MS, depressive score and score of delayed verbal memory.

Acute Disease↗
PubMed1991

The 5' noncoding sequences from a less virulent Theiler's virus dramatically attenuate GDVII neurovirulence.

RNA transcripts derived from recombinant chimeras between the highly virulent GDVII virus and the less virulent BeAn virus were constructed to study the molecular pathogenesis of Theiler's murine encephalomyelitis virus infection. The presence of the BeAn 5' noncoding sequences in chimera 2 (BeAn 5' noncoding sequences joined with the GDVII nucleotides encoding the polyprotein and present in the 3' end) resulted in dramatic attenuation of GDVII neurovirulence and development of poliomyelitis in mice. This reduced neurovirulence was associated with slower virus growth and lower peak titers in the brain and spinal cord than with parental GDVII virus replication. On the other hand, the sites of replication following chimera 2 infection were the same as those seen in GDVII-infected mice; the distribution of virus antigen and histopathological changes indicated that chimera 2 replicates in neurons in the brain, e.g., in the neocortex, hippocampus, caudate putamen, and brain stem, as well as in anterior-horn cells in the spinal cord. Chimera 2 was efficiently cleared from the mouse central nervous system by day 30 postinfection, in marked contrast to the persistence of the BeAn parent in the central nervous system. This suggests that elements in the BeAn sequences that encode the polyprotein or are present in the 3' noncoding region are necessary for viral persistence. It is of interest that chimera 2-infected mice developed localized inflammatory, demyelinating lesions which were detected at day 28 postinfection but these lesions did not become larger with time. Thus, virus persistence appears to be required for maintenance and progression of immune-mediated demyelination. If the demyelinating lesions become sufficiently large, clinical signs and disease may develop.

Acute Disease↗
PubMed1991

Multiple sclerosis: the impact of physical impairment and cognitive dysfunction on social and sparetime activities.

In a cross-sectional investigation of 116 patients with multiple sclerosis, the social and sparetime activities of the patient were assessed by both patient and his/her family. The assessments were correlated to physical disability which showed that particularly those who were moderately disabled suffered from severe psychosocial strain. The literature shows that the strain becomes even more severe in certain periods of progression of the disease with the result that psychosomatic conditions arise.

Activities of Daily Living↗
PubMed1991

Fractures in multiple sclerosis.

In a cross-sectional study of 299 MS patients 22 have had fractures and of these 17 after onset of MS. The fractures most frequently involved the femoral neck and trochanter (41%). Three patients had had more than one fracture. Only 1 patient had osteoporosis. The percentage of fractures increased with increasing age and disease duration. Among 34 deceased MS patients 4 had had fractures. These findings are discussed in relation to physical and cognitive impairment in MS. A case-control study is recommended.

Adult↗
PubMed1991

Influence of feeding intensity on blood concentrations of glucose, ketone bodies and free fatty acids in nutritionally adapted dairy cows fed 24 times daily.

Concentrations of acetoacetate, D-3-hydroxybutyrate, glucose and free fatty acids were determined in blood from 3 Jersey cows during a 5-months period. The cows were fed an identical complete feed every hour, from ad libitum intake to maintenance level, for 28 days at each of the following levels of intake: 170, 138, 102, 53 and 37 g organic matter per kg bodyweight0.75 (metabolic bodyweight). Throughout the experimental period, the cows were in negative energy balance, which was reflected in an average weight loss of 640 g per day. None of the metabolites differed from reference values for healthy lactating cows. The concentration of D-3-hydroxybutyrate decreased linearly with the level of feeding and reflected a decreased ruminal production of butyrate. The high feeding frequency to lactating cows may be considered an essential factor in the prevention of ketosis.

Animals↗
PubMed1991

[Disseminated sclerosis: organic basis for mental disorders and cognitive dysfunction].

The MRI-(magnetic resonance imaging) scanner has improved the knowledge of the organic basis of cognitive defects in multiple sclerosis. Recent studies demonstrated a correlation of MRI-verified single lesions, atrophy of the corpus callosum and cognitive defects; but failed to demonstrate the convincing correlation between psychic symptoms and MRI-verified lesions.

Atrophy↗
PubMed1991

[Disseminated sclerosis: sexual and obstetrical aspects].

The onset of Multiple Sclerosis (MS) usually occurs at an early age and consequently often causes sexual problems. In the case of women, it also gives rise to doubts concerning whether or not it is justifiable to undertake pregnancy and childbirth under these circumstances. Such difficulties and doubts are described and guidelines submitted for appropriate forms of help, support and therapy which could be offered.

Adult↗
PubMed1990

Temporal muscle blood flow in chronic tension-type headache.

Temporal muscle blood flow was measured with the xenon 133 clearance technique in 40 patients with chronic tension-type headache and in 13 control subjects. Pressure-pain threshold in the temporal region was determined with an algometer. Patients and control subjects did not differ in any of the blood flow parameters. Resting blood flow at the two sides was highly correlated (Spearman coefficient, r = .61) and no right/left differences could be demonstrated. In both patients and control subjects, blood flow increased approximately fivefold during isometric work (1/3 of a maximum surface electromyogram). Reactive hyperperfusion after isometric work was found in 8 patients and in 1 control subject. There was no definite correlation between the pressure-pain threshold and the corresponding blood flow. It is not likely that temporal muscle ischemia is the cause of muscle tenderness and pain in patients with chronic tension-type headache.

Adult↗
PubMed1990

Intraoperative venous dilation and subsequent development of deep vein thrombosis in patients undergoing total hip or knee replacement.

This patient study was based on the observation of characteristic intimal lesions in jugular and femoral veins removed from dogs a few hours following total hip replacement. The lesions, small localized intimal tears, suggested that smooth muscle and connective tissue, might have dilated beyond the ability of intima to accommodate. Intraoperative venous dilation correlated with the incidence of intimal lesions. It was postulated that surgical trauma resulted in circulating vasoactive substances which caused venous dilation and that dilation of smooth muscle and connective tissue beyond the yield point of intima resulted in intimal rupture. Similar intraoperative dilation and lesions, in patients might predispose to development of deep vein thrombosis (DVT). Total hip (THR) and total knee (TKR) replacement patients were selected for study because: (a) of the high incidence of DVT and (b) blood circulation is present in THR but not in TKR patients during operation. Ultrasound was used to monitor cephalic vein diameter during the perioperative period. Development of DVT postoperatively was compared with intraoperative venous dilation. In THR patients, intraoperative venous dilation ranged from 6%-56%. One of nine patients with dilation less than or equal to 17% developed DVT while 12 patients with dilation of greater than or equal to 22% developed DVT, giving a correct prediction of 95%. Of four patients in the intermediate range (19%, 20%), two developed DVT and two did not. The sharp demarcation was to be expected because of abrupt rupture of viscoelastic material when the critical point of elongation is exceeded.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1990

Multiple sclerosis: symptom equivalent to delayed visual evoked potential latency.

An investigation on the correlation between ability to read TV subtitles and the duration of visual evoked potential (VEP) latency in 14 patients with definite multiple sclerosis (MS), indicated that VEP latency in patients unable to read the TV subtitles was significantly delayed in comparison to that of patients who mastered this task.

Adult↗
PubMed1990

Evidence for two structural genes for alkaline phosphatase in Bacillus subtilis.

Two secreted alkaline phosphatase proteins were purified from cultures of Bacillus subtilis JH646MS. The two proteins showed slight differences in subunit molecular weight, substrate specificity, and charge characteristics. A total of 62% of the first 22 amino-terminal amino acids were identical. Both sequences showed conservation of structural features identified in Escherichia coli and human alkaline phosphatases. One alkaline phosphatase was a monomer and the other was a dimer. Southern analysis of genomic DNA with degenerative oligomers based on the amino acid sequences suggest that there are two structural genes for alkaline phosphatase in the genome of B. subtilis.

Alkaline Phosphatase↗
PubMed1990

Antibiotic susceptibility and phage-type pattern of Staphylococcus aureus strains isolated from patients in general practice compared to strains from hospitalized patients.

Phage-type patterns and antibiotic susceptibility have been examined in 904 Staphylococcus aureus strains from general practice in the Copenhagen municipality, in 1107 strains from hospitals in the Copenhagen municipality and in 18,028 strains isolated in 1988 from inpatients all over Denmark. The phage-type patterns of the 3 materials were very similar except for a slightly higher frequency of group II strains among isolates from general practice (24% compared to 19%). Penicillin resistance was high (86-87%) in all materials. Resistance to tetracycline and erythromycin was more frequent in strains from general practice (8.6% and 3.8%) than in strains both from hospitals in the same area (3.6% an 2.2%) and in all Danish hospitals (5.3% and 2.4%). This indicates that the restrictive use of antibiotics in hospitals seems to have eliminated the previous preponderance of multiresistant staphylococci in hospitals compared to community acquired staphylococci. It even seems as if the less restrictive use of tetracycline and erythromycin in general practice has now inversed the situation.

Anti-Bacterial Agents↗