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Biomedical subjects

K Ichimura

Publications and source records attributed to K Ichimura.

At least 217 records · Page 12Linked to original sources
PubMed1979

[Clinical studies on PC-904 in biliary tract diseases (author's transl)].

The clinical effects of PC-904, a new semisynthetic penicillin, were studied in patients with biliary tract diseases, and the results were as follows: 1) PC-904 showed an average peak serum level of 40.7 +/- 11.6 microgram/ml 2 hours after an intravenous drip infusion of 1 g of the agent. The biliary level showed a peak value of 126.5 +/- 85.4 microgram/ml 2 hours to 3 hours after the infusion. 2) Isolated organisms from bile before the treatment were E. coli, Klebsiella, Proteus, Pseudomonas, Enterococcus and Bacteroides. MIC of PC-904 on 18 strains of isolated organisms was almost 6.25 microgram/ml or less. All isolated organisms except one strain of Klebsiella oxytoca disappeared after the treatment. 3) Six patients with cholelithiasis were medicated with PC-904 to prevent post-operative infections. The clinical effects were good in 4, poor in 1 and unknown in 1 case. 4) As to side effects no adverse reactions and allergic reactions were noted. Also no significant abnormalities of laboratory findings were observed.

Ampicillin↗
PubMed1978

Effect of chlorpromazine on the in vitro immune response.

The effect of chlorpromazine at concentrations from 10(-7) to 5 X 10(-5)M on the in vitro plaque-forming cell responses to sheep erythrocytes was tested. If CPZ was present in cultures during the whole incubation period, concentrations of CPZ more than 5 X 10(-6)M inhibited the PFC responses, whereas concentrations between 5 X 10(-7) and 5 X 10(-6)M had a slightly enhancing effect. If a defined concentration of CPZ (1.3 or 1.5 X 10(-5)M) was added to cultures for a brief period of time (12 or 24 h) at various intervals after the initiation of culture and antigenic stimulation, PFC responses were inhibited most effectively during the first brief periods of incubation. The later the drug was added, the more the extent of inhibition decreased. On the other hand, CPZ had no effect or a slightly enhancing effect when added in the very late period (72--95 h) of incubation. These findings suggest that the observed immunosuppression could be attributed mainly to the impairment of early cellular events, presumably cell interaction events, preceding the process of DNA synthesis and cell proliferation of antibody-forming cells and their precursors.

Animals↗