Concentration of three types of nitrogen in human urine.
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Biomedical subjects
Publications and source records attributed to K Ichimura.
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A two year old child presented with a history of cyclic fever since the sixth week of life, and otorrhea of six weeks' duration, unresponsive to treatment. Surgical removal of massive granulation tissue and sequestrated bone, combined with parenteral administration of pipellacillin and dibekacin successfully resolved the Pseudomonas infection. Neutropenia and the decreased chemotactic activity of neutrophils were observed in this patient. This neutrophil disorder seemed to be primary and a contributing factor.
Thirty-four chronic myringitis cases were examined by otoscopy, pure tone audiometry, tympanometry, skull X-rays, and bacteriologic study of otorrhea. Five atypical cases are presented in detail. Three of these five cases had a perforation of the tympanic membrane preceding the appearance of typical chronic myringitis. The remaining two cases showed a transient small tympanic membrane perforation during the long course of chronic myringitis. These cases suggest that chronic myringitis could occur in some chronic suppurative otitis media and that myringitis could cause tympanic membrane perforation.
The etiology of the recurrence of acute otitis media is not thoroughly understood. Recently, abnormal functions of neutrophils have been regarded as the cause of recurrent infections, and a few papers dealt with defective chemotactic responses of neutrophils in patients with recurrent otitis media. With the in-vitro agarose plate technique, neutrophil chemotaxis and random migration were measured in 20 children with recurrent otitis media to yield a significantly decreased chemotactic index compared with age-matched controls. Patients with other recurrent infections, such as recurrent parotitis and recurrent tonsillitis, showed a normal chemotactic index. Other children who had not only recurrent otitis media, but also systemic manifestations, showed an extremely low chemotactic index and revealed either defective phagocytic activity or deficiency of IgA. Defective chemotactic response may be one of the essential factors causing repeated attacks of middle ear infection.
Patients who were diagnosed as polyps or nodules of vocal cords (PN group), and two control groups were tested with Japanese version of Maudsley Personality Inventory to evaluate the personality characteristics of patients with these behavior-induced vocal cord diseases. PN group showed significantly higher E (extraversion-introversion) scores than each control group. This extraversive tendency had no relation to their age, sex, polyp or nodule, and occupation. N (neuroticism) scores were not significantly different between PN group, and each control group. L (lying) scores of PN group were significantly lower than a control group. It was suggested that extraversive personality was one of the important factors relating to the pathogenesis of vocal cord polyp and nodule.
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Although double primary malignant neoplasms of bilateral maxillary sinuses wee regraded as extremely rare, there have been 50 patients described in Japan since 1937. Among them only eight cases showed the histologic distinction between both sides. A 64-year-old man with double primary carcinomas had a mucoepidermoid carcinoma of the left maxillary sinus and a papillary adenocarcinoma of the right one with an interval of three years. He was treated with a combination of surgery, radiotherapy and regional chemotherapy. The histologic combination of these tumors could not be found so far. The advantage of this combination treatment for the carcinoma of the maxillary sinus is stressed.
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