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Biomedical subjects

K Honda

Publications and source records attributed to K Honda.

At least 721 records · Page 40Linked to original sources
PubMed1981

Red cell preservation and removal system of purine derivatives.

The new preservative containing high concentrations of adenine (8 mM), inosine (40 mM) and other chemicals which was indicated by Nakao et al., was applied to the preservation of red cell concentrates. Moreover, the system for the removal of purine derivatives (adenine, inosine and hypoxanthine) added and produced in stored samples was developed, using bead activated charcoal coated with the blood-compatible polymer (Hydron). Over 90% of purine derivatives in the medium and erythrocytes were removed by Hydron-coated bead activated charcoal (HAC) column. The recovery of erythrocytes by HAC column treatment was over 98%.

2,3-Diphosphoglycerate↗
PubMed1979

Electromyographic study of patients with dysfunction of the Eustachian tube.

In order to determine how often dysfunction of the tube might arise from dysfunction of the tubal muscles, electromyographic examination of the muscles was carried out on 34 patients with occluded or patent tube. Using a monopolar needle electrode inserted through the nose, selective EMG of the tensor and levator veli palatini muscles were picked up during swallowing. It was found that the patients showed neither abnormally reduced nor increased muscle activity. Comparison of muscle activity of the normal tube and of both the occluded and patent tube revealed no significant differences. Therefore, myogenic cause of tubal dysfunction seems improbable from the clinical viewpoint.

Electromyography↗
PubMed1979

Sodium valproate and thrombocytopenia.

Thrombocytopenia has been occasionally reported in patients on sodium valproate. Here is reported a 6-year-old boy on this drug who was found to have thrombocytopenia 6 months after initiation of administration and it was progressive up to 16 months. Though the medication was continued because of its efficacy, platelet count gradually recovered to the normal level spontaneously. Throughout the course, no hemorrhagic tendency was observed clinically. It was suggested that platelet count should be monitored periodically, but that the presence of thrombocytopenia itself does not serve as an absolute indication for discontinuing the drug.

Child↗
PubMed1979

Changes in 2,3-DPG content and oxygen affinity in erythrocytes stored at 4 degrees C.

The 2,3-DPG content of red blood cells increased within the first 24 h when fresh erythrocytes or whole blood were stored 4 degrees C. This phenomenon was strongly pH dependent. The temporary increase in 2,3-DPG was scarcely observed below pH 7.4 or above pH 7.8. In the case of whole blood, the increase was observed in CPD blood out not in ACD blood. Similar results were obtained with erythrocytes suspended in saline, when its pH was adjusted to approximately 7.6. Plasma proteins were not essential for the increase in 2,3-DPG content. Extracellular oxygen levels were continually measured in erythrocytes suspensions in order to check the changes in oxygen affinity of hemoglobin without damaging the cells. Both extracellular oxygen levels and 2,3-DPG contents were simultaneously increased by keeping fresh erythrocytes at 4 degrees C. Inhibition of glycolysis with sodium fluoride and monoidoacetic acid indicated that the in vivo steady state of glycosis in erythrocytes might be altered by chilling to make the rate of 2,3-DPG synthesis faster than that of 2,3-DPG decomposition.

Citrates↗