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Biomedical subjects

K Hirose

Publications and source records attributed to K Hirose.

At least 505 records · Page 28Linked to original sources
PubMed1979

The pharmacology of 20681-S and 20682-S, 6-oxo-N-cyclopropylmethylmorphinans, as narcotic antagonist analgesics.

It has been demonstrated that L-3hydroxy-6-oxo-N-cyclopropylmethylmorphinan methansulfonate (20681-S) and L-3,14-dihydroxy-6-oxo-N-cyclopropylmethylmorphinan methansulfonate (20682-S), have antinociceptive and narcotic antagonistic properties. In the rodent antinociceptive test, the action of 20681-S was more potent and of longer duration than that of morphine and of cyclazocine after subcutaneous or oral administration. The antinociceptive effect of 20682-S ranked between that of morphine and that of pentazocine in the mouse acetic acid-writhing test. Both compounds possessed potent narcotic antagonistic activities, 20682-S being more active than naloxone and oxilorphan and 20681-S being equipotent with cyclazocine. The latent side effects (respiratory depression and fall in blood pressure) and the acute toxicity of 20681-S and 20682-S, were less than those of reference narcotic antagonists or of narcotic antagonist analgesics.

Analgesics↗
PubMed1978

A-V block and A-V dissociation in electrocardiographic surveys of middle school students.

(1) ECG surveys were performed on 12,523 middle school students. The incidence of A-V block was 0.04% (0.37% in males and 0.43% in females). The incidence of A-V dissociation was 0.11% (0.09% in males and0.13% in females). (2) There was no case of Mobitz type II or complete A-V block in this survey. (3) Sixty-four school students were picked at random from the students with A-V block who had been diagnosed by ECG surveys during the last there years and were given the Master's two-step test. The following four types of response were recognized; Type 1, Type 2, Type 3A, B, C, and Type 4. (4) Elevation of ASLO and antistreptkinase (ASK) were found in 6.4% and 13.5%, respectively. The serum cold agglutinin titer was elevated in four of the 12 students tested. (5) Most students with A-V block or A-V dissociation had no past history of severe disease or no major complaints.

Adolescent↗
PubMed1978

Determination of zirconium in natural water by spectrophotometry following the concentration step with yield tracer.

Zirconium in natural water samples was determined spectrophotometrically after concentration using95Zr as a yield tracer. Acidified sample (1l) with a known amount of 95Zr was evaporated to dryness, treated with hydrofluoric and nitric acids, and then with nitric and perchloric acids, and evaporated nearly to dryness. The residue was taken up with 2 M perchloric acid and zirconium in the solution was extracted with 0.1 M thenoyltrifluoroacetone (TTA) in benzene. The TTA complex solution was converted to hydrochloric acid solution. After the recovery yield was estimated by measuring the radioactivity of 95Zr in the final solution, zirconium was then determined by spectrophotometry with Arsenazo III. Zirconium contents in lake and hot and cold spring samples from Nikko and Shiobara districts were found to be 0.29-2.8 microgram/l by this method.

Fresh Water↗