Search PubMed⌕ Search

Biomedical subjects

K Hirose

Publications and source records attributed to K Hirose.

At least 253 records · Page 14Linked to original sources
PubMed1995

Cardiac sequelae of Kawasaki disease in Japan over 10 years.

To observe the secular trend of a proportion of Kawasaki disease patients with cardiac sequelae in Japan, we analyzed patients with Kawasaki disease reported to nationwide surveys of the disease during 10.5 years from July 1982 to December 1992. Of 69,382 patients reported to the surveys, 10,596 (15.3%) were reported to have cardiac sequelae such as dilatation or stenosis of coronary arteries, myocardial infarction or valvar lesions, 1 month or more after onset. The percentage of cardiac sequelae was particularly high in males, infants younger than 1 year and children older than 5 years of age. The overall prevalence declined steadily over the observed period. However, the percentage for children older than 5 years of age did not decrease, whether treated with intravenous gamma globulin or untreated. As a consequence of the increased number of patients treated with intravenous gamma globulin, the proportion of Kawasaki disease patients with cardiac sequelae decreased annually. However, the proportion of children older than 5 years of age did not decrease.

Child↗
PubMed1995

Focal conduction block in compression neuropathy of the proximal sciatic nerve.

Direct percutaneous stimulation of the proximal sciatic nerve with a high voltage electrical stimulator was given to a patient with acute sciatic compression neuropathy. Results clearly showed a focal conduction block at the sciatic notch, which could not be precisely localised and quantified by conventional electrodiagnostic methods.

Action Potentials↗
PubMed1995

Inhibitory effect of epinastine on superoxide generation by rat neutrophils.

We studied the effects of antiallergic drugs, epinastine, ketotifen, oxatomide, mequitazine and cromolyn sodium on superoxide anion (O2-) generation from rat neutrophils. Epinastine, ketotifen, oxatomide and mequitazine dose-dependently prevented the N-formyl-Met-Leu-Phe- and phorbol 12-myristate 13-acetate-induced O2- generation, but cromolyn sodium did not prevent it. When membrane and cytosol fractions were incubated with each drug, epinastine, ketotifen and mequitazine prevented O2- generation. On the other hand, when only the membrane fraction was incubated with each drug, ketotifen and mequitazine prevented O2- generation, but epinastine did not. Epinastine may inhibit the NADPH oxidase system through the obstruction of NADPH oxidase-associated cytosol components.

Animals↗
PubMed1995

[A case report of an operation for graft stenosis with complete obstruction of the coronary artery].

A case report of an operation after CABG and AVR was presented. The patient was a 52-year-old female. She underwent CABG with saphenous veins at 43 years old and AVR at 45 years old. She was admitted to our hospital due to acute myocardial infarction. Coronary angiography revealed that all the native coronary arteries were occluded at the proximal side, two grafts to RCA and CX were occluded, and LAD graft had a 99% stenosis. She became critically ill due to low cardiac output and acute renal failure. Endoartrectomy of the LAD graft was performed under CPB. Early postoperative course was uneventful. Severe ST depression in the pre-operative ECG normalized in the postoperative ECG. But she had a chest pain again in the 4th postoperative week. She became critically ill and died on the 43rd postoperative day. It was thought that redo CABG should have been performed after her condition improved.

Aortic Valve↗
PubMed1995

[A case of myokymia with abnormal F responses].

We reported a case of myokymia with abnormal F response. A 60-year-old male with chronic alcoholism was admitted to our hospital with complaint of muscle cramp in both legs just after drinking. Neurological examination revealed muscle pain and weakness of the legs, absence of bilateral Achilles tendon reflexes and prominent myokymia in his right quadriceps femoris and left calf muscles. The electrophysiological examination showed reduced conduction velocity, high amplitude, increased number of phases and long duration of F responses suggesting increased excitability of motoneuron pool. The epidural nerve block brought about a disappearance of the myokymia and an improvement of the abnormal features of F response. The myokymia gradually tended to be milder in the clinical course. The relationship between the myokymia and the abnormal F responses indicated that the increased excitability of spinal motoneurons might play an important role on the generation of myokymia of this patient.

Electromyography↗
PubMed1995

[A case of duodenal duplication and a review of reported cases].

We report a case of duodenal duplication and review of literatures on 43 cases reported in Japan including ours. A 34-year-old female who was admitted with chief complaints of epigastric pain and hematoemesis. An endoscopic examination and a hypotonic duodenography revealed a protruding tumor with bleeding ulcer. Wedge resection of the duodenum, including the lesion, was performed. A diagnosis of duodenal duplication was made by histopathological examination.

Adult↗
PubMed1995

[AIDS/HIV related knowledge, attitude and behavior of acupuncture therapists in Aichi Prefecture].

To promote AIDS prevention measures in Japan, the actual state of knowledge, attitudes and behaviors (KAB) of workers at risk for HIV infection requires clarification. In the present study, acupuncture therapists in Aichi Prefecture were evaluated for level of their KAB. By using a self-administered questionnaire, the KAB condition of 500 acupuncture therapists was surveyed from September-November in 1993. Responses from 494 (98.8%) were available for analysis. Results showed that knowledge level on general issues regarding HIV epidemics was good. The main sources for information on AIDS/HIV were TV, general lectures, public reports and magazines. More than 80% of acupuncture therapists sterilize their needles by autoclave or boiling and 60% of them use disposable needles. Furthermore, 97% of the therapists reported utilizing one or the other of these methods. More than a half of them have participated in AIDS education programs. While about 30% of them responded that they are able to accept HIV carriers as clients, 20% of them expressed negative responses. There appears to be a discrepancy between their level of knowledge of HIV transmission routes and their practical attitude towards clients with AIDS and/or HIV carriers. A more appropriate education program based on behavioral science is desirable to lessen discrepancy distance between general knowledge and preferable behavior regarding AIDS/HIV.

Acquired Immunodeficiency Syndrome↗
PubMed1995

[Multiorgan abnormalities in myotonic dystrophy--correlation among endocrine disorders, central nervous system involvements and gene analysis].

Myotonic dystrophy (DM) is a disease involving multiple organs. To elucidate the extent of severity of the affected organs in a given individual, we performed an investigation of the Ellsworth-Howard test (EH test), intelligence quotient (IQ), apnea index (AI), and expanded DNA fragment (EF) size in 10 patients with DM. The EF size analyzed by standard Southern blot procedures using EcoRI digested genomic DNA extracted from the peripheral white blood cells and probed with cDNA25. In the EH test, these patients were divided into two groups according to the results of their phosphaturic responses (delta P). Of these, 5 patients (Group I) showed a positive delta P, while remaining 5 patients (Group II) showed a negative one. In both Groups I and II, their urinary cyclic AMP responses were positive. Group II showed a significantly low value in IQ (p < 0.02) and a significantly high value in AI (p < 0.02) as compared with Group I. EF size in Group II was found significantly larger than in Group I (p < 0.01). A positive correlation between delta P and IQ (p < 0.1), a significant negative one between delta P and AI (p < 0.01), and a negative correlation between EF size and delta P (p < 0.2) were observed. IQ was negatively (p < 0.05), and AI was positively (p < 0.05) correlated with EF size, which were statistically significant. Our results suggest that the extent of disease severity of the central nervous system is almost the same as that of endocrine organs, and that EF size is correlated with disease severities in both affected organs.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1995

[Effect of supplementation with eicosapentaenoic acid ethyl ester, MND-21, on generation of leukotrienes by calcium ionophore-activated leukocytes in bronchial asthma].

The effects of dietary supplementation with highly purified eicosapentaenoic acid ethyl ester (EPA-E) (MND-21) on asthma symptoms, fatty acids in serum, and generation of leukotriene (LT) C4, LTC5, LTB4 and LTB5 by leukocytes stimulated with calcium ionophore A23187 were studied in 10 patients with bronchial asthma. The patients received nine capsules of MND-21 (2.7 g EPA-E) each day for 12 weeks. Leukocytes obtained from 39 patients with asthma who did not receive EPA-E were used as the control. Fatty acid composition was evaluated by gas chromatography and LT generation was measured by reverse-phase high performance liquid chromatography. EPA-E increased EPA content more than threefold, without changing the quantities of arachidonic acid in serum lipids. Leukocytes obtained from patients given EPA-E for 4 weeks generated less LTC4 (53.5 +/- 23.3 ng/10(7) cells) and LTB4 (24.9 +/- 12.4 ng/10(7) cells) than did those from control patients (142.4 +/- 91.6 ng/10(7) cells and 58.3 +/- 34.8 ng/10(7) cells, respectively). Although significant levels of LTC5 and LTB5 were present after 4 weeks of EPA-E (6.5 +/- 1.9 ng/10(7) cells and 4.6 +/- 2.7 ng/10(7) cells, respectively), generation of total LTC (LTC4 + LTC5) and total LTB (LTB4 + LTB5) were substantially suppressed. Symptoms had improved after two months of EPA-E, but the effect was temporary. We conclude that in patients with asthma, treatment with EPA-E may attenuate leukocyte function without distinctly changing the severity of asthma.

Aged↗
PubMed1995

[Intracellular signal transduction of endocrine organs and expanded DNA fragment size in myotonic dystrophy].

The Ellsworth-Howard (EH) test was performed in 16 patients with myotonic dystrophy (DM), who were divided into two groups according to serum calcium level; Group I showing normal serum calcium (8 patients) and Group II with hypocalcemia (8 patients). Patients in Group II were recognized as having pseudohypoparathyroidism (PHP) type II and those in Group I as normal. Therefore, it was suggested that an abnormality of A kinase might be present in Group II patients. We additionally performed the thyrotropin releasing hormone (TRH) tolerance test in the same patients and 7 normal controls to examine an abnormality of C kinase. delta TSH (delta TSH: peak minus pre TSH) values in DM patients were significantly lower than those in normal controls. Moreover, delta TSH values in Group II were significantly lower than those in Group I. It was suggested that the abnormality of C kinase might be present in Group II patients. Taken together, our results indicated that some patients with DM might possess abnormalities of signal transduction of both A and C kinases. We compared the degree of endocrine involvement determined by both the EH test and the TRH tolerance test with expanded DNA fragment (EF) size determined by standard Southern blot analysis using an appropriate cDNA probe (cDNA25 probe). There was significant negative correlation between EF size and the results of the EH test and negative correlation between the EF size and the results of the TRH tolerance test. These findings suggested that EF size might be correlated with disease severity in affected endocrine organs.

Adolescent↗
PubMed1995

[Clinical analysis of the complex repetitive discharge following M wave].

In the nerve conduction study (NCS), the complex repetitive discharge (CRD) which follows M wave is occasionally observed. To understand the origin of CRD, we clinically analyzed the cases with CRD. Among the 1,580 cases examined by NCS, 13 (0.82%) cases including 6 of myotonic dystrophies (MyD), 2 of carpal tunnel syndrome and a case of multiple sclerosis, chronic inflammatory demyelinating polyradiculoneuropathy, compression fracture of a lumbar vertebra, myasthenia gravis (MG) or Isaacs' syndrome had CRD. CRD was divided into forms; one consisted of an attenuating train of the complex of muscle potentials (muscular form) and the other one formed a simple repetition of single motor unit action potential (neural form). MyD, MG, and Isaacs' syndrome showed muscular form, and the others neural form. The pathophysiology of CRD was considered from the sites of lesions of nerve terminals, neuromuscular junctions, or muscle fibers and that the neural form might result from the axonal regeneration of peripheral motor nerve fibers.

Action Potentials↗
PubMed1994

Life-style and subsite of gastric cancer--joint effect of smoking and drinking habits.

To clarify the effects of life-style on gastric cancer by subsite focusing on the proximal part (cardia and fundus) and the distal part (pyloric antrum), a case-control study was conducted at the Aichi Cancer Center in Nagoya, Japan from 1988-1991. This study compared 668 histologically confirmed gastric cancer cases [123 cardia, 218 middle (body), 256 antrum, and 71 unclassified] with 668 controls using a common questionnaire about life-styles as related to smoking, drinking, dietary habits and frequency of food intake. Controls were selected from among outpatients of the same hospital. Controls free of cancer and other specific diseases were matched with cases for sex, age (within 2 years), and time of hospital visit (within 2 months). A Western-style breakfast decreased the risk of antrum cancer, while consumption of greasy food increased the risk of cardia cancer. Fresh vegetables decreased the risk of cancer in both cardia and antrum. Habitual smoking is associated with increased risk of gastric cancer and it is more prominent in cardia cancer, especially in those who are drinkers. Results obtained from this study suggest that risk factors and relative risks of gastric cancer varied by subsite to a considerable degree. Furthermore, the joint effect of smoking and drinking may play an important role in the development of gastric cancer, especially of cardia cancer.

Alcohol Drinking↗