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Biomedical subjects

K Hill

Publications and source records attributed to K Hill.

At least 163 records · Page 9Linked to original sources
PubMed1977

[Recurrent periarteritis nodosa with predominantly cerebral signs in children (author's transl)].

Periarteritis nodosa occurs also in children and has the same wide spectrum of signs and symptoms as in adults. In a 4 1/2 year-old girl the disease at first was characterised by cerebral, encephalitis-like symptoms, arterial hypertension, intestinal wall necrosis and, finally, pericardial tamponade as a result of rupture of an arteritic coronary artery aneurysm. An earlier attack had involved liver and skeletal muscle, with necrosis in the liver. Peculiar morphological features within the "classical" course of periarteritis nodosa are endarteritic changes of single retroperitoneal and coronary arteries.

Aneurysm↗
PubMed1977

[Tryptic pancreatitis in small-cell bronchial carcinoma (author's transl)].

In two cases of typical small-cell bronchial carcinoma (one of them peripheral, small and clinically not diagnosed) destructive parenchylmal metastases in the pancreas, carcinomatous lymphoangiosis and infiltration of the larger excretory ducts by tumour cells were demonstrated. In both the clinical course was dominated by tryptic pancreatitis with treatment-refractory hypokalaemia. Since pancreatic metastases occur in about 10% of bronchial carcinomas, tryptic pancreatitis is, however, only rarely observed. It is, therefore, likely that autodigestion occurs only if in addition to parenchymal destruction by the metastases there are other factors. These may be blockage of lymphatic flow by carcinomatous lymphangiosis and duct stenosis by tumour infiltration of the walls. Hypercorticism due to ectopic ACTH production by the small-cell carcinoma may also be factor, but is without proof.

Carcinoma, Small Cell↗
PubMed1977

[Frequency and valuation of epitheloid cell granulomas of the spleen in morbus Hodgkin (author's transl)].

Macroscopic and microscopic examination of 154 spleens from patients with lymphogranulomatosis revealed focal alterations in 71 (46%) specimens, 55 ( equals 36%) of which showed typical Hodgkin granuloma while in 16 cases ( equals 10%) the granulomas present were composed of epitheloid cells only. In casu, both Hodkin and epitheloid cell granulomas were macroscopically visible and occurred in normal-sized as well as in enlarged (is greater than 250 g) spleens. However, unspecific alterations had led to splenomegaly, too. The presence of epitheloid cell granulomas in spleens in M. Hodgkin proves that the granulomas indeed are causal pathogenetically linked with lymphogranulomatosis, but are to separate from it substantially. Epitheloid cell granulomas are interpreted as a reaction of the mononuclear phagocyte system in lymogranulomatosis and not as a manifestation of lymphogranulomatosis itself. This should be considered in clinical staging.

Adult↗
PubMed1977

[Pathologc findings in megakaryocytic myelosis (author's transl)].

From 1969--1975 patients with predominantly megakaryocytic myelosis were observed. Diagnosis was made up after histologic examination of iliac crest bone biopsy specimens embedded in methacrylate. From 6 patients rebiopsies and from further eleven ones the removed spleens were available. Autopsy was performed in 12 cases. In our material predominantly megakaryocytic myelosis was especially observed in male patients of advanced ages. The course of the disease was rarely acute, most often chronic and associated with the development of an extreme splenomegaly. Transition into osteomyelofibrosis or osteomyelosclerosis was frequent, the latter condition tended to develop a so-called myelosarcoma. The cause of death often was a generalized hemorrhagic diathesis with gastrointestinal hemorrhage or an fatal infection.

Adult↗