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Biomedical subjects

K Heinonen

Publications and source records attributed to K Heinonen.

At least 91 records · Page 5Linked to original sources
PubMed1986

Plasma vitamin C levels are low in premature infants fed human milk.

To evaluate the vitamin C nutritional status of premature infants, plasma vitamin C concentrations were measured in 7 neonates born before 32 wk of gestation and in 13 premature infants born at or after 32 wk of gestation. Samples of umbilical venous plasma from 14 full-term infants were analyzed to provide reference values. Oral feedings with pooled, pasteurized milk from human donors were initiated 1-3 days after birth and intake was gradually increased to 200 ml X kg X day during the second week. After 2 wk, the 13 larger infants received approximately half of their daily milk intake from their own mothers. Results showed that plasma concentrations of vitamin C decline rapidly after birth and approach very low levels in preterm infants fed pasteurized, pooled human milk.

Ascorbic Acid↗
PubMed1986

Transcutaneous PO2 recording using two sensors in a neonate with preductal coarctation of the aorta.

Simultaneous transcutaneous PO2 (PtcO2) recordings, done on a neonate having preductal coarctation of the aorta, showed markedly lower PtcO2 values in the lower abdominal quadrant (representing postductal blood) than in the subclavicular area (representing preductal blood). Two-sensor PtcO2 recordings are valuable in documenting pathologic ductal shunts commonly associated with disturbed transitional circulation or cardiac malformation in newborn infants.

Aortic Coarctation↗
PubMed1986

Protein quantity and quality in term and preterm infants: effects on urine creatinine and expression of amino acid excretion data.

The effect of dietary protein quantity and quality on the excretion of creatinine in preterm and term neonatal infants has been investigated. Whey protein predominant formulas result in increased creatinine excretion as compared with either casein protein predominant formulas or with pooled human milk in preterm infants (p less than 0.001 by ANOVA). The volume of human milk (170 versus 185 versus 200 ml/kg/day) appears to have little effect in these infants. In term infants, few differences among the feeding groups were observed, although creatinine excretion did increase with time. The pattern of creatinine excretion among feeding groups was similar regardless of whether or not the data were expressed in milligrams per deciliter or in milligrams per 24 hours. Small correlations of creatinine excretion with birth weight were observed, but these appeared to vary, depending on the type of feeding. These diet-induced differences in creatinine excretion indicate the need for caution in expressing other urinary metabolites, such as amino acids, relative to creatinine excretion.

Amino Acids↗
PubMed1985

Neonatal septicaemia.

A total of 410 proved cases of neonatal septicaemia from seven Finnish hospitals seen between 1976 and 1980 were reviewed. The annual incidence of neonatal septicaemia was 3 per 1000 births, and overall mortality was 23%. Onset was early in most patients. Symptoms of septicaemia occurred within the first 24 hours of life in 44% and within the first week of life in 90%. In the very early onset disease (within 24 hours) mortality was 30%, compared with 17% in all other cases. Group B streptococcus was the leading cause in very early onset disease (52%) but mortality from infection with this organism was similar to that in other very early onset cases. It is concluded that very early onset neonatal septicaemia, probably of intrauterine origin and caused by group B streptococcus in one half of the cases, constitutes the major form of neonatal septicaemia in Finland and should receive the highest priority in preventive measures.

Enterococcus faecalis↗
PubMed1985

Intrauterine growth retardation (IUGR) in pre-term infants.

A representative sample (N = 120, 96%) of all pre-term (gestational age less than or equal to 36 weeks) infants born alive to mothers resident in the province of Kuopio, Finland, during a two year period, were studied at birth to evaluate the signs of intrauterine growth retardation (IUGR). Norms for somatic growth were based on measurements of birth weight, length and Ponderal Index (100 X birth weight (g) X birth length (cm)-3) of 51 pre-term singletons, born to healthy mothers after uncomplicated pregnancies, in relation to whom there were no discrepancies between menstrual dates and pediatric assessment of gestational age. The lower limits for normal ranges were defined as values two standard deviations below the expected means for the gestational age. Pre-term IUGR was diagnosed if birth weight and/or birth length and/or PI were more than 2 SD below the expected mean for gestational age. Different types of IUGR were found in 49 pre-term infants (41% of the pre-term population). A low PI was the most common descriptor of IUGR, being present in 42 out of 49 infants. A third of infants had more than one indicator of IUGR. In this population, pre-term IUGR was strongly associated with perinatal maternal pathology (especially hypertension, toxemia and prolonged leakage of amniotic fluid). The neonatal morbidity and mortality among pre-term IUGR infants was markedly higher than that among appropriately grown pre-term infants with corresponding gestational age. There were significantly more cases with fatal intraventricular hemorrhage in pre-term IUGR than in pre-term normally-grown infants.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1984

Chromosome abnormalities in 16 Finnish patients with Burkitt's lymphoma or L3 acute lymphocytic leukemia.

Eleven patients with Burkitt's lymphoma (BL), i.e., small noncleaved non-Hodgkin's lymphoma, and 5 patients with Burkitt-type acute lymphocytic leukemia (ALL-L3) were selected for chromosome study. Two of the 16 patients had no B-cell markers, but the erythrocyte marker--glycophorin A--was present on the surface of the leukemic blasts. The critical breakpoint at 8q24 was detected in 14 of the 16 patients, whereas this aberration was not detected in any of the 134 patients belonging to other subgroups of non-Hodgkin's lymphoma or ALL that we studied during the same period. In addition to the t(8;14)(q24;q32), the following translocations with the breakpoint at 8q24 were seen: t(2;8)(p11;q24), t(8;11)(q24;q13) in BL, and t(2;8;14)(p11 or p12;q24;q32) in ALL. Additional aberrations seen more than once were trisomy #7 and abnormalities in chromosomes #1, #11, and #13.

Adolescent↗
PubMed1983

Initial systolic time intervals as predictors of the severity of transient tachypnea in term neonates.

42 term neonates with transient tachypnea (TTN) underwent echocardiography and determination of systolic time intervals before the age of 4 hours. Based on initial measurement of right ventricular systolic time intervals (RVSTIs) the patients were divided in two groups: neonates with RVSTI ratios less than or equal to 0.50 (Group I) (n = 35) and neonates with RVSTI ratios greater than 0.50 (Group II) (n = 7). Group II neonates also had significantly more prolonged left ventricular systolic time intervals (LVSTIs) than Group I neonates. Group II neonates developed markedly more severe form of TTN than Group I neonates. Initially prolonged RVSTI was best predictor of the development of severe TTN (relative risk ratio 17.5, p less than 0.001): clinical characteristics and oxygen requirements at the admission had limited predictive value.

Electrocardiography↗
PubMed1982

Acute erythroleukaemia with L3 morphology and the 14q+ chromosome.

L3 morphology according to the FAB classification and the 14q+ chromosome are usually ascribed to the Burkitt type of leukaemia or lymphoma with a B or pre-B cell phenotype. We report here a case of adult acute leukaemia with Burkitt morphology and the 14q+, which did not express lymphoid markers. Instead, the leukaemia was shown to be an acute erythroleukaemia. The erythrocyte marker glycophorin A was present on the surface of the leukemic blasts as shown by immunofluorescence and immunoprecipitation from membrane lysates of surface labeled cells with antiglycophorin A antiserum. Spectrin and fetal hemoglobin appeared after cultivation of the blasts in the presence of sodium butyrate. The present case shows that a short term cultivation is sometimes useful for further characterization of the commitment of acute leukaemias.

Acute Disease↗