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Biomedical subjects

K Hayes

Publications and source records attributed to K Hayes.

At least 145 records · Page 8Linked to original sources
PubMed1980

Herpes virus in an obstetric hospital. II: Asymptomatic virus excretion in staff members.

Serial studies of specimens of saliva from 384 asymptomatic members of staff of an obstetric hospital resulted in the isolation of herpes simplex virus (HSV) from 9.6%. This exposure rate of patients to HSV infection was contrasted with the very low incidence of HSV infection in neonates in Australia. Factors associated with the incidence of overt HSV infection and intermittent asymptomatic excretion of HSV were noted and assessed in relation to possible sites of virus location.

Adult↗
PubMed1980

Herpes virus in an obstetric hospital: I: Herpetic eruptions.

In a one-year prospective study, 199 of 347 (34%) staff members in direct contact with patients reported 165 non-genital herpes simplex virus (HSV) infections. The mean working time lost due to these infections was 4.7 days (aggregate, 778 days for the year). Serum antibody titre was not significantly associated with the recurrence rate or the duration of infection. A comparison was made of the ethnic, social and environmental histories of staff members prone to HSV infections and of seronegative staff members with no record of cold sores. The absence of effective treatment at present is noted.

Adult↗
PubMed1979

Maternal immunosuppression and cytomegalovirus infection of the fetus.

Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE). Serology showed that maternal CMV infection had been acquired at least four months before pregnancy. Screening for CMV infection in pregnant women receiving immunosuppressive drugs is recommended.

Adult↗
PubMed1978

Homologous and heterologous antibody responses to subunit influenza virus vaccine.

In a group of 32 adult volunteers given subunit influenza virus vaccine containing 250 international units (i.u.) of A/Victoria/3/75, 250 i.u. of A/Scotland/840/74 and 300 i.u. of B/Hong Kong/8/73, there were substantial increases in the geometric mean homologous haemagglutination-inhibiting (HI) antibody titres. There was also substantial boosting of the antibodies to the earlier variants of the Hong Kong (H3N2) series and to a later variant of the Asian (H2N2) series. There was no boosting of antibodies to the A/FM/1/47 strain, a representative member of the H1N1 series, but two individuals showed substantial rises to A/PR/8/34 (HON1). There were increases in the HI titre of antibodies cross reactive with two recent isolations, A/Texas/1/77, and A/Victoria/35/77, but the majority of vaccinees failed to reach antibody titres likely to be protective against such strains.

Antibodies, Heterophile↗
PubMed1978

Cytomegalovirus and herpes simplex virus: wolves in sheep's clothing.

The herpesviruses cytomegalovirus and herpes simplex are common human infections. They are usually subclinical, but can cause significant or even fatal disease. The foetus, the newborn and the immunocompromised are particularly vulnerable to the serious consequences of these opportunistic infections.

Cytomegalovirus Infections↗
PubMed1976

Systemic herpes simplex infection with fulminant hepatitis post-transplantation.

Immunosuppression for renal transplantation is associated with the risk of severe overwhelming infection with ubiquitous but normally relatively harmless micro-organisms. In recent years a number of adult cases of fatal hepatitis due to herpes simplex virus (HSV) infection have been reported. Nearly always immune deficiency was a significant factor. A case of fatal HSV infection with hepatitis following transplantation is reported. The case failed to respond to infusion with the antiviral agent cytosine arabinoside. The presentation, diagnosis and treatment of HSV fulminant hepatitis is discussed.

Adolescent↗
PubMed1971

Congenital perceptive deafness: role of intrauterine rubella.

Rubella antibody was detected in 85 (61%) of 139 children aged from 6 months to 7 years with congenital perceptive deafness. Of the 112 children who were aged under 4 years 61 (54%) had rubella antibody (seropositive) compared with 7.1% in randomly selected children of the same age. A close correlation was found between the presence of antibody in children with perceptive deafness and (1) a maternal history of rash or contact in early pregnancy, and (2) with the presence of other rubella-type defects. Intrauterine rubella was thought to be the cause of the deafness in 82 (59%) of the 139 children, in 60 of whom deafness was the only rubella defect detected. Thus intrauterine rubella should be considered a likely cause of congenital perceptive deafness in a child under 4 years in whom rubella antibody is present.

Antibody Formation↗
PubMedDate not supplied

Generating ideas for research: an Australian research experience.

Recent changes in the educational system and career developments in Australia have provided Australian clinical nurses with an opportunity to conduct research in their practice. In this article, the nursing staff of an Australian gastroenterology unit describe their experience in defining a research project.

Australia↗