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Biomedical subjects

K Harima

Publications and source records attributed to K Harima.

At least 19 recordsLinked to original sources
PubMed1995

[A Japanese family with congenital abnormal plasminogen].

A Japanese family with congenital abnormal plasminogen is reported. The patient was a 44-year-old male with no past history of thrombosis. Since only the plasminogen (PLG) activity was reduced on laboratory tests before surgery for lumbar disc herniation, coagulation and fibrinolysis studies were performed in the patient and his family. The patient underwent resection of the nucleus pulposus and posteriorlateral fixation of the lumbar spine. The PLG activity was 8% in the patient and his sister, 55% in his father, and 53% and 48% in his nephew brothers. The PLG antigen level was normal in all members of his family examined. IEF of PLG antigen showed abnormal patterns in which all bands were shifted slightly to the cathode side in the patient and his sister, but his father and nephew brothers exhibited duplicated bands showing combinations of normal and abnormal patterns. From these results, the proband and his sister were considered to be homozygotes, and his father and nephew brothers to be heterozygotes for congenital abnormal plasminogen. Acute reactant substances (fibrinogen, CRP, CPK, C1IN, alpha 1AT, etc.) and PIC (plasmin, alpha 2-plasmin inhibitor complex) increased after the operation due to the surgical insult, but the surgery did not trigger thrombosis. This patient is considered not to have developed thrombosis although he was a homozygote for congenital abnormal plasminogen, because the anticoagulation process until thrombogenesis was normal.

Adult↗
PubMed1994

[Change in lobar uptake of 99mTc-galactosyl serum albumin after transarterial embolization therapy].

Liver function was studied by hepatic scintigraphy with 99mTc-galactosyl serum albumin (GSA) before and after transarterial embolization (TAE) therapy in 16 patients with hepatocellular carcinoma. The percent uptake of GSA in liver was measured separately in the treated and non-treated areas. GSA uptake increased in both areas. The change was more marked in the non-embolized lobe than the embolized lobe. We conclude that the increase in GSA uptake reflects the regeneration of liver cells after TAE.

Carcinoma, Hepatocellular↗
PubMed1994

[Clinical study of cyclic intra-arterial chemotherapy using mitoxantrone for advanced hepatocellular carcinoma].

Cyclic intra-arterial infusion chemotherapy using Mitoxantrone via reservoir system was prescribed for 8 patients with advanced hepatocellular carcinoma. According to the clinical staging system, two patients were in Stage III and the other six patients in Stage IV-A. Vp-3 portal invasion was observed in six out of the eight patients. Mitoxantrone (5-8 mg/body) was administered intra-arterially via port-a-cath device every 4 weeks. For tumor response, there were two PR cases, four NC cases, and two PD cases. Thus, the response rate was 25%. The mean survival period was 6.5 months, and 1-year survival rate was 13%. In one of two PR cases, the survival time has been more than two years so far. Gastrointestinal toxicities such as nausea and vomiting were not severe. Critical myelosuppression requiring medication was not observed. Although a temporary increase of serum bilirubin was found in two cases, no severe damage to hepatic function was observed. From our preliminary data, this arterial infusion chemotherapy using Mitoxantrone via reservoir system can be safely performed on non-hospitalized patients with advanced hepatocellular carcinoma, and may be a useful treatment modality.

Aged↗
PubMed1992

[Disappearance of lung metastases from hepatocellular carcinoma following bronchial arterial infusion of CDDP and MMC].

A 58-year-old man was admitted to our department because he had been diagnosed as hepatocellular carcinoma, which was located at S6 segment, and posterior segmentectomy was performed. After 6 months, right lung metastases of HCC were found and right bronchial arterial infusion of CDDP and MMC was performed twice. Dramatic effects were obtained such as disappearance of lung metastases. We emphasize the useful effect of CDDP and MMC for metastases of HCC.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1991

[Long-term results of transcatheter arterial embolization therapy in cases of recurrent and advanced pelvic cancer].

From April 1983 through April 1989, transcatheter internal iliac arterial embolization therapy (TAE) using Gelfoam particles was performed in 64 cases of recurrent or advanced pelvic cancer. We report here 19 patients who survived for more than one year. After TAE, the patients were followed on an outpatient basis for an average of two years. The condition of the patients was generally good during this period of follow-up. Complete response (CR) to therapy was obtained in five cases, partial response (PR) in nine, minor response (MR) in one and no change (NC) in four. Among the five cases that showed complete response, one case had local control for over five years, two cases for over three years and two cases for over one year. Though the patients had cancer, there were no other complications during the long-term follow-up.

Adult↗
PubMed1990

[Transcatheter arterial embolization therapy in cases of recurrent and advanced pelvic cancer--estimation by Cox's proportional hazard model].

From April 1983 through September 1988, transcatheter internal iliac arterial embolization therapy (TAE) using Gelfoam particles was performed in 36 patients with recurrent pelvic cancer and 18 patients with advanced pelvic cancer. The tumor showed complete response (CR) to the therapy in seven patients, partial response (PR) in 18, minor response (MR) in five, and no change (NC) in 24 patients, with the response rate (CR + PR) of 46.3%. Univariate analysis, using Kaplan-Meier estimates and log-rank test, revealed that overall survival was related to performance status (p = 0.0001) and tumor reduction by TAE (p = 0.0008). Similarly, a multivariate analysis, using Cox's proportional hazard model, revealed a strong relationship between prognosis and performance status and tumor reduction by TAE. These results show that both good general condition and tumor reduction by TAE are significant characteristics for the prognosis of recurrent and advanced pelvic cancer treated by TAE.

Adult↗
PubMed1990

Advanced vulvar carcinoma treated with internal iliac arterial embolization therapy after radiotherapy.

Two patients with vulvar carcinoma are reported who were treated with internal iliac transcatheter arterial embolization and radiotherapy. Patient 1 had T3N3M0 vulvar carcinoma. The lesion remaining after radiotherapy was treated by bilateral internal iliac arterial embolization. Vulvectomy was then performed, and the resected specimen showed no residual malignant cells. This patient is alive without recurrence 4 years 7 months after operation. Patient 2 (T3N0M0 vulvar carcinoma) underwent radiotherapy, and the remaining malignant tumor disappeared after bilateral internal iliac artery embolization. This patient has remained disease free without vulvectomy for 3 years after treatment.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1990

[A clinical evaluation of distant metastases from a hepatocellular carcinoma with reference to location, frequency, symptoms, treatment & prognosis].

A clinical analysis of patients with hepatocellular carcinoma (HCC) associated with a distant metastases has been undertaken by the authors. Studied were eight patients (Group A) whose distant metastases were detected at the time of their initial examination, and 24 patients (Group B) whose distant metastases had been diagnosed during the course of treatment of their primary lesions. Complications arising from liver cirrhosis in Group A was less than in Group B. The location of the metastases were the bone in 16, the lung and the adrenal gland in four, the brain and the skin in two and the kidney in one. The mean survival times were 4.6 months (Group A), and 6.3 months (Group B). The cause of death was chiefly a progression of the primary lesion, except for one brain metastases. This analysis had shown that treatment of a bone metastasis is necessary for the relief of pain, and that care should be taken for the prevention of a fracture or paralysis, and that control of the primary lesion is necessary for improving the chances of survival.

Adrenal Gland Neoplasms↗
PubMed1989

Transcatheter arterial embolization therapy in cases of recurrent and advanced gynecologic cancer.

Transcatheter internal iliac arterial embolization therapy (TAE) using Gelfoam particles was performed in 24 patients with recurrent gynecologic cancer and ten patients with advanced gynecologic cancer who had previously undergone radiotherapy. The tumor showed complete response (CR) to the therapy in six patients, partial response (PR) in 12, minor response (MR) in three, and no changes (NC) in 13 patients, with the response rate (CR + PR) of 52.9% (18 of 34). No serious or prolonged side effects were encountered except for vesicovaginal fistula in three patients and renal failure in one. The median duration of survival was 299 days, and the 1-year cumulative survival rate was 32.5%. The factors that were associated with favorable outcome after TAE were good general condition, no distant metastases, tumors less than 5 cm in diameter, and responses to the therapy of PR or better. Thus, TAE appears useful for the treatment of recurrent and advanced gynecologic malignancies.

Adult↗
PubMed1989

[Esophago-bronchial fistulas in adult].

Esophago-bronchial fistulas in adult are rare and for the most part are due to a malignant tumor. The authors present two cases of benign Esophago-bronchial fistula which were discovered accidentally by esophagography. One case was considered to be congenital. Esophagography is the most useful for diagnosis of this disease.

Bronchial Fistula↗
PubMed1989

[The usefulness of 99mTc-PMT cholescintigraphy in the diagnosis of bile leakage or biloma].

5 cases (6 lesions) of bile leakage or bilomas were experienced. All cases showed high accumulative areas in the lesions of bile leakage using 99mTc-PMT cholescintigraphy, while US and CT studies showed no specific findings of fluid-filled areas. Cholescintigraphy demonstrated communications between the injured biliary systems and other spaces very clearly. Even if the needle aspiration failed to get a characteristic bile, which were sometimes seen in bilomas complicated with infection or bleeding, cholescintigraphy was useful for the accurate diagnosis. It is also useful for monitoring the bile drainage.

Aged↗
PubMed1989

[MRI of the paranasal sinus mucopyocele].

Seven cases of the paranasal sinus mucopyocele were examined by MRI. All of the mucopyocele in our series were clearly demonstrated on MRI using long SE pulse sequence as high signal intensity. However, the degree of signal intensity was varied based on the contents of the mucopyocele. We can detect the mucopyocele as a three dimensional image by MRI, however, CT was necessary for evaluating the bone destruction caused by mucopyocele.

Adult↗
PubMed1989

[Multi-modal treatment of patients with multiple liver metastases caused by sigmoid cancer].

A case of sigmoid cancer with multiple liver metastases (S2PON3 + H3) who was treated by multi-modal treatment was reported. The multi-modal treatment is including intra-arterial administration of anti-cancer drugs as a pre-surgery treatment, intra-arterial infusion chemotherapy lasting for three to five weeks (three times), hyperthermia treatment combined with intra-arterial administration of anti-cancer drugs and intra-arterial expandable metalic stent. The patients lived for 2 years and 4 months in good condition.

Aged↗
PubMed1988

[Radiosensitizing effects of perfluorochemicals].

Malignant neoplasms are often refractory to radiotherapy because they contain areas of hypoxic cells that tolerate irradiation, reducing the effect of the treatment. If these areas of hypoxic cells can be oxygenated, the effect of radiotherapy is expected to be enhanced. Hyperbaric oxygen therapy was devised in the 1950s, and the radiosensitizing agent Misonidazole was developed in 1970. However, neither produced satisfactory clinical effects in radiotherapy of tumors. In this study, hypoxic cells in a solid tumor were efficiently oxygenated by the use of perfluorochemicals (PFC) developed as artificial blood with carbogen gas (CG), and the anti-tumor effect of irradiation was enhanced. In C3H mice bearing RIF-1 tumor, the mean oxygen pressure increased to 79.8 mmHg in those treated with PFC and CG as compared with 12.9 mmHg in the controls, and the does modification factor in irradiation of these mice was TCD50 1.47. PFC is currently under clinical trials, and we also noted effective oxygenation of tumors. These findings indicate the usefulness of PFC as a radiosensitizing agent.

Angiotensin II↗