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Biomedical subjects

K Haram

Publications and source records attributed to K Haram.

67 records · Page 4Linked to original sources
PubMed1976

Transplacental passage of diazepam following intravenous injection immediately prior to operative vaginal delivery.

The early phase of diaplacental transfer of diazepam was studied in 39 women given the drug as a basic anaesthetic for operative vaginal delivery indicated by prolonged second stage of labour (9 cases), breech delivery (19 cases) and intrauterine hypoxia (11 cases). A total dose of 30 mg diazepam (Valium Roche) was injected intravenously over a period of 15 sec umbilical cord blood was collected immediately after delivery. Diazepam was extracted with diethyl ether and determined by gas chromatography. The concentration of diazepam in cord blood increased from greater than 5-250 ng/ml at 57-60 seconds to 48-1861 ng/ml at 90-100 seconds after completion of the intravenous injection. Thereafter a plateau seemed to be reached but the interindividual variation was still great with values ranging from 45-3034 ng/ml up to 360 seconds. Judged by Apgar score and the clinical course the neonates seemed to be unaffected by the medication administered to the mother.

Anesthesia, Obstetrical↗
PubMed1976

Serum alkaline phosphatase in pregnancy. II. Serial HSAP65degreesC estimations in pregnancy complicated with hypertension and pre-eclampsia.

This is a study of heat-stable alkaline phosphatase (HSAP65degreesC) concentrations in the serum of pregnant women with hypertension (42 cases), mild preeclampsia (40 cases) and severe pre-eclampsia (22 cases). The results are seen in relationship to the occurrence of intrauterine fetal death, growth retardation, intrauterine and neonatal asphyxia as well as the respiratory distress syndrome (RDS) in the newborn. The importance of a precise clinical classification of the patients is stressed. Pathological HSAP values are those which lie either over or under the normal range for HSAP activity. In addition "zig-zag" curves with values within the normal range are characterized as abnormal. Thus, serial estimations give the most reliable results. Serial estimations of HSAP are especially valuable in severe pre-eclampsia. Abnormal HSAP values in the 28th-38th week of pregnancy are a serious prognostic sign. False abnormal HSAP results were found in all 3 patient groups. One possible false normal HSAP curve also occurred.

Alkaline Phosphatase↗
PubMed1975

Endolymphatic stromal myosis: report of a case treated surgically and with hormones.

Stromal endolymphatic myosis is regarded as a mixed homologous tumour with a prominent proliferation of the stroma and a varying degree of proliferation of glandlike structures and vessels. A case is presented in which the patient was treated periodically with progestine. This therapy seems to have been of benefit in controlling the frequency of recurrence.

Adult↗
PubMed1975

Serum alkaline phosphatase in pregnancy. I. A comparative study of total, L-phenylanine-sensitive and heat-stable alkaline phosphatase at 56 degrees C and 65 degrees C in normal pregnancy.

312 paired, serial estimations of total, L-phenylalanine-sensitive and heat-stable alkaline phosphatase (at two temperatures, 56 degrees C and 65 degrees C) were performed on sera from 31 pregnant healthy women from 18 weeks to term. Heat-stable alkaline phosphatase, determined at 65 degrees C, enriched the serum in a smooth exponential course throughout the second and third trimester, whereas the other enzymic activities investigated showed more irregular increments. There was a slight, but significant correlation between total alkaline phosphatase activity of the placenta and serum heat-stable alkaline phosphatase at term, whereas there was no correlation between the weight of the child at birth and heat-stable alkaline phosphatase in the serum of the mother. It is concluded that to test the feto-maternal unit, determination of serum alkaline phosphatase should be performed at 65 degrees C with due regard to appropriate sampling and experimental design.

Alkaline Phosphatase↗
PubMedDate not supplied

Choriocarcinoma associated with thyrotoxicosis: a case report.

A woman with disseminated choriocarcinoma and with clinical and biochemical evidence of thyrotoxicosis is described. Only a few cases have been previously reported, and works are referred to showing that high levels of human chorionic gonadotropin (HCG) probably are responsible for the thyroid-stimulating activity in patients with trophoblastic disease and clinical signs of thyrotoxicosis.

Adult↗
PubMedDate not supplied

Time-course of transplacental passage of diazepam: Influence of injection-delivery interval on neonatal drug concentrations.

Neonatal drug concentrations and neonate/mother concentration ratios are reported in 73 cases of elective Caesarean section and forceps deliveries where diazepam was used as an intravenous sleep-inducing agent. The various parameters were plotted against the injection-delivery interval and the correlation was tested using a non-parametric ranking method. The concentration of diazepam in mixed arteriovenous umbilical cord blood was negatively correlated with the injection-delivery interval in the range of 55 to 810 seconds. Statistically significant positive correlation (p less than 0.001) were found between the injection-delivery interval and the neonatal concentrations at 2 and 24 hours. The corresponding neonate/mother concentration ratios varied considerably, and were not so strongly correlated to the duration of antenatal drug transfer. The results suggest that with a slowly eliminated agent like diazepam, the drug concentration in capillary blood obtained from the newborn a few hours after delivery gives a reasonably good indication of the fetal drug exposure. The transplacental passage of diazepam is rapid, with distribution equilibrium between mother and fetus approached within 5 to 10 minutes after intravenous injection of the drug.

Adolescent↗