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Biomedical subjects

K Harada

Publications and source records attributed to K Harada.

At least 1,207 records · Page 67Linked to original sources
PubMed1981

[Rathke's cleft cyst -a case report (author's transl)].

A 17-year-old male was admitted to the Department of Neurosurgery, Hiroshima University Hospital because of an enlarged sella turcica which had been pointed by the skull x-ray examination performed for the facial contusion of the traffic accident. CT scan revealed an oval shaped area of hyperdensity in the center of the sella without any extrasellar extensions. After contrast administration this area showed almost no increased density. The patient had no neurological abnormalities except for hyposmia and left blindness due to the traffic accident. Endocrinological studies were normal. From these findings non-functioning intrapituitary adenoma was suspected and exploration of the sella through the transsphenoidal route was performed. When the dura mater was opened, about 1.5 microliter of white mucous colloid material was exposed. This material fully occupied the pituitary fossa and the pituitary gland was compressed upward. Histologically the cyst wall was composed of pseudostriated columnar ciliated epithelium and partially squamous metaplasia was seen. These epithelium and colloid material structure were stained by PAS-Alcian blue. The tubular gland-like structure was visible in the posterior lobe adjacent to the cyst wall. The size of Rathke's cleft cyst, its pathogenesis, its findings by CT scan and surgical aspect were discussed.

Adolescent↗
PubMed1981

A modified dose monitoring system in remote afterloading therapy of carcinoma of the uterine cervix using semi-conductor dosimeter.

A dose monitoring system in high dose rate intracavitary remote afterloading therapy of carcinoma of the uterine cervix using semi-conductor dosimeter was developed in July 1979 at our department. During early experience with the above system, extremely high values of mgh as well as high doses to rectum and bladder were encountered in the cases with poor local anatomy or unsuitable application. Solving this problem, such limitations as to the mgh as well as point-A dose were added to the computerized rapid processing system for the pretreatment dose calculation and correction of the treatment parameters to adjust the point-A dose to within +/- 5% of the planned dose. In the majority of the cases treated with Ralstron, this modified dose monitoring system brought considerable success in the optimization of point-A, mgh, rectal and bladder doses, in a simple manner.

Brachytherapy↗
PubMed1981

[Two clinical cases diagnosed provisionally as Binswanger type of vascular dementia--on possibility to its clinical recognition from neuropsychiatric findings and computed tomography (author's transl)].

The diagnosis of subcortical arteriosclerotic encephalopathy of Binswanger should be confirmed neuropathologically by postmortem examination. But we expect that it may be possible to diagnose provisionally as Binswanger's disease on the basis of clinical course and findings including computed tomography. Two cases, 57 years old postman (case 1) and 60 years old housewife (case 2) were reported. They had hypertension for over 20 years in their past history and showed a progressive dementia since before one year and 9 years. Transient syncopal attack and epileptiform seizure revealed occasionally. Psychiatrically either of them were apathetic, aspontaneous and autistic. One of them (case 2) showed a striking paranoid-hallucinatory state. Spastic gait disturbance and dysarthria are found neurologically, and moreover in case 1 revealed the incontinence of urine and feces. Arteriosclerotic changes were seen in the fundi. The EEG showed a slow alpha rhythm with scattered theta- and delta-waves. Laboratory data of blood, urine and CSF were normal. On the basis of these clinical course and findings the diagnosis of Binswanger's type of cerebral arteriosclerosis were suspected. The CT-scan of 2 cases proved a symmetrical enlargement of the lateral ventricles and marginated areas of definite abnormal low density in the white matter of the occipital (case 1) and frontal (case 1 and 2) lobes. Conclusively we may provisionally diagnosed our two cases as Binswanger's disease, also supported by the findings of CT.

Dementia↗
PubMed1981

Effect of intracerebral administration of Corynebacterium parvum on the growth of brain tumors in mice.

The effect of intracerebral administration of Corynebacterium parvum (C. parvum) on the growth of syngeneic brain tumors in C57BL/6 mice and the mechanism of its action were investigated. Mice were inoculated with 10(4) malignant glioma cells intracerebrally, and treated with various doses of C parvum on day 6 after tumor inoculation. The growth of tumors was significantly inhibited in proportion ot the dose of C. parvum. The cytotoxic activity of effector cells was enhanced when C. parvum was administered at the site of tumor inoculation. Significant cytotoxic activity was observed in the adherent cell fraction of brain mononuclear cells, while less cytotoxic activity was observed in the nonadherent cell fraction. These results indicate that activated intracranial macrophages may participate in the tumoricidal effect of intracerebral C. parvum administration.

Animals↗
PubMed1981

[Survey on intestinal Behçet's disease in Hokkaido (author's transl)].

The occurrence of intestinal Behçet's disease is not common so that misdiagnosis with inappropriate treatment often results in death. Due to this circumstance intestinal Behçet's disease is noted as a very serious complication of Behçet's disease. The identity of intestinal Behçet's disease and its patient manifestation remain obceure. As members of the national project team for intestinal Behçet's disease, we surveyed the state of intestinal Behçet's disease in Hokkaido. The results are summarized as follows: 1) The occurrence in Hokkaido of intestinal Behçet's disease is higher than the national average in concordance with a high rate of Behçet's disease itself. 2) Intestinal Behçet's disease, incomplete type, was observed to be more frequent in the female which differs from the other complications of Behçet's disease. 3) Ulcers which develop in the ileus are apt to perforate (85.7%) giving rise to frequent emergency operations. On the other hand, ulcers in the ascending colon are not as liable to the perforate (25.0%). 4) Ulcers which develop in the ileum are often round with the part under the surface being quite deep and large. Ulcers in the ascending colon are usually of various shapes and are not very deep. 5) Through a retrospective review of the cases of Behçet's disease, the probability of an ulcer occurring or not is difficult to predict at this time.

Adult↗
PubMed1981

[Histopathologic and cytologic studies on uterine sarcomas (author's transl)].

Non-epithelial tumors originating in the uterus are a relatively rare affliction, accounting for less than 3% of all malignant uterine neoplasms. For this reason, there are at present few cytological reports on these sarcoma, so that histological determination on the basis of cytological diagnosis becomes quite difficult. On this occasion, We are privileged to report on cytological examinations we have made over the past decade on six cases involving uterine sarcomas in the course of our practise at the Iwate Medical University School of Medicine. The histological diagnosis of these tumor were Leiomyosarcoma (1 case) Mixed mesodermal tumor (1 case). Rhabdomyosarcoma (1 case). Carcinosarcoma (2 cases), and Mixed cell sarcoma (1 case). The cytologic findings of these tumor cells in vaginal smear and aspiration smear of uterine cavity are as follows: 1) In all cases, We observed the appearance of tumor cells of undifferentiated non-epithelial origin, showing an almost identical configuration. 2) Also, in these various sarcomas, We confirmed distinctive tumor cells from which histologic type could be inferred. This suggested the possibility of histologic type diagnosis on the basis of cytological diagnosis.

Adolescent↗