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Biomedical subjects

K Harada

Publications and source records attributed to K Harada.

At least 1,045 records · Page 58Linked to original sources
PubMed1986

[Intracranial hemorrhage associated with pregnancy--4 case reports and a review of the literature].

Four cases of intracranial hemorrhage associated with pregnancy are reported. They were a ruptured anterior communicating aneurysm, a ruptured AVM of cerebellar hemisphere, a lt-thalamic and putaminal hemorrhage and brain stem hemorrhage. As the mode of hemorrhage, one case was a subarachnoid hemorrhage, one case was a subarachnoid hemorrhage combined with a cerebellar hemorrhage and other two cases were intraparenchymal hemorrhage. The mean age of these 4 cases was 29.5 years of age from 25 to 35. One case was occurred the intracranial hemorrhage during the first trimester but other 3 cases was occurred during the third trimester. It was, thus, considered the intracranial hemorrhage associated with pregnancy was more frequently occurred during the third trimester. Primigravida and multigravida were equally occurred on each two cases. It was not related to parity. Consciousness levels were drowsiness; one case, semicoma; two cases and deep coma; one case. A case of ruptured anterior communicating aneurysm underwent neck clipping of aneurysm through the rt-fronto-temporal craniotomy on the first day of the attack. This case fully recovered, but the other three cases of severely impaired consciousness level were dead. Maternal prognosis was related to consciousness level. We mentioned the preferred neurosurgical and obstetrical management to the intracranial hemorrhage associated with pregnancy.

Adult↗
PubMed1986

[Cerebellar astrocytoma presenting with cerebellar hemorrhage: a case report].

UNLABELLED: A rare case of cerebellar astrocytoma presenting with cerebellar hemorrhage is reported. On reviewing the literature, we could collect only four other cases of spontaneous hemorrhage in cerebellar astrocytomas. CASE: On April 5, 1984, a 15-year-old boy noted a sudden onset of headache, vomiting and vertigo and became lethargic and confused. He was admitted on the next day. General examinations, including bloodpressure, temperature and laboratory tests, were found to be normal upon admission. The patient was in somnolence with nystagmus and left dysdiadochokinesis. The result of the left nose to finger test was poor. Computerized tomography revealed a mass leison with calcification and hemorrhage in the paramedian part of the cerebellum. Fourty days after admission, suboccipital osteoplastic craniotomy was performed. A hematoma was found in the paramedian part of the cerebellum. A tumor mass with rich vascularity was completely removed together with the hematoma. Histologically this tissue was a low grade fibrillary astrocytoma accompanying calcification and hemosiderin suggesting tumoral hemorrhage. He regained his neurological functions satisfactorily and was discharged 2 months later.

Adolescent↗
PubMed1986

[The changes in nuclear DNA amounts in the development and progression of uterine cervical cancer determined by cytofluorometry].

After microsopically-directed sampling of the tissues from various histological sections taken from 16 cases of cervical dysplasia, 6 cases of carcinoma in situ, 11 cases of stage Ib invasive cervical cancer of keratinizing type, 28 cases of large cell non-keratinizing type and 14 cases of small cell type, nuclear DNA levels of the cells dispersed from the tissues were measured by cytofluorometry after Feulgen stain. The DNA levels of cells obtained from normal cervical squamous epithelium and squamous metaplastic epithelium were in 2C(diploid)-4C(tetraploid) regions and those from mild and severe dysplasia were in 2C approximately 4C or high 4C and in low 2C or 2C approximately high 4C or 8C(octaploid) regions respectively with the mode of 2C. In five of 6 cases (83.3%) of carcinoma in situ, the amount of DNA in the neoplastic cells ranged up to the hyperoctaploid region with the mode of 2C or 4C. There were hyperoctaploid cells in 90.9% of cases of the keratinizing type, 96.4% of cases of the large cell non-keratinizing type and 100% of cases of the small cell type. The incidence of hyperoctaploid cells in samples from superficial invasion (stromal invasion less than 3mm) was not different from that of deep invasion (stromal invasion of more than 5mm) in each histological type. When the modal values for nuclear DNA in the superficially invasive lesions were compared with those of the deeply invasive lesions, aneuploidy was more frequently observed in the lesions of deep stromal invasion, irrespective of the histological type. The dominant changes in the mode according to the depth of stromal invasion were 2C to aneuploid in keratinizing type and 4C to aneuploid in cases of large cell non-keratinizing type and small cell type. The results suggest that the hyperoctaploid and aneuploid cells are useful markers for quantitative discrimination among dysplasia, carcinoma in situ and invasive squamous cell carcinoma and that aneuploid stem cells may be generated from 2C and 4C stem cell lines in the progression of stromal invasion.

Carcinoma in Situ↗
PubMed1986

[Two cases of intracerebral hemorrhage in full-term neonatal infants].

Intracranial hemorrhage in neonatal infants is mostly noted in the subependymal or subdural space. The former is characteristically noted in premature infants and is attributed to hemorrhage from the subependymal germinal matrix layer. The latter is prevalently noted in full-term neonatal infants and is thought to be associated with injury in the vicinity of the falx cerebri or tentorium cerebelli. We report two cases of intracerebral hemorrhage, which is relatively rare in full-term neonatal infants. In both of them hematoma was located in the left frontal area adjacent to the coronal suture. Angiogram did not reveal any causative abnormality. From CT scan and intraoperative findings it is speculated that the hemorrhage was caused by moulding at the coronal suture. In other words, moulding made the frontal bone slipped in beneath the parietal bone at the coronal suture causing pressure over the brain. The hemorrhage is thought to be caused by contusion of fragile vasculature of neonatal infants.

Cerebral Angiography↗
PubMed1986

[Ganglioglioma in a child--report of a case].

A seven-year-old boy who was admitted for surgical treatment for intractable epilepsy was found to have a ganglioglioma in his left parietal lobe. Since four years old, he had been suffering from the seizure and treated with various anticonvulsants without satisfactory effects. As its frequency increased, the dose had to be increased. Thus, it was sought for the possible surgical approach. On the CT scans, an egg size low density zone without contrast enhancement was observed in the subcortical region of his parietal lobe. There was marked thinning on inner table of the skull immediately above the zone. He was operated under fronto-temporo-parietal craniotomy. When the dura matter was opened, pale cerebral cortex protruded. Complete removal of the tumor was not possible, since there was not clear boundary between the mass and normal tissue. Based on histological study, it was diagnosed as ganglioglioma, because its main body contained increased number of glia which had deeply stained ununiform size nuclei. After the operation, he showed neither motor paralysis nor sensory disturbance and was able to sustain his activity with less amount of anticonvulsant.

Brain Neoplasms↗
PubMed1985

Six cases of central serous choroidopathy induced by systemic corticosteroid therapy.

We report 6 cases of central serous choroidopathy (including pigment epithelial detachment in one case) which appeared in the course of systemic corticosteroid administration conducted to cure concurrent general diseases, and in one patient with a steroid-releasing pituitary adenoma. The majority of cases arose within about one month following the administration of more than 200 mg of prednisolon. It is postulated that corticosteroids operate as a kind of stress intervening in the hypophysis-adrenal system, leading eventually to the development of central serous choroidopathy.

Adrenal Cortex Hormones↗