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Biomedical subjects

K Hara

Publications and source records attributed to K Hara.

At least 1,135 records · Page 63Linked to original sources
PubMed1982

Rhythmic alpha discharges in the EEGs of the newborn.

Electroclinical features of neonatal rhythmic alpha discharges were described on the basis of polygraphic recordings from 37 newborns with seizures. The main presumptive etiological factors were perinatal hypoxia, hypocalcemia, purulent meningitis and intracranial hemorrhage. Apneic seizures were most often associated with temporal alpha discharges, whereas clonic seizures were mainly associated with central ones. Sleep cycles were abolished in half of the infants, but in those with sleep cycles, clinical seizures occurred most frequently during active sleep. Alpha discharges occurring during quiet sleep were not associated with clinical fits. The neonates who suffered from perinatal hypoxia and/or intracranial birth injury all developed abnormally, whereas those with hypocalcemia showed the most favorable outcome. Those with other etiologies demonstrated an intermediate prognosis between the two.

Alpha Rhythm↗
PubMed1982

Relationship between changes in regional myocardial contraction and energy metabolism following coronary flow reduction.

To investigate the relationship between mechanical and metabolic deterioration in the ischemic myocardium following a decrease of coronary blood flow, the patterns of regional myocardial contraction and myocardial adenosine triphosphate (ATP) content were analyzed simultaneously in canine left ventricles with constriction of the left anterior descending coronary artery (LAD). The patterns of contraction in the ischemic region were monitored by means of ultrasonic dimension gauges implanted in the endocardial surface and were classified into 5 types; Type 0 = normal, Type I = late systolic lengthening, Type II = early and late systolic lengthening with end diastolic length elongation, Type III = systolic bulge with early diastolic shortening, and Type IV = holosystolic bulge. Type I developed in 6/8 dogs with 1-49% LAD flow reduction, Type II in 6/8 dogs with 50-74% reduction, and Types III and IV in all dogs with 75-100% reduction. The myocardial ATP content (microM/Gm tissue) at the sites of the patterns of myocardial contraction measurement was analyzed. No differences in ATP content were noted between Type 0 and Type I (3.70 +/- 0.51 vs. 3.60 +/- 0.36). In contrast, the ATP content in Type II was significantly reduced (2.94 +/- 0.20) compared to Type I (p less than 0.005). In Types III + IV with systolic bulge, the ATP reductions were severer (2.59 +/- 0.36) than in Type II (p less than 0.05). In conclusion, it can be said that as the LAD flow reduction advanced, the patterns of myocardial contraction were transformed from Type 0 to Type IV with accompanying ATP reductions.

Adenosine Triphosphate↗
PubMed1982

A female case of the Leach-Nyhan syndrome.

The classical Lesch-Nyhan syndrome has the deficiency of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) activity as the result of mutation in the structural gene for the enzyme located on the X chromosome and is believed to be of X-linked recessive or sex-linked mode of inheritance. This is the first report of a girl who showed typical clinical features and biochemical characteristics of the classical Lesch-Nyhan syndrome. Her mother was not a heterozygote for a deficiency of HGPRT. Possible genetic mechanisms responsible for this case were discussed.

Adenine Phosphoribosyltransferase↗
PubMed1982

Lung function in adults with mycoplasmal pneumonia.

We prospectively studied on lung function of 17 patients (7 men and 10 women) of acute Mycoplasma pneumoniae pneumonia. Lung function tests including %VC, FEV1.0%, Peak flow, V75/HT, V25/HT, V50/V25 and MMF were measured during the acute and convalescent stage. The results showed dysfunction of peripheral airway because of reduction in V50/HT, V25/HT and MMF. It was suggested that lung function in patients with Mycoplasma pneumoniae pneumonia was impaired at the high lung volume as well as low lung volume.

Adolescent↗
PubMed1982

Seizures with apnea in children.

Five children who had apneic attacks as a manifestation of epileptic seizures are reported. In three children, the apneic attacks were the sole symptom of epileptic fits. The other two children had additional types of seizures. The apneic seizures usually lasted one to two minutes and were characterized by respiratory embarrassment rather than complete arrest. These seizures are usually accompanied by cyanosis which appears early during the course of the attack. Although consciousness seemed to be impaired, this was difficult to assess accurately in infants. The ictal EEGs disclosed paroxysmal discharges of focal onset in all cases, consisting of high amplitude theta-waves, gradually mixed with or replaced by sharp waves or spikes in some and fast waves followed by slower waves in others. These occurred in temporal areas in three patients and in frontal and central areas in one patient each. Interictal EEGs, however, revealed paroxysmal discharges in only one patient. Apneic attacks in these infants are considered to be an integral part of the manifestations of complex partial seizures originating mostly in the limbic system.

Apnea↗
PubMed1982

Brain metastasis of renal adenocarcinoma.

Among 1,828 autopsy cases of adenocarcinoma reviewed, 177 cases (9.7%) were found to have brain metastasis, and their autopsy records were analyzed to investigate the mode of dissemination of the cancer to the brain. Brain metastases were most frequent in the age group of 50-59 years but showed no significant difference in incidence between sexes or location (right or left) of the primary lesion. The cases with brain metastases had greater frequencies of metastases in the lungs, heart, thyroid and skull than cases without brain metastases. Lung metastasis was most frequent in cases with two-organ metastases, and lung metastasis with involvement of the hilar lymph nodes in cases with three-organ metastases. Metastasis to the brain was significantly more frequent in nephrectomized cases than in non-nephrectomized cases. Metastases to the contralateral kidney and peritoneum were significantly more frequent in nephrectomized cases with brain metastasis. Possible routes of dissemination of the cancer to the brain are discussed.

Adenocarcinoma↗