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Biomedical subjects

K Hall

Publications and source records attributed to K Hall.

At least 343 records · Page 19Linked to original sources
PubMed1975

Prediction of adult height of girls from height and dental maturity at ages 6-10 years.

The relationship between height and dental development was studied in 56 healthy girls by the use of the chronological age at the references point of the eruption curve of the permanent teeth. There was a high correlation between age plus height at this reference point and adult height. When growth rate was taken into account, the correlation increased. It is thus possible to predict final body height from the age at which the eruption of the first twelve permanent teeth occurs plus the height at that time. The residual standard deviation of predicted adult height was 2.3 cm.

Age Determination by Teeth↗
PubMed1975

A rapid screening test for Cushing's syndrome.

A combination test consisting of two parts, a single dose of dexamethasone and a (1-24) ACTH injection, has been used for the diagnosis of Cushing's syndrome. The test was performed by administering 1 mg dexamethasone orally at 11 p.m. on the first day and 25 IU synthetic ACTH i.v. at 8 a.m. on the second day. Plasma cortisol was determined at 8 a.m. on the first and second day and 1-1/2 and 2 hours after the ACTH injection. The test was performed in 33 patients with Cushing's syndrome and in 114 controls without adrenal disease. After dexamethasone administration alone, cortisol values frequently overlapped between patients with Cushing's syndrome and controls. The validity of the test was considerably improved by adding ACTH stimulation. The test procedure is recommended as a screening test for Cushing's syndrome in ambulatory practice.

Adrenocorticotropic Hormone↗
PubMed1975

A genetic analysis of the normal body-height growth and dental development in man.

A twin and family study on the significance of genetic factors for the variation in certain new variables of dental and body-height development is presented. Evidence of a rather strong genetic regulation of most of the variables was obtained from the analysis of the twins and sibs. The data on cousins did not allow any definite conclusions, and it was not possible to obtain a parent--offspring material. Therefore, the study did not give any information concerning the relative significance of additive genetic variation.

Adolescent↗
PubMed1975

Phenothiazine effects on cerebral-evoked potentials and eye movements in acute schizophrenics.

An investigation was made of the effects of phenothiazine medication on the averaged visual-evoked potentials (AVEP) and on eye movements in hospitalized, young, acute schizophrenic patients. These results were compared with those of normal subjects who were not given medication. AVEP measures included maximum amplitude (Am), frequency of peaks (FOP'S), variability (V) and peak latencies for an early negative peak (N1) and a later positive peak (P6). Eye movement measures included percent of time looking at a stimulus slide, percent of time looking at a figure on the slide, the number of fixations and the percent of cells entered in which fixations occurred. For schizophrenics off and on phenothiazine medication, there were no consistently significant drug effects on any measure except frequency of peaks. Schizophrenics compared to normals had lower amplitudes, greater frequency of peaks, greater variability and lower eye movement scores.

Acute Disease↗
PubMed1975

Radioimmunoassay of somatomedin B. Application to clinical and physiologic studies.

A radioimmunoassay has been developed for Somatomedin B, a growth hormone-dependent factor that stimulates DNA synthesis in human glia-like cells. The sensitivity permits detection of this factor in human plasma diluted 1: 20,000 and in monkey plasma diluted 1: 5,000. It is not measurable in nonprimate plasma diluted 1: 20. The concentration in growth hormone-deficient adult patients is equivalent to 6.6plus or minus0.5 ug/ml of a highly purified somatomedin preparation. In acromegaly the concentration is 19.3plus or minus2.3 ug/ml and falls after definitive therapy that results in a decrease in plasma growth hormone. In unextracted human plasma the immunoreactive Somatomedin B is associated with a plasma protein at least as large as gamma-globulin and with an electrophoretic mobility on paper resembling the alpha-globulins. The level of Somatomedin B in the bound form in human plasma under steady-state conditions may depend on the rate of production of the peptide and/or the concentration of the plasma-binding protein. At present there is no information concerning which of these is modulated by growth hormone. Immunoreactive Somatomedin B is found predominantly in Cohn plasma fractions III and IV, largely dissociated from the plasma-binding protein. The disappearance curves of labeled purified Somatomedin B and of immunoreactive Somatomedin B from acromegalic plasma administered intravenously to a dog were superposable; the terminal portion of the disappearance curve having a half time of almost an hour.

Acromegaly↗
PubMed1975

Immunoreactive somatomedin B in urine.

Urinary excretion by 8 normal adult subjects of immunoreactive somatomedin B was 27.6 +/- 4.4 mug between 1000 h and 1400 h compared to a mean plasma concentration at 1200 h of 5.9 +/- 0.9 mug/ml. Free somatomedin B in urine averaged 85.9%, although in the plasma of the same subjects all but less than 5% was bound to serum proteins.

Adult↗
PubMed1975

Correlation between somatomedin A in serum and body height development in healthy children and children with certain growth disturbances.

The somatomedin A level in serum was determined in a series of 66 children in whom longitudinal data on body height growth and dental development were available. The series comprised normal children as well as children with some different types of growth disturbances. A high correlation was found between the somatomedin A level and the age at a certain stage of the dental maturity (r equals to minus 0.67) and between the somatomedrin A level and the growth rate at this age (r equals to 0.67). The different groups of patients ranging from pituitary dwarfs to unusually tall children demonstrated a continuous gradient in the correlation between the level of somatomedin A and the different variables of the somatic development.

Abnormalities, Multiple↗
PubMed1975

The binding of insulin and somatomedin A to human placental membrane.

A particulate membrane fraction from human placental membrane was shown to be rich in binding sites not only for insulin but also for somatomedin A. The binding of the 125I-labelled peptide was time and temperature dependent. Degrading activity present in the membrane fraction was negligible at +4 degrees C. The Scatchard plot for insulin binding revealed two types of binding sites with an apparent high affinity constant of 3.8 times 108 M(-1) and with 5.4 times 10(-9) moles of binding sites per mg of membrane protein. The Scatchard analysis of somatomedin A revealed two classes of binding sites with an apparent high affinity constant of 2.7 times 107 M(-1) and with 1.9 times 10(-8) moles of binding sites per mg of membrane protein. In high concentrations insulin interfered with the specific binding sites for somatomedin A and vice versa. In comparison with insulin the somatomedin A preparation was one million times more potent in displacing labelled somatomedin A than in displacing labelled insulin from their respective binding sites. A radioreceptor assay utilizing particulate placental membrane and labelled somatomedin A purified on the membrane enabled the determination of somatomedin in unextracted serum. The mean values of somatomedin A in sera from patients with pituitary dwarfism and acromegaly were 0.57 and 3.2 U/ml, respectively by radioreceptor assay and 0.41 and 1.61 U/ml, respectively by bioassay. Various causes of this discrepancy between the methods are discussed.

Acromegaly↗
PubMed1975

Lipids in the mouse uterus during early pregnancy.

Lipids in the uterine endometrium of mice during early pregnancy were investigated by histochemical techniques. Three groups of animals were studied: (1) on days 1-8 inclusive of the first pregnancy, (2)on days 1-9 after mating at the post-partum oestrus and suckling seven or eight young from their first pregnancy, (3) on days 1-6 after delivery of the first litter but with no access to males. Day 1 was that on which a seminal plug appeared in the vagina or (group 3) after birth of a litter during the previous night. In post-partum mice, only the areas between the former implanation sites were studied. Epithelial lipids are sparse during the first 24 h. On day 2 and early day 3 in nulliparous mice, and for a longer period in post-partum mice, the presence of lipid in epithelium and stroma seems mainly a degenerative phenomenon associated with cell breakdown and consequent tissue disruption. During late day 3 and on day 4 the increase in lipid droplets giving staining reactions characteristic for triglycerides may represent the storage in this form of fatty acids no longer needed for phospholipid synthesis or as energy sources, once the intense mitotic proliferation of these cells dies down. Triglycerides also predominated in the necks of the glands, but in the deeper parts, the sparse droplets often gave staining reactions for acidic lipids. In differentiating decidual cells during day 5 and early day 6 in nulliparous mice, histochemical reactions suggest that fatty acids accumulate. Some of these are probably utilized in synthesis of the increasing amounts of phospholipids which were particularly prminent later on day 6 and during day 7, while others appeared to be temporarily stored during that period as triglycerides The phased deposition and removal of triglyceride proceeds centrifugally through the decidua and is slightly in advance of glycogen deposition and removal in the same cell; its time-course correlated well with that which other workers have described from chemical assay. Histochemical tests appeared to reveal activity of a lipase-esterase (fatty acid ester hydrolase) which strengthened and spread through the decidua in parallel with the disappearance of lipid droplets. In lactating mice, as long as the blastocysts remained in diapause, epithelial lipid resembled that on day 4; in the stromal cells, lipid droplets were plentiful in areas close to the former placental sites but were few or absent elsewhere. Once the delayed implantation had started no abnormalities were detected. Alterations in lipids are discussed in the context of the known changes in the levels of ovarian hormones. Lipids within uterine macrophages are also discussed.

Alkaline Phosphatase↗
PubMed1974

Somatomedin.

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Adipose Tissue↗