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Biomedical subjects

K Hall

Publications and source records attributed to K Hall.

At least 325 records · Page 18Linked to original sources
PubMed1978

Bromocriptine therapy in patients with acromegaly: effects on growth hormone, somatomedin A and prolactin.

Six of ten patients were subjectively improved by bromocriptine treatment as illustrated by diminished sweating, reduction of soft tissue swelling and restoration of sexual potency and menstruations. These six patients had elevated or normal blood levels of prolactin, which could be stimulated by TRH and inhibited by bromocriptine. During medication two clinical responders normalized and one lowered plasma GH concentrations. Three clinical responders with initially increase somatomedin A levels normalized these levels during treatment, in one case despite lack of effect on GH levels. The four nonresponders had undetectable or notably depressed levels of prolactin, which could not be stimulated by TRH. It is suggested that the presence of prolactin, per se or as an indication of a certain dopaminergic situation, is a prerequisite for successful bromocriptine treatment of patients with acromegaly.

Acromegaly↗
PubMed1978

Brain evoked potential use in a physical medicine and rehabilitation setting.

The objective of this effort was to explore the use of evoked potential (EP) procedure on a head injury unit in a Department of Physical Medicine and Rehabilitation. The method employed both auditory and visual stimulation presented bilaterally to various patients. Recordings of the brain's responses to such stimulation were obtained. Results permitted evaluation of brain stem, subcortical and cortical functioning, ipsilaterally, contralaterally, and bilaterally. EP data provided useful information for patient assessment and rehabilitation planning for head injured patients--particularly for those who were unable to cooperate in their own examination.

Acoustic Stimulation↗
PubMed1978

[Arterial and venous blood-pressure in the mesenteric circulation of rabbits with combined infusion of secretin and norepinephrine (author's transl)].

Norepinephrine and secretin were infused into V. cava inf. and Art. mesent. sup. with a short intervall and after that immediately successive on rabbits, anesthetized by urethane-chloralose; simultaneously blood-pressure was measured in Aorta abdom., Art. mesent. sup. and V. mesent. sup. Secretin alone does not change blood-pressure; infusion of norepinephrine into V. cava inf. leads to a rise of blood-pressure of about 16% in Aorta abdom., of about 12% in Art. mesent. sup.; in V. mesent. sup. blood-pressure remained unchanged. Although secretin and norepinephrine have a contrary effect on the vascular tonus with cats, in rabbits combined infusion of secretin and norepinephrine caused an increase of blood-pressure not fewer than infusion of norepinephrine alone. Possible haemodynamic mechanisms were discussed.

Animals↗
PubMed1977

Increasing growth with raised circulating somatomedin but normal immunoassayable growth hormone.

Two patients are described with elevation of circulating somatomedin A concentration but normal growth hormone levels. One,a young male, appeared clinically acromegalic; the other, a young female, was tall with kyphoscoliosis, and her appearance resembled Marfan's syndrome. In both patients plasma growth hormone concentration was suppressible by hyperglycaemia. It is suggested that their clinical syndromes resulted from excessive somatomedin activity.

Acromegaly↗
PubMed1977

Somatomedin A and B in serum from neonates, their mothers and cord blood.

Somatomedin A by radioreceptor assay and somatomedin B by radioimmunoassay were measured in serum from women immediately after parturition and from their newborns. The mean levels of somatomedin A in both mothers (0.54 U/ml) and infants (0.50 U/ml) were significantly decreased compared to a reference group consisting of 21 non-pregnant women (0.91 U/ml). There was no difference between the mothers and their children. The mean somatomedin B value in serum from the mothers (63.9 microgram/ml) was above that found in non-pregnant women (19.2 microgram/ml) and the mean value in cord blood and serum from the infants (7.1 microgram/ml) was below it. A positive correlation was noted between somatomedin A and B in cord blood; r = 0.78. The combined somatomedin A and B values in cord blood were positively correlated to birth weight (r = 0.51, P less than 0.05).

Birth Weight↗
PubMed1977

Evoked brain potentials and disability in brain-damaged patients.

Various measures of evoked brain potential abnormality (EPA) were correlated with disability ratings (DR) for 35 brain-damaged patients. EPA data consisted of judgements of abnormality of ipsilateral, contralateral and bilateral responses to auditory and visual stimuli reflecting activity in the brain stem, subcortex and cortex. DR data were obtained from a scale developed for this study to quantize and categorize patients with a wide range of disabilities from coma to normal functioning. EPA scores based on visual and auditory cortical responses showed significantly positive correlations with degree of disability. Visual response correlation was .49, auditory .38 and combined visual and auditory .51. It was concluded that EPA measures can reflect disability independently of clinical information. They are useful in assessing brain function in general and, specifically, in assessing impairment of sensory function. The evoked potential technique was particularly useful in patients who were not able to participate fully in their own examination. There were indications that the technique may also be valuable in monitoring progress and in predicting clinical outcome in brain-damaged patients.

Adult↗
PubMed1976

Binding of somatomedins and insulin to plasma membranes prepared from rat and monkey tissue.

Particulate membranes prepared from a variety of monkey and rat tissues were shown to have specific binding sites for somatomedin A. Binding to talc on the other hand showed no specificity, and the sensitivity was less. The membrane-bound somatomedin A was displaced by somatomedin A in concentrations between 0.01 and 5 U/ml. Of the other hormones tested only insulin in high concentrations could interfere with the binding of labelled somatomedin A to tissue membranes. Membranes prepared from a number of rat and monkey tissues also contained binding sites for insulin. Somatomedin A could interfere with the binding of labelled insulin. No binding was observed for somatomedin B in the tissues studied.

Animals↗
PubMed1976

Correlation between dental maturity, height development and sexual maturation in normal girls.

The correlation between the dental maturity and the different measures of sexual development, i.e. the age at menarche, the ages at breast and pubic hair development, and the age of peak height velocity, was found to be low in healthy girls. Multiple regression analyses between the predictors height and growth rate at the chronological age of a certain stage of the dental development and each of the predictands age at menarche, breast development, and age of peak height velocity improved the residual standard deviation significantly in comparison with the standard deviation of the distribution of these variables.

Adolescent↗
PubMed1976

Somatomedin A in human serum, determined by radioreceptor assay.

Somatomedin A was determined by radioreceptor assay in serum from patients with various disorders. The mean values of somatomedin A in serum from 20 adult subjects, 21 patients with acromegaly, and 17 patients with hypopituitary dwarfism were 1.08 +/- 0.08, 3.02 +/- 0.33 and 0.44 +/- 0.03 U/ml, respectively. In children below 2 years of age, low levels were found (mean 0.40 +/- 0.04 U/ml). Normal levels were found in patients with Turner's syndrome and primary hypothyroidism, increased levels in uraemic patients, and decreased levels in Laron dwarfs.

Acromegaly↗
PubMed1976

Allergy of the nervous system: a review.

Allergies of the nervous system cause diverse behavioral disturbances, including headaches, convulsions, learning disabilities, schizophrenia and depression. Some of the biological mechanisms have been established by research; others remain to be explored. Effective diagnosis and treatment include the elimination diet, followed by dietary rotation and avoidance of offending substances.

Adolescent↗
PubMed1975

Somatomedins.

Explore the source record for details and available documents.

Adipose Tissue↗