Total-body irradiation and human chromosomes. IV. Cytogenetic follow-up studies 8 and 10 1/2 years after total-body irradiation.
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Biomedical subjects
Publications and source records attributed to K Goh.
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A new aortic prosthesis (SAP, shape memory aortic prosthesis) was developed with its transfemoral placement system to treat aortic dissection with minimal invasion. The SAP consists of a Nitinol stent and polyurethane tube, and it is designed in such a configuration that it can be compressed inside a 14 Fr catheter when cold. It regains its original shape when warmed to 30 degrees C. From the results of intra-aortic sutureless placement of SAP in 10 mongrel dogs, we concluded that a SAP of proper diameter could be implanted safely for more than 3 months. The transfemoral placement system is composed of a delivery catheter, pushing rod, catching catheter, and pulling wire. Using these devices, transfemoral placement of SAP was demonstrated successfully in three dogs and one sheep. The original SAP and delivery system can be used as an emergency procedure for aortic dissections, such as Stanford type B. The advantages of the procedure are minimal invasion of acutely ill patients and prompt application in the catheter laboratory.
Treatment of various aortic aneurysms in 450 cases experienced during the past 25 years was analysed. One hundred and five patients were treated with survival rate of 80.2% in the thoracic aortic aneurysm group, 65 patients with survival rate of 76.9% in the dissected aneurysm of the aorta group, 175 patients with survival rate of 93.1% in the nonruptured abdominal aortic aneurysm group and 37 patients with survival rate of 75.7% in the ruptured abdominal aortic aneurysm group. From 1981 to the present time, considerable improvement of the operative results has been achieved with refinement of cardiovascular adjunctive techniques and operative procedures with careful management of the patients. Survival rates are now reached to 88.7% in the thoracic aortic aneurysm, 81.0% in the dissected aneurysm, 100% in the nonruptured abdominal aortic aneurysm and 81.2% in the ruptured abdominal aortic aneurysm. From the careful analyses of the results, prompt diagnosis, distinct treatment policy, strict operative indication and better surgical procedure are considered to have contributed to these excellent operative results.