Letter: Herpes labialis and multiple sclerosis.
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Adult↗
Biomedical subjects
K G Warren
Publications and source records attributed to K G Warren.
Computer tomography in disseminated sclerosis.
A case is reported where the appearance of acute, diffuse, disseminated sclerosis on computer tomography (Ct scan) is described and the literature is reviewed. This disease may give rise to multiple, small areas of diminished X-ray absorption which may decrease in size during the course of the disease. The histological features of one of the lesions was correlated with the radiological findings. It is suggested that, perhaps, only during the active stage of demyelination can the lesions be detected on the Ct scan.
Adult↗
Neuronal and lymphocytic populations in human trigeminal ganglia: implications for ageing and for latent virus.
The number of neurones and of lymphocytes was determined morphometrically in serial sections of trigeminal ganglia harvested at autopsy from 64 human subjects dying at ages 2 months to 81 years. The nerve cell population varied from 20 159 to 156 702 with a mean of 80 638 /ganglion and was unaffected by increasing age. The degree of lymphocytic infiltration, which was prominent and ubiquitous, also did not correlate with the subjects' age. There was no significant correlation between neuronal and lymphocyte counts. The inflammatory cells present throughout life apparently are unassociated with any detrimental effect upon the sensory neurones, and may represent a histopathological marker either of reactivating herpes virus or of virus maintained in a latent state within the Gasserian ganglia of man.
Adolescent↗
Geographic and temporal distribution of mortality rates for multiple sclerosis in Canada, 1965-1994.
Statistics Canada data were used to calculate multiple sclerosis (MS) mortality rates per 100,000 population in the Canadian provinces from 1965 to 1994. For the period 1965-1994, the highest average annual MS mortality rates were in Quebec (4.4) and Ontario (3.9), while the Western Provinces had an intermediate rate (2.1) and the Atlantic Provinces had the lowest rate (1.2). Female mortality rates exceeded male rates in each of the four regions. Average annual MS mortality rates in Canada overall fluctuated during the past 30 years, with rates of 3.4 in 1965-1969, 4.2 in 1970-1974, 3.2 in 1975-1979, 2.3 in 1980-1984, 2.8 in 1985-1989 and 3.9 in 1990-1994. Female mortality rates exceeded male rates during each 5-year period. The highest mortality rates for both genders were in the 65 years plus age group. Rates in the under 45 years age group have remained stable, while rates in both the 45-64 and 65 years plus age groups have fluctuated. There is no apparent relationship between prevalence and mortality rates among the Canadian provinces.
Adult↗
Parental ancestry and risk of multiple sclerosis in Alberta, Canada.
Self-reported population ancestry data for the 19 census divisions (CDs) of Alberta, Canada, were correlated with multiple sclerosis (MS) prevalence rates in those divisions, for men and women separately; and parental ancestry was compared between a group of MS patients and controls attending the University of Alberta MS Clinic. At the CD level, there was a positive correlation between single Scandinavian ancestry and MS prevalence in men, but this was not confirmed in the case-control comparison. The case-control comparison indicated an excess risk of MS associated with single non-specific European as opposed to British ancestry in men only. When paternal versus maternal ancestry was considered separately, there was an excess risk of MS associated with non-specific European as opposed to British ancestry for both men and women, but on the father's side only. Aboriginal ancestry was negatively associated with MS prevalence at the CD level in both men and women; and no MS patients with aboriginal origin were among cases assembled through the MS clinic.
Canada↗