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Biomedical subjects

K Fukuda

Publications and source records attributed to K Fukuda.

At least 973 records · Page 54Linked to original sources
PubMed1980

Ultrastructral changes induced by 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea in L1210 lymphocytic leukemia cells in mice.

Ultrastructural changes in L1210 leukemic cells infiltrated in the sinusoid of mouse liver after treatment with a single dose of a newly developed antitumor agent, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride, were observed by electron microscopy. In the earliest stage after injection of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride in tumor-bearing mice, marked changes were observed in both nucleolar and cytoplasmic ultrastructures. At 48 hr after administration, numerous Golgi complexes were observed in the cytoplasm, and lysosome-like granules also increased. The most striking change after treatment with 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride, however, occurred in the nucleolus. The chromatin was condensed, tending to collect near the nuclear membrane. Segregation of the nucleolar constituents was observed in the nucleus. Many necrobiotic cells were also observed within the liver sinusoid at this stage.

Animals↗
PubMed1979

Clinical application of computed tomography to thyroid disease.

CT examinations were carried out in 62 patients with various thyroid disorders, 42 patients with thyroid nodules, 12 with diffuse abnormality and 8 of others. Evaluation was made whether CT could provide more information compared with other techniques. Cystic thyroid nodules could be differentiated from solid nodules with a reasonably high degree of accuracy. Uncalcified thyroid carcinoma was noticed as an ill-defined nodule with irregular wall, grossly the same in density with the muscle in plain CT, and not opacified by contrast material. CT has the ability to define the nature of the thyroid nodules better than other nontraumatic diagnostic modalities.

Adenoma↗
PubMed1979

Histopathological study on the conduction system of complete right bundle branch block with references to configuration of QRS complex.

Eleven autopsy cases (average of 71 years) with complete right bundle branch block were examined histologically with serial sectioning of the conduction system. The results were as follows: 1) moderate to severe reduction of conducting cells in the right bundle branch (RBB) by fibrous replacement in all 11 cases, 2) a preponderance of main lesions in the first portion of the RBB in cases with R configuration in leads V1 and V2, and in the second to the third portion without significant lesion of the Purkinje cell network in the right ventricle in cases with rsR', and RSR' configuration in these leads, 3) as to the etiology, 1 case was assumed to have had rheumatic myocarditis and an another case, 1 chronic ischemia. In cases in which the cause could not be clearly established, reduction of the conducting cells in the first portion of the RBB was thought to be due to fibrosis of the upper ventricular septum. Lesions in the second portion of the RBB may be due to mechanical strain effected by muscle crossing of the trabecula septomarginalis and RBB.

Aged↗
PubMed1979

Incidence and etiology of lung cancer in the Pacific Basin.

Incidence of lung cancer in the Pacific Basin was either compiled from published reports or computed by the authors. The results showed a great variation in age-standardized annual incidence rates of lung cancer among 10 countries and 17 areas in the Pacific Basin where tumor registry statistics are available. For males the incidence rates ranged from 10 to over 70 and for females from less than 5 to over 30/100,000 population. The reason(s) for the great variation is unclear. Ionizing radiation, carcinogenic chemical substances (e.g., chromium, arsenic compounds, asbestos, etc.), or air pollution are unlikely to be responsible. Because cigarette smoking is known to be a major cause of lung cancer, the authors have suggested that surveys on cigarette smoking be conducted among various populations in the Pacific Basin so that etiologic significance of cigarette smoking for the noted variation can be assessed. In Hawaii such a survey is underway, and a preliminary analysis was made to examine the association between lung cancer and cigarette smoking among five races.

Australia↗
PubMed1978

3-O-Methyl galactose found in polysaccharides of Lampteromyces japonicus.

A polysaccharide fraction from Lampteromyces japonicus contained a sugar (4%), which was identified as 3-O-methyl galactose by demethylation with boron trichloride, periodate oxidation of the methyl glycoside derivative and gas chromatography-mass spectrometry of the alditol acetate derivative.

Chromatography, Gas↗
PubMed1978

Circles in spermatocyte chromatin loops. Electron microscopy and AgAs-NORs studies.

We describe the production of circles in chromomeric loops during the pachytene stage of the spermatocytes. These circles are found attached to chromatin or already free in the nucleoplasm. Each circle measures an average of 3700 A in circunference. We suggest that such circles might indicate the presence of tandem repetitions.

Animals↗
PubMed1978

Purification and chemical characterization of polysaccharides obtained from Lampteromyces japonicus by concanavalin A-sepharose affinity chromatography.

Two classes of neutral polysaccharide which could not be separated from each other by conventional methods were isolated from the fungus, Lampteromyces japonicus, by affinity chromatography using concanavalin A-Sepharose. The polysaccharide retained on the concanavalin A-Sepharose column was eluted with 0.05 M methyl alpha-D-mannopyranoside and appeared to be alpha-mannan, while that which passed through the column was virtually all beta-glucan. Both polysaccharides were subjected to Smith-type degradation, methylation, acetolysis and glucosidase treatment. The results indicated that the alpha-mannan contained predominantly alpha-(1 leads to 2)-linked side chains branching from an alpha-(1 leads to 6)-linked backbone at the (1 leads to 2,6)-linked mannopyranosyl residues. Galactose was attached to approximately one-quarter of the non-reducing mannose terminals. The beta-glucan seemed to contain mainly (1 leads to 6)-linked side chains branching from a (1 leads to 3)-linked backbone at the (1 leads to 3,6)-linked glucopyranosyl residues.

Agaricales↗