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Biomedical subjects

K Friedrich

Publications and source records attributed to K Friedrich.

103 records · Page 6Linked to original sources
PubMed1979

[Spontaneous and DL-penicillamine-induced renal copper excretion in liver diseases (author's transl)].

The levels of cupriuresis before and after DL-Penicillamine have been investigated in 168 cases. The mean copper excretion before Penicillamine in chronic activ liver disease, chronic persistant hepatitis, cirrhosis and in transitional cases of aggressiv chronic hepatitis and primary biliary cirrhosis ranged from 29 gamma to 48 gamma/24 hr.; however, in some cases the daily copper excretion exceeds 100 gamma, as well in subjects with liver disease as in normals too. After ingesting 900 mg DL-Penicillamine the mean values of cupriuresis ranged from 500 gamma to 600 gamma/24 hr. Abnormal results were found in about 15% of those subjects with liver diseases; in only two of 20 cases with hypercupruria after Penicillamine Wilson's Disease was established.

Copper↗
PubMed1977

[Complications after ambulatory oral surgical interventions, their frequency and importance].

The rate of complications of the healing process observed during or after oral surgical intervention on an outpatient basis amounts to 9.75% of the cases. Most frequently occur tooth-root fractures, alveolitis/osteitis, osteomyelitis, soft-tissue infections, haematomas, postoperative bleedings, antral perforations, sinusitis and perception disorders. The great medical and economic importance of such complications is pointed to on the basis of personal results and relevant data from the literature. An improvement in treatment results can be aimed at by reducing the rate of complications as well as by shortening the duration of treatment. Some relevant suggestions are given.

Alveolar Process↗
PubMed1977

Conversion of proinsulin into insulin by cathepsins B and L from rat liver lysosomes.

Conversion of proinsulin and intermediate forms of proinsulin into insulin were studied with rat liver cell fractions and purified lysosomal proteinases by using the technique of polyacrylamide disc-electrophoresis. Both substrates were degraded very rapidly by homogenates and crude lysosomal fractions to split products not detectable on disc-electropherograms. Neither breakdown nor conversion were detected with the cytosol and the microsomal fraction. With partially purified lysosomal fractions (mol. wt. approx. 25 000) or with highly purified cathepsin L or cathepsin B (B1) proinsulin was converted into products migrating like the intermediate forms and insulin, and the intermediates were converted into products migrating like insulin and deoctapeptide-insulin in disc-electropherograms. The mechanism of conversion seems to be different for both enzymes. The results force us to conclude that lysosomal cathepsins, especially cathepsins L and B might be involved in the process of conversion of proinsulin into insulin and perhaps also of other precursors into biologically active proteins in vivo.

Animals↗
PubMedDate not supplied

Detection of tumor cells in peritoneal lavages from patients with gastrointestinal cancer by multiplex reverse transcriptase PCR.

BACKGROUND/AIMS: Cytological examination of peritoneal lavages is a useful predictor of peritoneal recurrence in gastrointestinal carcinoma patients. Nevertheless, it may be inadequate for those patients with lavages containing only few cancer cells. In the present study, sensitive detection of free cancer cells could be achieved through amplification of cytokeratin 19, carcinoembryonic antigen, alpha-fetoprotein mRNAs by means of multiplex reverse transcriptase polymerase chain reaction and nested polymerase chain reaction. METHODOLOGY: The multiplex reverse transcriptase polymerase chain reaction assay was used to examine lavage samples from 64 patients with various gastrointestinal malignant lesions (colorectal n = 27; duodenal carcinoma n = 1; gastric n = 7; pancreatic n = 4; hepatocellular carcinoma n = 2; gallbladder n = 1; cholangiocellular carcinoma n = 2 and 20 colorectal liver metastases. Specificity was assessed by examination of 15 donors without malignancies. In addition, nested polymerase chain reaction was used to improve the sensitivity of the assay for the detection of alpha-fetoprotein transcripts. RESULTS: Peritoneal lavages from 12 of 64 gastrointestinal carcinoma patients were positive for carcinoembryonic antigen mRNA. Carcinoembryonic antigen proved a specific marker, as no false-positives were detected in any patients without gastrointestinal cancer. alpha-fetoprotein mRNA was detected exclusively in peritoneal lavages from tumor patients, i.e., in 16 of 27 colon cancer patients, 14 of 20 patients with colorectal liver metastasis, 2 of 7 patients with gastric cancer, two patients with hepatocellular carcinoma and 2 of 4 patients with pancreatic cancer. Cytokeratin 19 mRNA was not found a useful marker, since control patients without malignancies were also positive. CONCLUSIONS: Our data suggest that carcinoembryonic antigen- and alpha-fetoprotein mRNA in peritoneal lavage are potentially useful specific markers for early diagnosis of metastasis of gastrointestinal cancer. It has been shown that alpha-fetoprotein-specific nested reverse transcriptase polymerase chain reaction can detect not only hepatocellular carcinoma cells, but also malignant cells from other gastrointestinal carcinomas. In contrast, cytokeratin 19 mRNA lacks specificity for gastrointestinal cancer.

Biomarkers, Tumor↗
PubMedDate not supplied

[Spatial pattern and consequences of demographic aging processes for regional planning].

The spatial dimension of man-environment interactions in old age is analyzed within urban, suburban, and rural residential environments of the German Rhine-Main-Agglomeration. By comparing the three levels of organization, utilization, and interpretation, housing conditions as well as geographical distribution and redistribution (migrations) our outside-home-activities and environmental perception show a fundamental influence on the everyday lives of the 750 elderly who were interviewed. The majority of the target population and, especially, the rural elderly is characterized by traditional patterns of spatial organization and distribution, mobility, regional attachment, and a concern about preserving the stability of their current residential environment from changes. The suburban and urban seniors, however, exhibit a greater amount of locational flexibility and utility-oriented behavior patterns. These spatial variations are induced by specific regional values and intensity of local and regional identification. They might be interpreted as different stages in the process of modernization within postindustrial societies. Reflecting, however, the paradigms of planning for the elderly, these different patterns are not systematically considered to the necessary and sufficient extent. Instead of promoting regional or local networks that are favored by senior citizens, agencies usually prefer comprehensive approaches on a macrolevel. First steps to improve this situation and to combine life- and system-world demands have been taken by the federal government, which implemented a neighborhood-related research program on housing for the elderly. As a result of this, further research on environmental aspects on aging should pay more methodological attention to the hitherto neglected regional and local level, and also for the transfer of its findings into planning policy.

Aged↗
PubMedDate not supplied

[Residential mobility in the elderly. Current results of geographic mobility research in unified Germany].

Elderly migrations are often considered as amenity-oriented long distance moves or as decisions for a change by moving into homes for the aged. The intention of this contribution is to prove the validity of these assumptions in the light of actual results of migration research in unified Germany. The findings of the spatial pattern of internal migrations as well as the characteristics of the migrants and their reasons underline the necessity of more differentiated considerations. They neither prove the relationships between migration participation and the available personal resources, nor the assumption that elderly migrants usually prefer long distance moves to attractive regions. Due to this, the relocations into institutions or retirement areas together only represent about one third of all migrations. The majority leaves their community and migrates to kin-oriented networks when they feel they are not able to manage their living conditions by themselves. Beside this exogenous reasons within the housing environments or the housing demands of the ethnic germans from eastern Europe force elderly to decide to move.

Aged↗