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Biomedical subjects

K Friedrich

Publications and source records attributed to K Friedrich.

At least 91 records · Page 5Linked to original sources
PubMed1988

[Cyclosporin A in chronic active hepatitis. Results of a pilot study of 20 patients].

In 20 patients suffering from advanced chronic active hepatitis, type B or NANB, the therapeutic effect of cyclosporin A was studied. 15 of these patients already showed cirrhotic transformations and partial liver dysfunctions. In 15 cases an unsuccessful pretreatment with glucocorticoids and/or azathioprine had been performed. Only 3 patients showed an improvement of biochemical and morphological findings under treatment with cyclosporin. In spite of complete normalisation of the biochemical data in another case the morphologic aspects of a liver biopsy remained unchanged. Except for one case of obvious hepatoxicity no serious side effects of cyclosporin were observed under a therapeutic blood concentration between 200 and 400 ng/ml. From our observations we conclude that cyclosporin only in rare cases of advanced chronic active hepatitis may be promising. Furthermore we could not detect any particular criteria for predicting a response to cyclosporin in advance.

Cyclosporins↗
PubMed1987

[Cardiovascular diseases in exposure to the saltpeter acid ester ethylene glycol dinitrate].

By means of the establishment of constituents of explosives on the basis of the measuring technique the exposition intensity to ethylene glycol dinitrate in the mining industry could be recognized. By comprehensive clinical and paraclinical differential-diagnostic examinations as a consequence of this haemodynamically greatly effective exposition manifest disturbances of the cardiac rhythm were objectified in 8 workers and acknowledged as occupational disease Nr. 27.

Adult↗
PubMed1987

[Laparoscopic hemostasis following liver biopsy by instillation of a gelatin cartridge].

In 1981 Dagnini introduced his bio-plug-system for laparoscopic blood coagulation. This procedure represents a valuable new technique in case of bleeding or cholorrhea after liver biopsy. In more than 85% serious bleeding events could be managed successfully. In cholorrhea we have very limited experience since we have treated only three cases so far - one without success. In spite of our good results we feel that even in the future the proven techniques of blood coagulation, i.e. instillation of thrombin and electrocoagulation, for the management of complications under a laparoscopy should be kept at hand. In case of a failure the bio-plug-procedure can barely be repeated.

Biopsy↗
PubMed1986

Ultrasound in cholangiofibromas of the liver detected by laparoscopy.

We investigated the question as to whether benign cholangiofibromas of the liver (biliary microharmatomas) show specific structures in ultrasound. Patients with single, sporadic, multiple or diffuse cholangiofibromas (n = 53), detected by laparoscopy and verified by histology, were examined by ultrasound. The single and sporadic type (n = 30) could not be detected by US. In patients with the multiple and diffuse type (N = 23) the descriptive US finding was: "increased content of fibrous tissue, cirrhotic transformation possible". Thus we conclude that patients with non-specific alterations of the liver in the ultrasound image must undergo further investigation by laparoscopy. Blind biopsy is not capable of verifying the presence of cholangiofibromas.

Adenoma, Bile Duct↗
PubMed1986

[Value of laparoscopy in the diagnosis of chronic nonsuppurative destructive cholangitis].

39 female and 5 male patients with chronic non-suppurative destructive cholangitis (CNDC), excluding cases with the complete picture of a primary biliary cirrhosis, were examined. Besides clinical and immunological investigations in all patients laparoscopy was performed, in 18 cases repeatedly in order to control the course. As typical laparoscopic appearance in 43 of the cases we saw geographically outlined and generally communicating areas on the liver surface within somewhat brighter surroundings ("map-like-phenomenon"). Besides this a darker coloration in the center of the liver lobules was significant ("leopard skin-phenomenon"). Regarding the size, the consistency, the shape of the edge, and the structure of the surface of the liver we determined different stages of the disease. Our scale showed a good correlation to the copper-content of the liver, but did not always correlate to Scheuer's histological scheme. The significant uncertainties of histopathological interpretations of the findings in early stages of CNDC as well as differential diagnostic considerations are discussed. According to our results we believe that laparoscopy can significantly contribute to solve the diagnostic problems.

Adult↗
PubMed1984

[Laparoscopy findings of the yellow spot, a focal fatty liver infiltration].

From 1976 to 1982 in 279 patients amongst 3719 laparoscopies focal fatty liver infiltrates were found at the right and/or left liver edge next to the insertion point of the round ligament. These so-called "yellow spots" mainly could be recognized in case of normal liver tissue and in cases suffering from chronic hepatitis insofar as a cirrhotic transformation or a significant fibrosis had not taken place. The localization and the shape of these focal lesions indicate, that an abnormality in the portal blood supply of the corresponding area may play an etiologic role for the development of the fatty infiltration.

Fatty Liver↗
PubMed1984

[Error magnitude of measurement sensors in air segment plethysmography].

Besides examining the properties of the material involved, this investigation assesses the so-called static and dynamic measurement errors of sensors used for air segment plethysmography. The static error which has been found with the new BN sensors amounts to 8% (old models: 31%-44%). The folding of the interior membrane of the sensor resting upon the skin, which increases proportionately to the stiffness of the material, is discussed as a source of error. If a lockable steel wrapping is employed as an exterior cover for the sensors, the static measurement error decreases by 30%-50%. These results suggest a recommendation to use a metal wrapping for the sensors as described above even with routine air segment plethysmographic examinations, and additionally to correct by mathematical means the static measurement error (which has to be determined for each sensor individually). The measurement error of the sensors of the new BN series amounts to less than 5% for a frequency of not more than 0.5 Hz; this means that blood flow values amounting to more than 50 ml/(min X 100 ml) are indicated correctly with respect to the actual frequency. If the usual linen covering is used instead of the steel cover, the linearity of the frequency is only valid up to 0.1 Hz--the corresponding blood flow value being 15 ml/(min X 100 ml).

Diagnosis, Differential↗
PubMed1982

[Laparoscopic aspect and clinical relevance of cholangiofibromas].

In a current series of 1160 laparoscopies in 38 cases (3.2%) we found cholangiofibromas. The picture of single, sporadic and multiple cholangiofibromas as well as cholangiofibromatosis is both described and documented by laparoscopic photography. Clinically it seems remarkable that only patients with alcohol- or drug-induced liver injury showed such alterations. The prevalence of cholangiofibromas in toxic liver damage suggests that we are here not dealing with embryonal aberrations (hamartomas) but apparently with cellular inductive phenomena.

Adenoma, Bile Duct↗
PubMed1982

[The risk of virus transmission and morbidity in sexual partners of HBeAg positive patients with chronic liver disease (author's transl)].

Sexual partners of 50 HBeAg positive patients suffering from chronic HBV-induced hepatitis were investigated for signs of HBV-transmission or morbidity. 80% of the partners have been infected. 90% of these developed immunity against HBV; 10% acquired an acute or chronic hepatitis B. We were unable to establish any predominant criteria favoring the infection. Sexual activity, in particular, in our opinion is not of paramount significance.

Adolescent↗