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Biomedical subjects

K Edwards

Publications and source records attributed to K Edwards.

50 records · Page 3Linked to original sources
PubMed1976

Biosynthesis of albumin via a precursor protein in Morris hepatoma 5123tc.

The mechanism of albumin biosynthesis was studied in Morris hepatoma 5123tc in vivo and in hepatoma cell suspensions obtained by solubilizing the intercellular matrix with collagenase and hyaluronidase. In the in vivo experiments, L-[-14C]leucine was injected i.v. into rats bearing hepatomas in the muscles of both hind legs. After 14 min, tumors were removed and homogenized. A protein fraction quantitatively precipitable with antialbumin was isolated from the homogenate by acetone fractionation and precipitation with antiserum against serum albumin. This protein fraction was not homogeneous. With the use of 3 consecutive chromatographies on diethylaminoethyl cellulose, a very highly radioactive albumin-like protein could be separated from a large amount of only slightly radioactive albumin. In hepatoma cell suspensions incubated with L-[1-14C]leucine followed by a chase with excess nonradioactive L-leucine, radioactivity was incorporated first into the albumin-like protein and transferred thereafter into albumin, suggesting that albumin was synthesized via the albuminlike protein as precursor. In vivo, 1.8% of newly synthesized hepatoma protein was albumin or its precursor, compared with 1.2% in cell suspensions.

Albumins↗
PubMed1975

The effect of triazolam on the sleep of insomniacs.

The effects of three oral doses of bedtime triazolam (0.25 mg, 0.5 mg, and 1.0 mg) a new benzodiazepine, on the laboratory sleep of insomniacs were studied in a double blind design which used the following 14 consecutive night schedule: 1-4 placebo; 5-11 drug; 12-14 placebo. Effects on sleep were measured objectively by conventional EEG/EOG/EMG sleep recordings and subjectively by questionnaires administered each morning. Side or toxic effects were assessed by screening physicals and questionnaires administered each morning and each evening and by a comparison of the prestudy vs. end-study physical exams and clinical lab tests. At the 0.5 mg dose triazolam significantly reduced several objective and subjective measures of insomnia. It had lesser effects at the 0.25 mg dose and equal or greater effects at 1.0 mg dose. There were no remarkable side or toxic effects at any dose.

Adult↗
PubMedDate not supplied

The modified clove hitch: a technique to maintain endotracheal tube position in the intubated patient.

We describe the technique of using a modified clove hitch made of nasal cannula tubing as a means of insuring the position and security of an endotracheal tube in the intubated patient. Our experience indicates that this tie works well in both the prehospital and emergency department settings. We suggest that the modified clove hitch is a valuable adjunct to emergency airway management.

Airway Obstruction↗
PubMedDate not supplied

Postoperative patient-controlled analgesia in children.

Patient-controlled analgesia (PCA) has been found to be an effective method of pain management for adults. Children are now being considered for self-administration of analgesia. With careful patient selection and preparation, nurses and children find patient-controlled analgesia to be an effective way to maintain comfort in the postoperative period.

Analgesia, Patient-Controlled↗
PubMedDate not supplied

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Health Facilities↗