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Biomedical subjects

K Ebeling

Publications and source records attributed to K Ebeling.

At least 91 records · Page 5Linked to original sources
PubMed1984

[Screening for endometrial carcinoma in a group at risk].

In a population-based study 923 asymptomatic women with diabetes aged 40 to 70 years were investigated by aspiration curettage. The samples were evaluated histologically. During the initial screening 4 histologically proved endometrial cancers were diagnosed. All cancer patients were additionally obese and had hypertension, with one exception they were also nulliparous. During the same period the expected number of cases for all investigated women was estimated to 0,74. The expected number of cases limited to those with diabetes, obesity and hypertension was 0,31; and limited to those with diabetes, obesity, hypertension and nulliparity was 0,1, respectively. Additionally 4 cases of adenomatous hyperplasia of the endometrium were identified. The long-term impact on morbidity and mortality of endometrial cancer within the investigated population at risk cannot be assessed as yet.

Adult↗
PubMed1984

[Malignant neoplasms of the ovary in Berlin, capital of East Germany, 1975-1979].

Some data characterizing the situation in ovarian cancer control in Berlin, capital of the GDR, during the period 1975-1979 were analyzed. The analysis demonstrates a slight decline of the age-standardized incidence rate to 19,9/100 000. Only 23% of all cases were detected in stage I. 65% of the patients had advanced tumors of stages III or IV. There was an increase of patients treated with radical surgery up to the age of 65 years. The 5-year-survival rate amounted to 21% and was strongly related to the age of patients and the tumor stage.

Adolescent↗
PubMed1983

[Screening in gynecologic oncology].

Practical value of screening depends on various characteristics of cancers themselves, suitable tests and programs being able to cover a sufficient part of the population. Cancers favourable for screening are those with a high prevalence in the population screened, a detectable preclinical stage and better treatment results if detected by screening than detected by symptoms. Suitable screening tests have to be highly sensitive and specific, simple, cheap and without any risk. Before the widespread application of a screening program as a public health measure scientific basis and rational organization should be well known and the benefit has to be evident. Cytological screening is the most effective measure in cervical cancer control. Screening also promises a reduction in mortality from breast cancer, but further evaluation is necessary before decisions can be made about the application as a public health measure. Selective screening is probably connected with an improved health care for high risk persons of endometrial cancer. Follow up with HCG-RIA after hydatidiform mole improves early detection and prognosis of trophoblastic neoplasias significantly.

Adult↗
PubMed1983

[Bronchial carcinoma in Berlin, capital of East Germany 1975 to 1979].

Some important data characterizing the situation in lung cancer control were analyzed in Berlin, capital of the German Democratic Republic, during the period 1975-1979. The incidence rates amounted to 91.9/100 000 in men and 20.5/100 000 in women. The incidence is higher in the capital Berlin than in the GDR as a whole. Lung cancer patients were mostly treated by radiation therapy (19.7%) or surgery alone (16.6%). The cumulative relative 5-year-survival rate of patients treated in 1975/76 amounted to 10.3%. Primary prevention by consequent reduction of tobacco consumption rates, especially in younger people, would be the most important contribution to reduce lung cancer risk and seems to be more effective than secondary prevention. The reduction of exposition against cancerogenic factors, the control of exposed people and chest X-ray examinations of persons at high risk are further contributions to improve lung cancer control.

Adolescent↗
PubMed1982

Radical pelvic surgery versus radical surgery plus radiotherapy for stage Ib carcinoma of the cervix uteri. Preliminary results of a prospective randomized clinical study.

In a preliminary report of a prospective controlled study treatment results and therapy morbidity of 60 patients with stage pT1bNoMo carcinoma of the uterine cervix treated by radical surgery only (Wertheim-Meigs) were compared with those of 60 patients treated by radical surgery followed by a postoperative external radiotherapy. The median duration of follow-up was 44 (24--72) months. Comparing the survival probability analyzed by life-table-method up to 18 months there was a significant better result for patients treated with surgery only. However, after that the study demonstrated comparable therapeutic results with the two therapeutic regimens. There was no difference of tumor size in patients who died after surgery alone and those who died after combined therapy. The therapy morbidity was slightly greater in patients treated by combined therapy. Especially lymphedemas of the leg developed more frequent in patients treated with combined surgery and radiotherapy. Preliminary analysis of the study does not demonstrate any beneficial effect of postoperative radiotherapy followed a radical hysterectomy with pelvic lymphonodectomy in cervical cancer stage pT1bNoMo, but optimal staging, radical surgery and carefully histological examination of the removed tissue are essential needs for this approach.

Adult↗
PubMed1982

[Malignant neoplasms of the uterus in the capital city of East Germany, Berlin, in the period from 1975 to 1979].

Some important data characterizing the situation in endometrial cancer control during the period from 1975 to 1979 in the capital of the German Democratic Republic, Berlin were analyzed. The analysis demonstrates a further increase of the standardized incidence rate to 23.2/100,000. The increase is strictly limited to the age-groups between 65 and 80. The mortality rate decreased to 7.3 100,000. Further progress in endometrial cancer control can be demonstrated by an increase of cases detected in stage I (68%) and a significant increase of the 5-Year-Relative-Survival-Rate (1965 to 1968: 69%/1975-76: 77%). During the period analysed there was an marked increase of patients treated by radical surgery or radical surgery plus radiotherapy and a decline of patients treated by radiotherapy alone. Some conclusions are drawn concerning the further improvement of prevention, early detection and treatment of endometrial cancer.

Adult↗
PubMed1982

[Malignant neoplasms of the breast in the capital of the German Democratic Republic, Berlin, 1975-1979].

Some important data characterizing the situation in breast cancer control were analyzed in the capital of the German Democratic Republic, Berlin, during the period from 1975 to 1979. In comparison with former periods a progress is demonstrated by a decrease of the diagnostic interval, an increase of stages I and II (73%), an increase of patients treated with radical surgery (85.1%) and an improvement of the relative 5-year-survival rate (67.8% of all stages and age groups). The relative 5-year-survival rate is significantly higher in patients treated in a comprehensive cancer centre with strictly multidisciplinary treatment (75.8%) than in those treated in all other hospitals (63.5%). For patients treated in hospitals with less than 20 new cases per year the survival rate is significantly lower (59.4%), especially for the advanced stages III and IV. Further progress in breast cancer control can be expected by improvement of early detection, centralization of treatment in hospitals with specialized oncological team work and a well organized follow-up system.

Adult↗
PubMed1981

DNA distribution patterns of preneoplastic cells and their interpretation. Stomach and cervix uteri.

Gastric mucosa and smears of the cervix uteri - both under normal conditions and in different pathological stages - were processed by flow cytometry. DNA distribution patterns were measured and compared. Special interest was focused on chronic atrophic gastritis (CAG), checking its biological value and clinical importance with precancerous stages of the cervix uteri. In rare, distinct cases, CAG revealed carcinoma indicating DNA distribution patterns as distinct cases of dysplasia and Ca in situ of the cervix.

Biopsy↗
PubMed1981

[Antineoplastic chemotherapy for cervical carcinoma (author's transl)].

The effectiveness of antineoplastic substances on cervical carcinoma is insufficient. While combined chemotherapy was found to be more effective than monotherapy, satisfactory results were not achieved either. When it comes to recurrent or metastatic cervical carcinoma, antineoplastic chemotherapy, therefore, is not recommended unless all surgical and radiotherapeutic means have been tried with no success. Benefit to the patient and expected molestation should be carefully weighed, before a decision is made.

Bleomycin↗
PubMed1981

[Problems of radiotherapy in radically removed cervix cancers in stages T1b NO MO. Preliminary results of a randomized clinical trial].

A prospective controlled study was undertaken for the purpose of establishing the usefulness of postoperative radiotherapy following radical surgery of cervical carcinoma, Stage pT1b NO MO. A random selection was made of 120 patients who were either treated exclusively by radical surgery (Wertheim-Meigs) or in whom radical surgery was followed by postoperative telecobalt irradiation of the minor pelvis 50 to 52 Gy). No significantly difference were found to exist between the two therapeutic approaches, after an average period of follow-up observations of 33 months (between twelve and 60 months). The incidence of lymphoedema was increased with significance in those patients who had been irradiated.

Clinical Trials as Topic↗
PubMed1981

[Epidemiology of cervical carcinoma and screening activities in GDR (author's transl)].

In the GDR, cervical carcinoma is considered as one of the most important malignant neoplasias for its high incidence and age distribution. It offers, however, optimum prerequisites for effective cytological mass screening for primary and secondary prevention. Reference is made to typical screening effects in an attempt to analyse activities for early diagnosis which are highly differentiated by regions within the GDR. Systematic expansion of capacities for cytological examination is essential to the control of cervical carcinoma. Medical attention can be further improved by wider use of specialised prebioptic diagnosis in connection with all suspicious and positive screening findings.

Age Factors↗
PubMed1981

[Screening for prevention and early detection of cervical cancer in the German Democratic Republic-- an analysis (author's transl)].

The cytological mass screening to prevent invasive carcinomas by detection and therapy of intraepithelial neoplasia and to detect early stages of invasive carcinomas is the most important basis for cervical cancer control. An analysis of epidemiological effects caused by mass screening programs in two districts (Berlin, capital of the GDR; Rostock) demonstrates during the last 7 years a marked increase of detected ca in situ followed by a clear decrease, a decrease of morbidity of cervical cancer (49.4/100,000 :36.1/100,000 women) and an increase of earlier stages, especially stage Ia. The highest decrease of morbidity could be observed in women aged 40--49 years (111.6 : 61.0) followed by those aged 50--59 years (91.1 : 76.1). Preliminary results demonstrate the benefit of screening program and the practicability of organization form used in the capital Berlin. A further analysis demonstrates screening activities in the whole country. a continuous increase of cytological capacities in many districts is the remarkable result of the activities and gives the assurance for further success of the cytological screening program decided for the German Democratic Republic.

Adult↗
PubMed1980

Recent results of early detection of gynecological cancer in the German Democratic Republic.

The scientific basis, current activities and recent results with the detection of the most important malignant gynecological tumors are demonstrated. On the basis of the results obtained we hope to make further progress in preventing cervical cancer by intensifying cytological mass-screening in the whole country. Testing high-risk-concepts of endometrial cancer can improve the early diagnosis of women being examined prophylactically. But for carcinoma of the ovary there does not exist a realistic basis for any decisive progress today.

Adenoma↗