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Biomedical subjects

K E Andersen

Publications and source records attributed to K E Andersen.

At least 181 records · Page 10Linked to original sources
PubMed1984

The dialysis catheter and infectious peritonitis in intermittent peritoneal dialysis.

118 episodes of infectious peritonitis registered among 156 patients treated with intermittent peritoneal dialysis over a 5-yr period were analysed with special reference to potential routes of infection associated with the dialysis catheter. Peritonitis was randomly distributed among the patients, and the change of keeping free of peritonitis declined exponentially with time. The main factor determining the individual number of episodes was the total space of time, in which a patient had been wearing a dialysis catheter, whereas the number of catheter disconnections played no significant role. A relative preponderance of cases due to Enterobacteriaceae was noted within the first week after catheter implantation. In contrast with this, peritonitis with skin microorganisms was not associated with the implantation of catheters.

Adolescent↗
PubMed1984

Angioendotheliosarcoma of the nose--a case report.

Angioendotheliosarcoma of the face or scalp is regarded as a highly malignant tumor. We present a case with onset as a purple macule on the nose, suspected to be rosacea, and emphasize the use of early skin biopsy when a red or purple discoloration is seen in the face of elderly people.

Aged↗
PubMed1984

Recall of UVB-induced erythema in breast cancer patient receiving multiple drug chemotherapy.

One day after sunbathing, a breast cancer patient received intravenous methotrexate, cyclophosphamide and 5-fluorouracil and had a recall of her UV erythema over the following week. Phototesting with UVA and UVB prior to and after a subsequent chemotherapy treatment showed a UVB-induced recall of erythema, as well as a phototoxicity-like response. Skin biopsies from test sites were compatible with phototoxic dermatitis. The occurrence of both erythema recall and the phototoxicity-like reaction suggests that more than one mechanism is involved in this side effect.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1984

Phototoxicity and antipsoriatic effect of a topical methoxypsoralen solution in relation to the application time.

The phototoxicity and antipsoriatic activity of a topically applied 0.075% methoxypsoralen alcohol-glycerol solution was investigated in relation to the interval between drug application and irradiation. On healthy skin, maximum UVA sensitivity for erythema development appeared 40 to 60 min after the application of the methoxypsoralen solution, but in psoriatic plaques the antipsoriatic UVA sensitization reached its maximum after 10 to 20 min. This difference between induction of antipsoriatic effect and erythema sensitivity may be explained by rapid penetration of methoxypsoralen in psoriatic lesions or by different targets at the cellular level for the erythema-producing effect and the antipsoriatic effect.

Administration, Topical↗
PubMed1984

Thalidomide neurotoxicity.

Of six patients treated with thalidomide for either prurigo nodularis or discoid lupus erythematosus, four had paresthesias in the hands and feet and one also complained of muscular pain and stiffness. Clinical neurological findings in all four patients were normal. Subsequent electrophysiological examination disclosed a peripheral neuropathy in five of the six patients; two had electrophysiological signs of a polyneuropathy and three of a carpal tunnel syndrome. Symptoms and abnormal electrophysiological findings were still present in one patient one year after the discontinuation of thalidomide therapy. Since reports on thalidomide neurotoxicity have shown that the neurological symptoms are long standing and possibly irreversible, it is obviously important to inform patients of this possible side effect and to evaluate them closely for the symptoms and electrophysiological signs of evolving neurological changes.

Adult↗
PubMed1983

Nickel in tap water.

Nickel analyses of tap water from several sources in Copenhagen gave up to 490 X 10(-6) g X 1(-1) in the first 250 ml portions. Hot water gave higher values than cold water. After flushing for 5 min, low values were found. Considerable variation from time to time and from tap to tap was found. Drinking of only the first portion in the morning might have an influence on nickel hand eczema.

Adult↗
PubMed1983

Is Cytox 3522 (10% methylene-bis-thiocyanate) a human skin sensitizer?

Methylene-bis-thiocyanate is an antimicrobial agent in Cytox 3522 (American Cyanamid Corporation) and Nalco 206 (Nalco Chemical Company). Both are wide-spectrum industrial biocides. Cytox 3522 showed a strong sensitization potential in guineau pigs using the Guinea Pig Maximization Test and the Open Epicutaneous Test procedures. In spite of this, human sensitization has not been reported. This may be explained by several factors such as limited exposure, low-use concentration and a lack of diagnostic patch tests in selected patients.

Animals↗
PubMed1983

Allergic contact dermatitis from 2-n-octyl-4-isothiazolin-3-one, a paint mildewcide.

Severe allergic contact dermatitis from a paint mildewcide, 2-n-octyl-4-isothiazolin-3-one, developed in a worker formulating latex paints within a paint manufacturing company, Guinea pig maximization testing demonstrated this to be a moderate sensitizer. Further cases of allergic contact dermatitis may be encountered as the use of this biocide increases in the market place.

Adult↗
PubMed1983

Decubitus prophylaxis: a prospective trial on the efficiency of alternating-pressure air-mattresses and water-mattresses.

Six hundred patients at risk for pressure sores were randomized in either a control group or one of two experimental groups placed on alternating-pressure air-mattresses and water-mattresses. The groups remained comparable throughout the 10-day study period. Twenty-one patients from the control group developed decubitus ulcers, compared with 7 in each of the other groups. Patient and ward personnel opinions on the acceptability of the three types of mattresses were registered.

Adolescent↗
PubMed1982

Prevention of pressure sores by identifying patients at risk.

The risk of pressure sores developing in patients admitted with acute conditions was assessed by a simple risk score system based on age, reduced mobility, incontinence, pronounced emaciation, redness over bony prominences, unconsciousness, dehydration, and paralysis in a prospective clinical study. During seven months in 1977, 600 of 3571 patients were classified as at risk. Of these 35 (5.8%) developed sores compared with five (0.2%) of those not at risk. The results of this study compared with those over the same period in 1976 show that close observation of at-risk patients and early detection of pressure sores prevents their development.

Age Factors↗