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K Donath

Publications and source records attributed to K Donath.

At least 163 records · Page 9Linked to original sources
PubMed1980

Histologic subclassification of the cystadenolymphoma of the parotid gland. Analysis of 275 cases.

Cystadenolymphomas (CAL) of the parotid gland are variable in their epithelial differentiation and the ratio of the epithelial tumor component to lymphoid stroma. Two hundred and seventy five cases of CAL from the files of the Salivary Glands Register of the Institute of Pathology, University of Hamburg (1965-1979) were analysed. Their pathogenesis from parenchyma included in regional lymph nodes is discussed. The following subclassification was established. 1. Depending on to the ratio of epithelial tumor component to lymphoid stroma, three subtypes were distinguished. Subtype 1, "typical CAL" with an epithelial tumor component of 50%, amounted to 77% of all cases of CAL studied. Oncocytic differentiation and focal metaplasia to goblet cells or squamous epithelium was also found. 13.5% of CAL were classified as subtype 2, "stroma-poor CAL" with an epithelial tumor component of 70 to 80%. The tumor structure was similar to that of an oncocytoma in places. Two per cent of the CAL were in subtype 3, "stroma-rich CAL" with an epithelial tumor component of only 20 to 30%. Subtype 3 was found solely in men. The average age at presentation (61 years) was slightly lower than that of all the cases studied (65 years). 2. In 7.5% of the cases large areas of squamous cell metaplasia and regressive changes was found within a CAL. These cases were classified as subtype 4 ("metaplastic CAL"). The average age was 67 years. The case histories showed that 20% of these metaplastic CAL had previously been irradiated. 3. Bilateral CAL was found in 7.5% of the cases. In 4% multifocal CAL occurred in the parotid gland unilaterally. Recurrences were observed in 2% of all CAL. 4. Carcinoma in CAL is rare (we found two cases in our own material). In 50% of all cases reported radiotherapy was mentioned in the case histories. 5. Malignant tumors coincident with CAL were recorded in 3% of the cases. 6. The lymphoid stroma showed reaction patterns similar to those of the regional lymph nodes. These included granulomatous changes (foreign body granuloma with cholesterol deposits, tuberculosis) and tumor metastases. In the neighborhood of oncocytic tumor epithelium focal accumulations plasma cells forming IgA and IgG were found. Metaplasia to squamous epithelium is believed to be caused by circulatory disturbances, irradiation, and other noxae. In the differential diagnosis of the stroma-poor subtype 2, oncocytoma and cystic sialadenoma must be excluded, and in the differential diagnosis of subtype 4 (the metaplastic CAL), sebaceous adenoma, mucepidermoid tumor, squamous cell carcinoma, lymphoepithelioma, and other non-tumorous lesions of the parotid gland (lymphoepithelial cysts, myoepithelial parotitis) must be ruled out. Our findings suggest that CAL develops from parenchyma included in parotid lymph nodes with the oncocytic ductal epithelium representing the neoplastic component.

Adenolymphoma↗
PubMed1980

[Salivary gland infarction (necrotizing sialometaplasia) caused by intraglandular circulation disorders in the rat parotid gland. Experimental study].

The morphologic alterations with necrotising sialometaphasia are very characteristic microscopically. The false diagnosis of a squamous cell carcinoma or a mucoepidermoid tumor is possible if the examiner is not familiar with the signs of necrotising sialometaplasia. Vascular insufficiency with a zone of relative and absolute ischemia has been discussed as the etioloic factor (Donath 1979). In experimental studies of the parotid glands of rats following intraglandular ligature of a vessel, a position was taken regarding the pathohistology described as the pathogenesis of necrotising sialometaplasia (salivary gland infarct).

Animals↗
PubMed1979

[Contribution to the etiology and pathogenesis of chronic recurring parotitis].

Chronic, recurrent parotitis was classified as a disease of the salivary glands of bacterial and inflammatory origin. Forty biopsy specimens of the parotoid gland taken from patients with chronic, recurrent parotitis were examined via light and electron microscopy; virus or bacteria could not be identified. The pathomorphologic findings with chronic, recurrent parotitis correspond basically with those of an experimental ligature of the ganglia. The pathogenesis was discussed. The results of the investigation indicated that, in terms of the pathogenesis, chronic, recurrent parotitis represents a special form of electrolytic and/or obstructive sialadenitis.

Chronic Disease↗
PubMed1979

[Swellings of the cheek from sialosis (author's transl)].

The term sialosis was introduced by Rauch (1956) and was associated with a symmetrical, painless, recurrent enlargement of the salivary glands. Included among the sialoses were non-inflammatory and inflammatory diseases of the salivary glands. A more recent definition still in use today was made by Seifert (1960) and includes disturbances in metabolism and secretion of the parotid gland. The term sialosis was also recommended by the World Health Organization (Thackray and Sobin, 1972) to replace the descriptive term "asymptomatic salivary enlargement." In addition to inflammatory diseases and tumors of the salivary glands, sialosis is the most common disease of salivary tissue recorded at the Institute for Pathology, University of Hamburg. In 50% of patients with sialosis, a syntropic occurrence of other diseases can be found which can be further classified as endocrine, dystrophic-metabolic, and neurogenic sialoses. All clinical types of sialosis are represented by only one morphological pattern: enlarged acinar cells with either a granular pattern, a numerical increase in secretory granules or a vacuolar transformation of the cytoplasm; degenerative changes are seen in myoepithelial cells and the autonomic nervous system. Three types of sialosis can be further distinguished by the electron density of the acinar granules. These are granular, vesicular or mixed. However, there is no correlation between the clinical and morphological forms of sialosis. Experimental destruction of the sympathetic nervous system results in tissue changes which are similar to sialosis. These ultrastructural alterations are interpreted as a disturbance of secretion, and suggest that degeneration of the autonomic nervous system is the common pathogenic principle in all types of sialosis.

Animals↗
PubMed1979

[Pathohistology of necrotizing sialometaplasia in parotid glands (author's transl)].

Under the descriptive term necrotizing sialometaplasia a lesion (infarct) is described in the minor salivary glands of the mouth, mucous glands in the nose and in the maxillary sinus. Identical changes are seen in the parotid gland after surgical treatment. In the German literature there is no report on necrotizing sialometaplasia or infarction of salivary gland. In this paper 6 infarcts of the parotid gland are reported. The pathohistologic picture is described, the proposed etiopathogenic factors are discussed. The diagnostic problems between the infarct of salivary glands and squamous carcinoma and low grade mucoepidermoid tumours were pointed out.

Adult↗
PubMed1978

[Pathohistological findings in infarcted parotid glands (necrotizing sialometaplasia) (author's transl)].

In 1973 Abrams et al. described a nonneoplastic lesion named "necrotizing sialometaplasia". Since this date additional cases have been reported. The lesion might be misdiagnosed either mucoid tumor or squamous carcinoma. The cases reported in the following years were localised on the hard palate, lower lip, nose and in the major salivary glands. By the "Speicheldrüsenregister" of the Institute of Pathology of the University of Hamburg five cases of infarcted parotid glands were registered during the years of 1965--1977. All infarcts are observed in patients with tumors in the parotid region. No infarct happened spontaneously. Histologically two forms of infarcts are distinguished: haemorrhagic and ischaemic. In both forms of infarcts there necrosis of acini and squamous metaplasia in intercalar and striated ducts. Degenerative changes are seen in the center of ducts with squamous metaplasia. The reaction of the interstices of the two forms of infarction are different: In the ischaemic there lipomatosis, and in the haemorrhagic there are fibrosis. Our findings are exactly as described for minor salivary glands in necrotizing sialometaplasia.

Humans↗
PubMed1978

[On the occurrence of so-called clear cells in salivary gland tumors. Ultrastructure and differential diagnosis (author's transl)].

Clear cell tumors of the salivary glands are monomorphic clear cell adenomas, clear cell carcinomas, clear cell variants of acinic cell and mucoepidermoid tumours, sebaceous cell tumors, salivary duct carcinomas and pleomorphic adenomas with clear cell sectors. At the light microscopical level the descriptive term of the clear cell comprises cell types of different origin and functional importance which can be differentiated by cytochemistry and electron microscopy. The following cell types were analysed precisely: indifferent duct cells (small formation of organelles, desmosomes), storing striated duct cells (glycogen granules, multiple mitochondrias, basal labyrinth), myoepithelial cells (myofilaments, pinocytosis vesicles, lipofuscin granules, hemidesmosomes), goblet cells (mucous vacuoles, basal endoplasmatic reticulum), sebaceous cells (lipid droplets, microvilli, desmosomes) and clear acinic cells (electron pale secretory granules, small mitochondrias, small golgi apparatus). Clear cell tumor types of the salivary gland region which primarely do not derive from the salivary gland tissue must also be included in the differential diagnoses. These are metastases of hypernephroid renal carcinomas, paragangliomas, glomus tumors of Masson, granular cell tumor and alveolar soft-part sarcomas.

Adenoma↗
PubMed1977

[Carcinomas in papillary cystadenolymphomas of the parotid gland--definition and differential diagnosis (author's transl)].

Within a collective of 1431 salivavry gland tumors of the salivary gland register (1965--1976) an observation has been done, which has been classified as a "carcinoma in a papillary cystadenolymphoma". Corresponding to the "carcinoma in a pleomorphous adenoma" of the WHO-classification of salivary gland tumors the terminus "carcinoma in a cystadenolymphoma" is further defined. 6 additional cases from the literature are reviewed. The possible role of epithelial metaplasia and of a proceding radiation in the development of carcinomas in cystadenolymphomas are discussed. The following other tumors have to be differentiated from a carcinoma in a cystadenolymphoma: Metastases of other tumors beyond a cystadenolymphoma; malignant lymphoepithelial lesions (predominantly malignant lymphomas in a preexisting immune-sialadenitis of the myoepithelial sialadenitis type; rare carcinomas), and lymphoepitheliomas.

Adenocarcinoma↗
PubMed1977

[Granular cell tumour of the parotid gland. The differential diagnostic criteria (author's transl)].

Granular cell tumours (synonyms: myoblastmyomas, granular neuromas, granular cell myoblastomas) are localized predominantly in the head and neck area, especially in the region of tongue and larynx. Only 2 observations of an occurrence in the parotid gland exist till now in the world literature. This paper reports a further case of an occurrence in the parotid gland in a 6-years-old girl. The about cherrygreat tumour was distinctly limited and showed histologically a typic lobular arrangement of acidophilic granular cells. No recidive was observed in the prevailing postoperative phase of 3 years. The differential diagnosis of the granular cell tumorus is demonstrated to other tumour types with similar histological arrangement, expecially to the alveolar soft-part sarcoma, the acinic cell tumour and the non-chrom-affine paraganglioma (chemodectoma).

Adult↗
PubMed1977

[On the pathogenesis of the Küttner tumor of the submandibular gland -- Analysis of 349 cases with chronic sialadenitis of the submandibular (author's transl)].

In view of the etiology and pathogenesis of the so-called Kütter tumor (chronic sialadenitis of the submandibular gland) gland resections of 349 patients (salivary gland register at the Institute of Pathology, University of Hamburg; period 165--1974) were analyzed pathohistologically. In 143 cases (41%) a sialolithiasis of the submandibular gland occurred simultaneously. Regarding the degree of the inflammation 4 stages were distinguished (stage 1 = focal sialadenitis; stage 2= diffuse lymphocytic sialadenitis with salivary gland fibrosis; stage 3 = chronic sclerosing sialadenitis with salivary gland sclerosis; stage 4= chronic progressive sialadenitis with salivary gland cirrhosis). Twenty-five per cent of the cases were classified in stage 1, 19% in stage 2, 38% in stage 3, and 18% in stage 4. A predominance of the male sex (70%) was observed especially in stage 4. The initial stage is characterized by a periductally lymphocytic infiltration, ectasias of the ducts, and alteration of the secret in the duct lumens (spheroliths, microliths). In stages 2--3 an increase of the inflammatory infiltration with lymph follicles, considerable alterations of the ducts (metaplasias, dysplasias, regenerates of the ducts), and a parenchymal reduction were found. This process is combined with an increase of the interstitial connective tissue and a cicatrication of the salivary gland parenchyma. In the final stage, 4, a cirrhotic gland transformation with progressive loss of the parenchyma and considerable duct destruction appeared. From the pathogenetic course of the inflammation and the comparison with other forms of sialadenitis, the conclusion is drawn that two etiologic factors are important in the Küttner tumor: an initial disturbance of secretion with an obstructive electrolyte sialadenitis and an immune reaction of the salivary duct system with the final phase of an obstructive, progressive immunosialadenitis.

Adolescent↗